Results 281 to 290 of about 1,963,187 (422)

High-Efficiency Multiplex Genome Editing of Streptomyces Species Using an Engineered CRISPR/Cas System

, 2014
Ryan E. Cobb, Yajie Wang, Huimin Zhao
openalex   +1 more source

Caspase‐6/Gasdermin C‐Mediated Tumor Cell Pyroptosis Promotes Colorectal Cancer Progression Through CXCL2‐Dependent Recruitment of Myeloid‐Derived Suppressor Cells

Advanced Science, EarlyView.
Hypoxic and low‐glucose conditions in tumor tissues trigger colorectal tumor cell pyroptosis via sequential activation of the Caspase‐1/Caspase‐6/GSDMC axis. High mobility group box 1 (HMGB1), released from GSDMC‐mediated pyroptotic tumor cells, upregulates CXCL2 expression in adjacent tumor cells, thereby recruiting myeloid‐derived suppressor cells ...
Hanchao Gao, Yikun Yao, Weilong Li, Zigan Xu, Wenjun Hu, Kewang Luo, Peishan Chen, Wanjing Shang, Shaodong Luan, Guojun Shi, Mengtao Cao, Pengfei Chen   +11 more
wiley   +1 more source

Editorial: Insights in genome editing in animals 2023/2024. [PDF]

Front Genome Ed
Laible G, Cigan M.
europepmc   +1 more source

Immune and Angiogenic Profiling of Mesenchymal Stem Cell Functions in a Subcutaneous Microenvironment for Allogeneic Islet Transplantation

Advanced Science, EarlyView.
With emphasis on a diabetic state, this study highlights the role of mesenchymal stem cells (MSCs) in enhancing vascularization and modulating immune responses within a subcutaneous platform for cell transplantation for type 1 diabetes (T1D). Comprehensive profiling of MSC‐induced angiogenic and immune responses, provides insight into the role of MSCs ...
Jocelyn Nikita Campa‐Carranza, Simone Capuani, Ashley L. Joubert, Nathanael Hernandez, Tommaso Bo, Octavio I. Sauceda‐Villanueva, Marzia Conte, Letizia Franco, Marco Farina, Gabrielle E. Rome, Yitian Xu, Junjun Zheng, Lissenya B. Argueta, Jean A. Niles, Fotis Nikolos, Corrine Ying Xuan Chua, Shu‐Hsia Chen, Joan E. Nichols, Norma S. Kenyon, Alessandro Grattoni   +19 more
wiley   +1 more source

CRISPR-mediated genome editing of wheat for enhancing disease resistance. [PDF]

Front Genome Ed
Waites J, Achary VMM, Syombua ED, Hearne SJ, Bandyopadhyay A.   +4 more
europepmc   +1 more source

Whole-Genome Sequencing Analysis Reveals High Specificity of CRISPR/Cas9 and TALEN-Based Genome Editing in Human iPSCs

, 2014
Cory Smith, Athurva Gore, Wei Yan, Leire Abalde-Atristain, Zhe Li, Chaoxia He, Ying Wáng, Robert A. Brodsky, Kun Zhang, Linzhao Cheng, Zhaohui Ye   +10 more
openalex   +1 more source

CRISPR/CAS9-Mediated Genome Editing of miRNA-155 Inhibits Proinflammatory Cytokine Production by RAW264.7 Cells [PDF]

, 2015
Weixia Jing, Xuewu Zhang, Wenyan Sun, Xiujuan Hou, Zhongqiang Yao, Yuelan Zhu   +5 more
openalex   +1 more source

Coordinated Role of Autophagy and ERAD in Maintaining Neuroendocrine Function by Preventing Prohormone Aggregation

Advanced Science, EarlyView.
By studying the maturation mechanisms of vasopressin (AVP), this manuscript identifies FAM134B‐mediated ER‐phagy as a critical pathway for degrading both aggregated proAVP and the key ERAD component, HRD1. HRD1 induction mitigates proAVP aggregation and support AVP neuron function in the absence of autophagy.
Xuya Pan, Xing He, Su Wu, Na Xiong, Xinyu Hou, Heting Wang, Diane Somlo, Martin Spiess, Haiyang Wang, Jifeng Yang, Chunliang Li, Shasha Li, Wenbin Ma, Yanming Chen, Jun Cui, Ling Qi, Guojun Shi   +16 more
wiley   +1 more source

Call for Evidence held by the Nuffield Council on Bioethics on Genome editing [PDF]

, 2016
O'Neill, H
core  

Intein-mediated split SaCas9 for genome editing in plants. [PDF]

Front Genome Ed
Hu D, Hu L, Lu Y, Dong X, Cao X, Bai S, Zhang L, Li D, Sun Y.   +8 more
europepmc   +1 more source