Results 241 to 250 of about 1,632,775 (273)
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2023
The generation of genetically engineered (GE) pigs for disease modeling and xenotransplantation has been massively facilitated by the discovery of the CRISPR/Cas9 system. For livestock, genome editing is a powerful tool when used in combination with either somatic cell nuclear transfer (SCNT) or microinjection (MI) into fertilized oocytes.
David, Preisinger +4 more
openaire +2 more sources
The generation of genetically engineered (GE) pigs for disease modeling and xenotransplantation has been massively facilitated by the discovery of the CRISPR/Cas9 system. For livestock, genome editing is a powerful tool when used in combination with either somatic cell nuclear transfer (SCNT) or microinjection (MI) into fertilized oocytes.
David, Preisinger +4 more
openaire +2 more sources
2019
Programmable nucleases like CRISPR/Cas9 enable to edit the mouse genome directly in the zygote. Several methods have been successfully used for this. Here we describe injection into one of the pronuclei of the zygote and electroporation of zygotes. Alternative methods will be mentioned.
Lisbeth Ahm Hansen +1 more
openaire +2 more sources
Programmable nucleases like CRISPR/Cas9 enable to edit the mouse genome directly in the zygote. Several methods have been successfully used for this. Here we describe injection into one of the pronuclei of the zygote and electroporation of zygotes. Alternative methods will be mentioned.
Lisbeth Ahm Hansen +1 more
openaire +2 more sources
2022
The diabetes types and its complications have varying developmental and metabolic pathways. There is an interplay of nongenetic and genetic components in pathogenesis of diabetes and its complications. There are several established genes such as ABCC8, TCF7L2, SLC2A2, and CAPN10 which are known to influence blood insulin and glucose levels.
openaire +2 more sources
The diabetes types and its complications have varying developmental and metabolic pathways. There is an interplay of nongenetic and genetic components in pathogenesis of diabetes and its complications. There are several established genes such as ABCC8, TCF7L2, SLC2A2, and CAPN10 which are known to influence blood insulin and glucose levels.
openaire +2 more sources
2021
Although barley is of great importance for the brewing and animal feed industries and is regarded as a model for small grain cereals, only a few results on targeted gene modification using CRISPR/Cas endonuclease technology have been published to date.
Martin Becker, Goetz Hensel
openaire +1 more source
Although barley is of great importance for the brewing and animal feed industries and is regarded as a model for small grain cereals, only a few results on targeted gene modification using CRISPR/Cas endonuclease technology have been published to date.
Martin Becker, Goetz Hensel
openaire +1 more source
Genome editing of a rice CDP-DAG synthase confers multipathogen resistance
Nature, 2023Gan Sha +31 more
semanticscholar +1 more source
Structural biology of CRISPR–Cas immunity and genome editing enzymes
Nature Reviews Microbiology, 2022Joy Y. Wang, P. Pausch, J. Doudna
semanticscholar +1 more source
Boosting plant genome editing with a versatile CRISPR-Combo system
Nature Plants, 2022Changtian Pan +8 more
semanticscholar +1 more source
Regulate genome-edited products, not genome editing itself
Nature Biotechnology, 2016Dana Carroll +4 more
openaire +2 more sources
Programmed genome editing by a miniature CRISPR-Cas12f nuclease
Nature Chemical Biology, 2021Zhaowei Wu +10 more
semanticscholar +1 more source