Results 121 to 130 of about 757,981 (296)

The genome sequence of common box, Buxus sempervirens L. (Buxaceae) [version 2; peer review: 2 approved]

Wellcome Open Research
We present a genome assembly from an individual Buxus sempervirens (common box; Streptophyta; Magnoliopsida; Buxales; Buxaceae). The genome sequence has a total length of 676.70 megabases.
Maarten J. M. Christenhusz, Michael F. Fay   +1 more
doaj   +1 more source

Common Signatures of Altered Gene Regulation and Invasiveness of Different Breast Cancer Cell Lines after Matrix Interface Crossing

Advanced Healthcare Materials, EarlyView.
Interface transmigration reprograms triple‐negative breast cancer cells, triggering a shared switch toward more aggressive and invasive phenotypes. Using a collagen I interface model, this study identifies shared transcriptional changes involving proliferation, chromatin remodeling, and DNA repair pathways.
Cornelia Clemens, Hannah Trampert, Nataliia Kotsiuba, Tilo Pompe   +3 more
wiley   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

A chromosome-level genome assembly of Guimi No. 2 (Actinidia chinensis)

Scientific Data
In this study, we report a high-quality chromosome-level genome assembly of Actinidia chinensis var. chinensis ‘Guimi No. 2’. This cultivar, discovered in Guizhou karst ecosystems, exhibits resistance to Pseudomonas syringae pv. actinidiae (Psa). Using a
Jia Zhou, Feifei Wang, Weiming Zhong, Qianming Zheng, Yong Qi, Binbin Shi, Qing Liu, Sheng Zhang, Nan Wang, Dongmei Tang   +9 more
doaj   +1 more source

The genome sequence of the Roundleaf geranium, Geranium rotundifolium L. (Geraniales: Geraniaceae) [version 1; peer review: 2 approved]

Wellcome Open Research
We present a genome assembly of Geranium rotundifolium (Roundleaf geranium; Streptophyta; Magnoliopsida; Geraniales; Geraniaceae). The genome sequence has a total length of 497.00 megabases. Most of the assembly (97.57%) is scaffolded into 13 chromosomal
Maarten J. M. Christenhusz, Alex D. Twyford   +1 more
doaj   +1 more source

Genome Assembly Algorithms

Currently, research has entered the genomic era. The high-throughput sequencing of short reads and long reads has increased, while the cost has decreased. Most of the key genomes have been sequenced, and an increasing number of reference genomes from uncommon species are currently in progress toward completion.
Jianbo Jian, Qiang Gao, Jun Cheng, Ye Yin   +3 more
openaire   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

The genome sequence of the common alder, Alnus glutinosa (L.) Gaertn. (Betulaceae) [version 1; peer review: 2 approved]

Wellcome Open Research
We present a genome assembly of a diploid specimen of Alnus glutinosa (the common alder; Streptophyta; Magnoliopsida; Fagales; Betulaceae). The genome sequence has a total length of 456.80 megabases. Most of the assembly is scaffolded into 14 chromosomal
Claudia A. Martin, David G. Bell, Maarten J. M. Christenhusz, Zoë Goodwin   +3 more
doaj   +1 more source

Plant‐Produced Viral Nanoparticles Decorated with Nanobodies Against HER2 Improve Retention and Recruitment of Immune Cells in Solid Tumors

Advanced Healthcare Materials, EarlyView.
Potato virus X is a filamentous RNA plant virus that can be engineered into a molecular tool for cancer therapy. We produced genetically‐encoded virus‐derived nanoparticles decorated with nanobodies targeting cancer cell receptors, epidermal growth factor receptor (EGFR) and human epidermal growth factor 2 (HER2).
Enrique Lozano‐Sanchez, Miguel A. Moreno‐Gonzalez, Fernando Merwaiss, Nicole F. Steinmetz, José‐Antonio Daròs   +4 more
wiley   +1 more source

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source