Results 101 to 110 of about 757,981 (296)

First telomere-to-telomere gapless assembly of the rice blast fungus Pyricularia oryzae

Scientific Data
Rice blast caused by Pyricularia oryzae (syn., Magnaporthe oryzae) was one of the most destructive diseases of rice throughout the world. Genome assembly was fundamental to genetic variation identification and critically impacted the understanding of its
Zhigang Li, Jun Yang, Xiaobei Ji, Jintao Liu, Changfa Yin, Vijai Bhadauria, Wensheng Zhao, You-Liang Peng   +7 more
doaj   +1 more source

The chromosome-level genome sequences of the freshwater sponge, Spongilla lacustris (Linnaeus, 1759) and the chlorophyte cobiont Choricystis sp., and the associated microbial metagenome sequences [version 1; peer review: 2 approved]

Wellcome Open Research
We present a genome assembly from an individual Spongilla lacustris (freshwater sponge; Porifera; Demospongiae; Spongillida; Spongillidae). The genome sequence is 248.7 megabases in span.
Eerik Aunin, Victoria McKenna, Elizabeth Sinclair, Graeme Oatley, Sally P. Leys, Ute Hentschel, Camilla Santos, Noah Gettle, Haoyu Niu, Michael Paulini, Dirk Erpenbeck   +10 more
doaj   +1 more source

Improving ancient DNA genome assembly

PeerJ, 2016
Most reconstruction methods for genomes of ancient origin that are used today require a closely related reference. In order to identify genomic rearrangements or the deletion of whole genes, de novo assembly has to be used. However, because of inherent problems with ancient DNA, its
Seitz, Alexander, Nieselt, Kay
openaire   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A Target Restricted Assembly Method (TRAM) for Phylogenomics [PDF]

, 2010
While next generation sequencing technology can produce sequences covering the entire genome, assembly and annotation are still prohibitive steps for many phylogenomics applications.
Hugh M. Robertson, Kevin P. Johnson, Kimberly K. O. Walden   +2 more
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Genomic insights into the endangered white-eared night heron (Gorsachius magnificus)

BMC Genomic Data
Objectives A genome sequence of a threatened species can provide valuable genetic information that is important for improving the conservation strategies.
Haoran Luo, Qingxian Lin, Wenzhen Fang, Xiaolin Chen, Xiaoping Zhou   +4 more
doaj   +1 more source

An improved genome assembly of the fluke Schistosoma japonicum.

PLoS Neglected Tropical Diseases, 2019
BackgroundSchistosoma japonicum is a parasitic flatworm that causes human schistosomiasis, which is a significant cause of morbidity in China and the Philippines. A single draft genome was available for S.
Fang Luo, Mingbo Yin, Xiaojin Mo, Chengsong Sun, Qunfeng Wu, Bingkuan Zhu, Manyu Xiang, Jipeng Wang, Yi Wang, Jian Li, Ting Zhang, Bin Xu, Huajun Zheng, Zheng Feng, Wei Hu   +14 more
doaj   +1 more source