Results 111 to 120 of about 2,481,819 (312)

An improved genome assembly of the fluke Schistosoma japonicum.

PLoS Neglected Tropical Diseases, 2019
BackgroundSchistosoma japonicum is a parasitic flatworm that causes human schistosomiasis, which is a significant cause of morbidity in China and the Philippines. A single draft genome was available for S.
Fang Luo, Mingbo Yin, Xiaojin Mo, Chengsong Sun, Qunfeng Wu, Bingkuan Zhu, Manyu Xiang, Jipeng Wang, Yi Wang, Jian Li, Ting Zhang, Bin Xu, Huajun Zheng, Zheng Feng, Wei Hu   +14 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The chromosome-level genome sequences of the freshwater sponge, Spongilla lacustris (Linnaeus, 1759) and the chlorophyte cobiont Choricystis sp., and the associated microbial metagenome sequences [version 1; peer review: 2 approved]

Wellcome Open Research
We present a genome assembly from an individual Spongilla lacustris (freshwater sponge; Porifera; Demospongiae; Spongillida; Spongillidae). The genome sequence is 248.7 megabases in span.
Eerik Aunin, Victoria McKenna, Elizabeth Sinclair, Graeme Oatley, Sally P. Leys, Ute Hentschel, Camilla Santos, Noah Gettle, Haoyu Niu, Michael Paulini, Dirk Erpenbeck   +10 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Insights into teleost sex determination from the Seriola dorsalis genome assembly [PDF]

, 2018
Background The assembly and annotation of a genome is a valuable resource for a species, with applications ranging from conservation genomics to gene discovery.
John R. Hyde, Arun S. Seetharam, Sofia Ortega-García, Snodgrass, Owyn, Owyn Snodgrass, Purcell, Catherine M, Hyde, John R, Andrew J. Severin, Ortega-García, Sofia, Purcell, Catherine, Severin, Andrew, Hyde, John, Seetharam, Arun, Seetharam, Arun S, Severin, Andrew J, Catherine M. Purcell   +15 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Repetitive DNA is associated with centromeric domains in Trypanosoma brucei but not Trypanosoma cruzi. [PDF]

, 2007
BACKGROUND: Trypanosomes are parasitic protozoa that diverged early from the main eukaryotic lineage. Their genomes display several unusual characteristics and, despite completion of the trypanosome genome projects, the location of centromeric DNA has ...
Bot, Christopher, Nilsson, D,, Nilsson, Daniel, Andersson, B,, Andersson, Bjorn, Bot, C,, Obado, SO, Obado, Samson O, Kelly, JM, Kelly, John M   +9 more
core   +1 more source

The genome sequence of the sweet violet, Viola odorata L. (Malpighiales: Violaceae) [version 1; peer review: 2 approved]

Wellcome Open Research
We present a genome assembly of Viola odorata (Sweet violet; Streptophyta; Magnoliopsida; Malpighiales; Violaceae). The genome sequence has a total length of 698.62 megabases. Most of the assembly (99.9%) is scaffolded into 10 chromosomal pseudomolecules.
Maarten J. M. Christenhusz, Ilia J. Leitch, Michael F. Fay   +2 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Addition of the microchromosome GGA25 to the chicken genome sequence assembly through radiation hybrid and genetic mapping [PDF]

, 2008
BACKGROUND: The publication of the first draft chicken sequence assembly became available in 2004 and was updated in 2006. However, this does not constitute a definitive and complete sequence of the chicken genome, since the microchromosomes are ...
Gourichon, David, Dawson, D.A., Deborah A. Dawson (7630160), Gourichon David, Burke, T., F. Vignoles (7630163), Pitel, F., Burke, Terry, Douaud, Marine,, Dawson Deborah A, Olivier Hanotte (89422), Vignoles, Florence, F., Hanotte, Olivier, M. Douaud (7630142), Gourichon, D., Vignoles, F., Morisson, Mireille, Morrison, M., F. Pitel (7630175), Fillon, Valérie, Vignoles Florence, Fillon, V., D. Gourichon (7630157), Gerus, M., M. Tixier-Boichard (7630169), Dawson, D., Bardes, Suzanne, Vignal Alain, Vignoles, Florence,, Fève Katia, Hanotte, O., Vignoles, Florence, S. Bardes (7630154), Bardes Suzanne, Douaud, M., Gerus Marie, Tixier-Boichard, M., K. Fève (7630145), Terry Burke (80052), Vignal, Alain, Bardes, S., Fève, Katia, Pitel, Frédérique, Dawson, Deborah A., Hanotte, Olivier H., Feve, Katia, K., V. Fillon (7630151), Morisson, M., Douaud, Marine, Morisson Mireille, Tixier-Boichard Michèle, Fillon Valérie, M. Gerus (7630148), Douaud Marine, Tixier-Boichard, Michèle, Douaud, Marine, M., Hanotte Olivier, A. Vignal (7630172), M. Morisson (7630166), Dawson, Deborah A, Pitel Frédérique, Gerus, Marie, Feve, Katia,, Vignal, A., Burke Terry, Fève, K.   +65 more
core   +2 more sources