Results 141 to 150 of about 2,481,819 (312)

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

The genome sequence of Veronica verna L., 1753 (Lamiales: Plantaginaceae) [version 1; peer review: 2 approved]

Wellcome Open Research
We present a genome assembly of Veronica verna (Spring Speedwell; Streptophyta; Magnoliopsida; Lamiales; Plantaginaceae). The genome sequence has a total length of 463.88 megabases.
Maarten J. M. Christenhusz, Sahr Mian, Ilia J. Leitch, Andrew G. Shaw   +3 more
doaj   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Assembling genomes with complex genomic repeats

, 2017
Nippostrongylus brasiliensis is a rodent parasite with lifecycle and morphology similar to the human hookworm. The current draft genome, created by the Wellcome Trust Sanger Institute using Illumina reads, is highly fragmented with substantial duplication, but appears to be reasonably complete at the gene level.
Eccles, David, Chandler, Jodie, Camberis, Mali, Gros, Graham Le, Ewbank, Jonathan   +4 more
openaire   +1 more source

A chromosome-level genome assembly of Guimi No. 2 (Actinidia chinensis)

Scientific Data
In this study, we report a high-quality chromosome-level genome assembly of Actinidia chinensis var. chinensis ‘Guimi No. 2’. This cultivar, discovered in Guizhou karst ecosystems, exhibits resistance to Pseudomonas syringae pv. actinidiae (Psa). Using a
Jia Zhou, Feifei Wang, Weiming Zhong, Qianming Zheng, Yong Qi, Binbin Shi, Qing Liu, Sheng Zhang, Nan Wang, Dongmei Tang   +9 more
doaj   +1 more source

The genome sequence of Plagiothecium denticulatum (Hedw.) Schimp. (Hypnales: Plagiotheciaceae) [version 1; peer review: 2 approved]

Wellcome Open Research
We present a genome assembly of Plagiothecium denticulatum (dented silk-moss; Streptophyta; Bryopsida; Hypnales; Plagiotheciaceae). The genome sequence has a total length of 405.78 megabases.
David Bell, David G. Long
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Tetraploid Wheat Germplasm Diversity Scan based on the Durum Wheat Genome Assembly

, 2018
The genome of modern durum wheat (DW) cultivar Svevo has been assembled based on a combination of whole genome shotgun sequencing (270X), NRGene deNovoMagic assembler, high-resolution genetic mapping obtained from the cross between Svevo DW and Zavitan ...
Raj K Pasam, Silvio Salvi, Hakan Ozkan, Matt Hayden, Simona Corneti, Elisabetta Mazzucotelli, Steven Xu, Curtis Pozniak, The International Durum Wheat Genome Sequencing Consortium, Roberto Tuberosa, Benjamin Kilian, Shiaoman Chao, Elisabetta Frascaroli, Marco Maccaferri, Anna Maria Mastrangelo, Nicola Pecchioni, Luigi Cattivelli, Neils Harris, Reem Joukhadar   +18 more
core   +1 more source

The genome sequence of the common alder, Alnus glutinosa (L.) Gaertn. (Betulaceae) [version 1; peer review: 2 approved]

Wellcome Open Research
We present a genome assembly of a diploid specimen of Alnus glutinosa (the common alder; Streptophyta; Magnoliopsida; Fagales; Betulaceae). The genome sequence has a total length of 456.80 megabases. Most of the assembly is scaffolded into 14 chromosomal
Claudia A. Martin, David G. Bell, Maarten J. M. Christenhusz, Zoë Goodwin   +3 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source