Results 241 to 250 of about 571,422 (359)

Genome editing for sustainable agriculture in Peru: advances, potential applications and regulation. [PDF]

Front Genome Ed
Mestanza M, Hernández-Amasifuen AD, Pineda-Lázaro AJ, Eriksson D, Guerrero-Abad JC.   +4 more
europepmc   +1 more source

Bacterial Delivery of TALEN Proteins for Human Genome Editing

, 2014
Jingyue Jia, Yongxin Jin, Ting Bian, Donghai Wu, Lijun Yang, Naohiro Terada, Weihui Wu, Shouguang Jin   +7 more
openalex   +2 more sources

Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing [PDF]

, 2015
Shin‐Heng Chiou, Ian P. Winters, Jing Wang, Santiago Naranjo, Crissy Dudgeon, Fiona B. Tamburini, Jennifer J. Brady, Dian Yang, Barbara M. Grüner, Chen-Hua Chuang, Deborah R. Caswell, Hong Zeng, Pauline Chu, Grace Kim, Darren R. Carpizo, Seung K. Kim, Monte M. Winslow   +16 more
openalex   +1 more source

LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing

Advanced Science, EarlyView.
This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang, Yuehui Xi, Qiaojun Fang, Sai Shi, Fei Wang, Fuyu Xian, Zhongyang Zhang, Yuxin Yang, Xishuo Jin, Xiaomin Wang, Chen Cao, Hailin Zhang, Nikita Gamper, Zhigang Xu, Haitao Shen, Ping Lv   +15 more
wiley   +1 more source

Promoter replacement by genome editing creates gain-of-function traits in Arabidopsis. [PDF]

Plant Biotechnol J
Nobusawa T, Nakano M, Nagashima Y, Kusaba M.   +3 more
europepmc   +1 more source

Engineered Viruses as Genome Editing Devices [PDF]

, 2015
Xiaoyu Chen, Manuel A. F. V. Gonçalves
openalex   +1 more source

Development and Validation of Machine Learning‐Based Marker for Early Detection and Prognosis Stratification of Nonalcoholic Fatty Liver Disease

Advanced Science, EarlyView.
This study constructs a stacked multimodal machine learning model for nonalcoholic fattly liver disease (NAFLD) by integrating genetic and clinical features, and synthesize an in‐silico quantitative marker (ISNLD) that enables personalized risk stratification for intrahepatic and extrahepatic outcomes of high‐risk individuals of NAFLD.
Lushan Xiao, Lin Zeng, Jiaren Wang, Chang Hong, Ziyong Zhang, Chengkai Wu, Hao Cui, Yan Li, Ruining Li, Shengxing Liang, Qijie Deng, Wenyuan Li, Xuejing Zou, Pengcheng Ma, Li Liu   +14 more
wiley   +1 more source

Advances in Therapeutic Applications of CRISPR Genome Editing for Spinal Pain Management. [PDF]

Neurospine
Kang CY, Been KW, Kang MH, Choi MS, Kang RH, Hur JW, Hur JK.   +6 more
europepmc   +1 more source

Faculty Opinions recommendation of Targeted genome editing across species using ZFNs and TALENs.

, 2014
Ronald Ellis
openalex   +1 more source

Branched‐Chain α Keto‐Acid Dehydrogenase Kinase‐Mediated AKT Phosphorylation Promotes RCC Tumorigenesis and Drug Resistance

Advanced Science, EarlyView.
This study identifies a novel oncogenic role and a previously unrecognized phosphorylation substrate of BCKDK in RCC, wherein it promotes tumor progression and drug resistance through AKT phosphorylation at both Thr308 and Ser473 sites and activation of AKT/mTOR and AKT/ABCB1 signaling pathways, offering a promising prognostic marker and therapeutic ...
Qin Tian, Jinxiang Wang, Qiji Li, Yangruiyu Liu, Yanping Chen, Jiacheng Feng, Zi‐Ning Lei, Harsh Patel, Chao‐Yun Cai, Yuzhi Xu, Chuntao Quan, Lingyan Fei, Zexiu Xiao, Shuo Fang, Tianxin Lin, Zhe‐Sheng Chen, Yuchen Liu, Leli Zeng, Yihang Pan   +18 more
wiley   +1 more source