Results 111 to 120 of about 4,666,723 (353)

A chromosome-level genome assembly of the Korean crossbred pig Nanchukmacdon (Sus scrofa)

Scientific Data, 2023
As plentiful high-quality genome assemblies have been accumulated, reference-guided genome assembly can be a good approach to reconstruct a high-quality assembly.
Daehong Kwon, Nayoung Park, Suyeon Wy, Daehwan Lee, Han-Ha Chai, In-Cheol Cho, Jongin Lee, Kisang Kwon, Heesun Kim, Youngbeen Moon, Juyeon Kim, Woncheoul Park, Jaebum Kim   +12 more
doaj   +1 more source

GCI: a continuity inspector for complete genome assembly

bioRxiv
Motivation Recent advances in long-read sequencing technologies have significantly facilitated the production of high-quality genome assembly. The telomere-to-telomere (T2T) gapless assembly has become the new golden standard of genome assembly efforts ...
Quan-Yu Chen, Chen-Tao Yang, Guo-Jie Zhang, Dong-Ya Wu   +3 more
semanticscholar   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

The chromosomal genome sequence of the sponge Cliona cf. orientalis Thiele (1900) and its associated microbial metagenome sequences [version 1; peer review: 1 approved, 2 approved with reservations, 1 not approved]

Wellcome Open Research
We present a genome assembly from a specimen of Cliona cf. orientalis (Porifera; Demospongiae; Clionaida; Clionaidae). The genome sequence has a total length of 217.17 megabases.
Emma Marangon, Eerik Aunin, Heidi M. Luter, Blake D. Ramsby, Patrick Laffy, Victoria McKenna, Sara C. Bell, Torsten Thomas, Nicole S. Webster, Ute Hentschel, Cara Fiore, Elizabeth Sinclair, Graeme Oatley, Camilla Santos, Noah Gettle, Haoyu Niu, Michael Paulini, Rebecca O’Brien   +17 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

A chromosome-level genome assembly of the Korean minipig (Sus scrofa)

Scientific Data
Recent advancements in sequencing and genome assembly technologies have led to rapid generation of high-quality genome assemblies for various species and breeds.
Suyeon Wy, Daehong Kwon, Woncheoul Park, Han-Ha Chai, In-Cheol Cho, Jaebum Kim   +5 more
doaj   +1 more source

The genome sequence of the Common Brassy Ringlet, Erebia cassioides (Reiner & Hohenwarth, 1792) (Lepidoptera, Nymphalidae) [PDF]

Research Ideas and Outcomes
We present a chromosome-level genome assembly from a female specimen of the Common Brassy Ringlet Erebia cassioides (Arthropoda, Insecta, Lepidoptera, Nymphalidae).
Camille Cornet, Kay Lucek
doaj   +3 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Genome assembly summary statistics.

, 2022
Genome assembly summary statistics.
Matthew Berriman (5353), Aidan Emery (4181572), Nicolas D. Diouf (13215439), James A. Cotton (7410761), Joanne P. Webster (7410752), Geetha Sankaranarayanan (6204827), Duncan J. Berger (13215436), Fiona Allan (473265), Elsa Léger (739966), Muriel Rabone (473264), Mariama Sène (12277832)   +10 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source