Results 241 to 250 of about 1,963,187 (422)

Mapping the emerging field of genome editing [PDF]

, 2013
Aliya Kuzhabekova, Jennifer Kuzma
openalex   +1 more source

Frequency‐Dependent Demethylation of Cancer DNAs by High‐Power Terahertz Radiation

Advanced Photonics Research, EarlyView.
Effective demethylation of cancer DNA is successfully demonstrated by resonant irradiation with high‐power terahertz (THz) waves at the 10 mW level, combined with metamaterial‐based THz filters. The dependence of spectral filtering on demethylation indicates that the resonant frequency of 1.6 THz of cancer DNAs plays a crucial role in reducing the ...
Chaeyoon Kim, Seung Won Jin, Seong Cheol Lee, Donghak Oh, Soojeong Baek, Bumki Min, Hee‐Jin Yang, Joo‐Hiuk Son, Fabian Rotermund   +8 more
wiley   +1 more source

CRISPR genome editing [PDF]

, 2013
Chris Cain
openalex   +1 more source

Prime genome editing in rice and wheat

Nature Biotechnology, 2020
Qiupeng Lin, Y. Zong, Chenxiao Xue, Shengxing Wang, Shuai Jin, Zixu Zhu, Yanpeng Wang, Andrew V. Anzalone, Aditya Raguram, Jordan L. Doman, David R. Liu, Caixia Gao   +11 more
semanticscholar   +1 more source

Insights into the Dynamics and Binding Mechanisms of the Alkhumra Virus NS2B/NS3 Protease: A Molecular Dynamics Study

Advanced Theory and Simulations, EarlyView.
The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak, Shivananda Kandagalla, Ramesh Sistla   +2 more
wiley   +1 more source

Enhancing specificity of RNA-guided clustered, regularly interspaced short palindromic repeats (CRISPR)-based genome editing with paired guide RNAs [PDF]

, 2013

openalex   +1 more source

Disentangling the Switching Behavior in Functional Connectivity Dynamics in Autism Spectrum Disorder: Insights from Developmental Cohort Analysis and Molecular‐Cellular Associations

Advanced Science, EarlyView.
A region‐wise functional connectivity dynamics (FCD) switching index (RFSI) identifies abnormal drivers in ASD across development, linked to salience/ventral attention, default mode, and frontoparietal networks. RFSI changes correlate with transcriptomic and neurotransmitter profiles, and supported by gene‐edited ASD monkeys.
Wei Li, Xia Qiu, Jin Chen, Kexuan Chen, Meiling Chen, Yinyan Wang, Wenjie Sun, Jing Su, Yongchang Chen, Xiaobao Liu, Congying Chu, Jiaojian Wang   +11 more
wiley   +1 more source

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling [PDF]

, 2014
Randall J. Platt, Sidi Chen, Yang Zhou, Michael J. Yim, Lukasz Swiech, H. Kempton, James E. Dahlman, Oren Parnas, Thomas Eisenhaure, Marko Jovanović, D. B. Graham, Siddharth Jhunjhunwala, Matthias Heidenreich, Ramnik J. Xavier, Robert Langer, Daniel G. Anderson, Nir Hacohen, Aviv Regev, Guoping Feng, Phillip A. Sharp, Feng Zhang   +20 more
openalex   +1 more source

Deciphering the Transcription Factor Landscape in Prostate Cancer Progression: A Novel Approach to Understand NE Transdifferentiation

Advanced Science, EarlyView.
The study deciphers the landscapes of lineage‐related transcription factors in prostatic adenocarcinoma and neuroendocrine prostate cancer using an innovative approach. These findings, validated across cohorts, highlight TFs' roles in cell development and offer novel therapeutic targets.
Yu Wang, Hui Xue, Xiaohui Zhu, Dong Lin, Zheng Chen, Xin Dong, Junru Chen, Mingchen Shi, Yuchao Ni, Jonathan Cao, Rebecca Wu, Connie Kang, Xinyao Pang, Francesco Crea, Yen‐Yi Lin, Colin C. Collins, Martin E. Gleave, Abhijit Parolia, Arul Chinnaiyan, Christopher J. Ong, Yuzhuo Wang   +20 more
wiley   +1 more source

Genome editing of BmFib-H gene provides an empty Bombyx mori silk gland for a highly efficient bioreactor [PDF]

, 2014
Sanyuan Ma, Run Shi, Xiaogang Wang, Yuanyuan Liu, Jiasong Chang, Jie Gao, Wei Lü, Jianduo Zhang, Ping Zhao, Qingyou Xia   +9 more
openalex   +1 more source