Results 61 to 70 of about 1,979,376 (400)

Genome edited sheep and cattle [PDF]

open access: yesTransgenic Research, 2014
Genome editing tools enable efficient and accurate genome manipulation. An enhanced ability to modify the genomes of livestock species could be utilized to improve disease resistance, productivity or breeding capability as well as the generation of new biomedical models. To date, with respect to the direct injection of genome editor mRNA into livestock
Proudfoot, Christopher   +10 more
openaire   +4 more sources

Comprehensive assessment of miniature CRISPR-Cas12f nucleases for gene disruption

open access: yesNature Communications, 2022
CRISPR-Cas12f nucleases can be effectively packaged into AAVs for gene therapy, but a systematic evaluation of editing outcomes is lacking. Here the authors perform a comprehensive assessment of 4 Cas12f proteins and compare to Cas9 and two Cas12a ...
Changchang Xin   +6 more
doaj   +1 more source

An NgAgo tool for genome editing: did CRISPR/Cas9 just find a competitor? [PDF]

open access: yes, 2016
While CRISPR/Cas9-mediated genome editing technology has been experiencing a rapid transformation during the past few years, a recent report on NgAgo-mediated single-stranded DNA-guided genome editing may offer an attractive alternative for genome ...
Haydon, Rex C.   +8 more
core   +1 more source

The Role of Recombinant AAV in Precise Genome Editing

open access: yesFrontiers in Genome Editing, 2022
The replication-defective, non-pathogenic, nearly ubiquitous single-stranded adeno-associated viruses (AAVs) have gained importance since their discovery about 50 years ago.
Swati Bijlani   +4 more
semanticscholar   +1 more source

Breakthrough to genome editing [PDF]

open access: yesScience, 2015
A, T, G, C: the alphabet code for the nucleotides that are the building blocks of life. Minor, but consequential, changes in this DNA coding can change gene function. Researchers have long sought better ways to edit the genetic code in cultured cells and laboratory organisms to silence, activate, or change targeted genes to gain a better ...
openaire   +3 more sources

Editing the Mitochondrial Genome

open access: yesNew England Journal of Medicine, 2020
Mending Mitochondrial Mutation For most patients with mitochondrial disorders, most of which are caused by mutations in genes in the mitochondrial genome, only symptomatic treatment is available.
Maria Falkenberg, Michio Hirano
openaire   +3 more sources

Differentially activated B cells develop regulatory phenotype and show varying immunosuppressive features: a comparative study

open access: yesFrontiers in Immunology, 2023
Regulatory B lymphocytes (Bregs) are B cells with well-pronounced immunosuppressive properties, allowing them to suppress the activity of effector cells.
Elina A. Zheremyan   +11 more
doaj   +1 more source

Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing

open access: yesNature Communications, 2020
CRISPR-Cas9 has emerged as a powerful technology that relies on Cas9/sgRNA ribonucleoprotein complexes (RNPs) to target and edit DNA. However, many therapeutic targets cannot currently be accessed due to the lack of carriers that can deliver RNPs ...
Tuo Wei   +4 more
semanticscholar   +1 more source

Whole genome MBD-seq and RRBS analyses reveal that hypermethylation of gastrointestinal hormone receptors is associated with gastric carcinogenesis

open access: yesExperimental and Molecular Medicine, 2018
Stomach cancer: DNA methylation of hormone receptor genes A sequencing study reveals abnormal changes to DNA that set the stage for stomach cancer development.
Hee-Jin Kim   +9 more
doaj   +1 more source

CRISPR/Cas9 editing of endogenous banana streak virus in the B genome of Musa spp. overcomes a major challenge in banana breeding [PDF]

open access: yes, 2020
Open Access Journal; Published online: 31 Jan 2019Presence of the integrated endogenous banana streak virus (eBSV) in the B genome of plantain (AAB) is a major challenge for breeding and dissemination of hybrids.
Britt, A.   +5 more
core   +1 more source

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