Results 61 to 70 of about 1,979,376 (400)
Genome edited sheep and cattle [PDF]
Transgenic Research, 2014 Genome editing tools enable efficient and accurate genome manipulation. An enhanced ability to modify the genomes of livestock species could be utilized to improve disease resistance, productivity or breeding capability as well as the generation of new biomedical models. To date, with respect to the direct injection of genome editor mRNA into livestock
Proudfoot, Christopher +10 more
openaire +4 more sources
Comprehensive assessment of miniature CRISPR-Cas12f nucleases for gene disruption
Nature Communications, 2022 CRISPR-Cas12f nucleases can be effectively packaged into AAVs for gene therapy, but a systematic evaluation of editing outcomes is lacking. Here the authors perform a comprehensive assessment of 4 Cas12f proteins and compare to Cas9 and two Cas12a ...
Changchang Xin +6 more
doaj +1 more source
An NgAgo tool for genome editing: did CRISPR/Cas9 just find a competitor? [PDF]
, 2016 While CRISPR/Cas9-mediated genome editing technology has been experiencing a rapid transformation during the past few years, a recent report on NgAgo-mediated single-stranded DNA-guided genome editing may offer an attractive alternative for genome ...
Haydon, Rex C. +8 more
core +1 more source
The Role of Recombinant AAV in Precise Genome Editing
Frontiers in Genome Editing, 2022 The replication-defective, non-pathogenic, nearly ubiquitous single-stranded adeno-associated viruses (AAVs) have gained importance since their discovery about 50 years ago.
Swati Bijlani +4 more
semanticscholar +1 more source
Breakthrough to genome editing [PDF]
Science, 2015 A, T, G, C: the alphabet code for the nucleotides that are the building blocks of life. Minor, but consequential, changes in this DNA coding can change gene function. Researchers have long sought better ways to edit the genetic code in cultured cells and laboratory organisms to silence, activate, or change targeted genes to gain a better ...
openaire +3 more sources
Editing the Mitochondrial Genome
New England Journal of Medicine, 2020 Mending Mitochondrial Mutation For most patients with mitochondrial disorders, most of which are caused by mutations in genes in the mitochondrial genome, only symptomatic treatment is available.
Maria Falkenberg, Michio Hirano
openaire +3 more sources
Frontiers in Immunology, 2023 Regulatory B lymphocytes (Bregs) are B cells with well-pronounced immunosuppressive properties, allowing them to suppress the activity of effector cells.
Elina A. Zheremyan +11 more
doaj +1 more source
Nature Communications, 2020 CRISPR-Cas9 has emerged as a powerful technology that relies on Cas9/sgRNA ribonucleoprotein complexes (RNPs) to target and edit DNA. However, many therapeutic targets cannot currently be accessed due to the lack of carriers that can deliver RNPs ...
Tuo Wei +4 more
semanticscholar +1 more source
Experimental and Molecular Medicine, 2018 Stomach cancer: DNA methylation of hormone receptor genes A sequencing study reveals abnormal changes to DNA that set the stage for stomach cancer development.
Hee-Jin Kim +9 more
doaj +1 more source
CRISPR/Cas9 editing of endogenous banana streak virus in the B genome of Musa spp. overcomes a major challenge in banana breeding [PDF]
, 2020 Open Access Journal; Published online: 31 Jan 2019Presence of the integrated endogenous banana streak virus (eBSV) in the B genome of plantain (AAB) is a major challenge for breeding and dissemination of hybrids.
Britt, A. +5 more
core +1 more source