Results 131 to 140 of about 4,666,723 (353)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

GAM: Genomic Assemblies Merger

EMBnet.journal, 2012
Motivations. In the last 3 years more than 20 assemblers have been proposed to tackle the hard task of assembling. Recent evaluation efforts (Assemblathon 1 and GAGE) demonstrated that none of these tools clearly outperforms the others. However, results clearly show that some assemblers performs better than others on specific regions and statistics ...
A Policriti, S Scalabrin, F Vezzi, R Vicedomini   +3 more
openaire   +3 more sources

The genome sequence of the Star Sedge, Carex echinata Murray (Poales: Cyperaceae) [version 1; peer review: 2 approved]

Wellcome Open Research
We present a genome assembly of Carex echinata (Star Sedge; Streptophyta; Magnoliopsida; Poales; Cyperaceae). The assembly consists of two haplotypes with total lengths of 378.73 megabases and 369.81 megabases.
José Ignacio Márquez-Corro, Andrew Griffiths   +1 more
doaj   +1 more source

A chromosome-level genome assembly of garlic (Allium sativum L.) provides insights into genome evolution and allicin biosynthesis.

Molecular Plant, 2020
Garlic, an economically important vegetable, spice, and medicinal crop, produces highly enlarged bulbs and unique organosulfur compounds. Here, we report a chromosome-level genome assembly for garlic, with a total size of approximately 16.24 gigabases ...
Xiu-Dong Sun, Si-Yuan Zhu, Ning-Yang Li, Yi Cheng, Jing Zhao, Xu-Guang Qiao, Li Lu, Shi-Qi Liu, Yan-Zhou Wang, Chan Liu, Benping Li, Wu-Nian Guo, S. Gao, Ze-Mao Yang, Fu Li, Zheng Zeng, Q. Tang, Yupeng Pan, Mengjiao Guan, Jian Zhao, Xiao-Ming Lu, Huan-Wen Meng, Zhenlin Han, Chun-Sheng Gao, Wenkai Jiang, Xing Zhao, Shilin Tian, Jian-Guang Su, Zhi-Hui Cheng, Tou-Min Liu   +29 more
semanticscholar   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Genome Assembly

, 2019
Genome Assembly ...
Namjin Koo (6552410)
core   +1 more source

The genome sequence of Aegilops tauschii subsp. tauschii Coss. accession Ent-118 (Poales: Poaceae) [version 1; peer review: 2 approved, 1 approved with reservations]

Wellcome Open Research
We present a genome assembly of Aegilops tauschii subsp. tauschii accession ‘Ent-118’ (diploid, 2n = 2x = 14, DD; Tausch’s goat grass; Streptophyta; Magnoliopsida; Poales; Poaceae).
Philip M. Howell, Richard Horsnell, Tally I. C. Wright, Bethany Love, James Cockram   +4 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Assembly of Buddleja globosa genome

, 2018
Assembly of Buddleja globosa genome (voucher: R.G. Olmstead 2010-46 [WTU]) from whole-genome shotgun Illumina sequencing.
Chau, John H., Olmstead, Richard G., Richard G. Olmstead (3367334), John H. Chau (5054714)   +3 more
core   +1 more source

Repeat masked genome assembly

, 2023
Repeat-masked genome ...
Feng Zhang (5920121)
core   +1 more source