Results 131 to 140 of about 526,413 (332)

Portable CRISPR-Cas9 ^N System for Flexible Genome Engineering in Lactobacillus acidophilus, Lactobacillus gasseri, and Lactobacillus paracasei

, 2021
Yong Jun Goh, Rodolphe Barrangou
openalex   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Lipofection of Non-integrative CRISPR/Cas9 Ribonucleoproteins in Male Germline Stem Cells: A Simple and Effective Knockout Tool for Germline Genome Engineering [PDF]

, 2022
Mariella Obermeier, Jim Vadolas, Stefaan Verhulst, Ellen Goossens, Yoni Baert   +4 more
openalex   +1 more source

The Failure of Federal Biotechnology Regulation [PDF]

, 2017
The recent court case and state ballot measures regarding mandatory labels for Genetically Modified Organisms (“GMOs”) suggest the need for a deeper conversation about the federal framework for regulating biotechnology.
Peck, Alison
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

324. Multiplex CRISPR/Cas9-Based Genome Engineering from a Single Lentiviral Vector [PDF]

, 2014

openalex   +1 more source

Production of Living Nanoparticles for Blood Cancer Therapy [PDF]

, 2018
Current cancer therapies leave much to be desired because they are very harmful to the patient and cause a significant decrease in quality of life. Chimeric Antigen Receptors (CAR) are a promising novel approach for treating specific types of leukemia ...
Mitchell, Peter, Pierotti, Michael, Piro, Matthew   +2 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

CRISPR-Cas9 Mediated Gene Editing: A Revolution in Genome Engineering [PDF]

, 2017
Shilpa Sampathi, P Horvath, R Barrangou, J Garneau, M Dupuis, M Villion, D Romero, R Barrangou, Le Cong, F, Ann Ran, David Cox, Shuailiang Lin, Robert Barretto, W Jiang, D Bikard, D Cox, F Zhang, L Marraffini, H Yang, H Wang, C Shivalila, A Cheng, L Shi, J Sander, J Joung, P Mali, K Esvelt, G Church, P Hsu, D Scott, J Weinstein, F Ran, S Konermann, F Ran, P Hsu, C Lin, J Gootenberg, S Konermann, J Kim, D Kim, S Kim, J Kim, I Lokody, Vikram Pattanayak, Steven Lin, John Guilinger, Enbo Ma, Jennifer Doudna, Abba Malina, John Mills, Regina Cencic, Yifei Yan, James Fraser, A Xiao, Z Wang, Y Hu, Y Wu, Z Luo, G Amitai, R Sorek, M Bolukbasi, A Gupta, S Wolfe, T Auer, K Duroure, A De Cian, J Concordet, Del Bene, F, R Deans, D Morgens, A kesli, S Pillay, M Horlbeck, D Du, L Qi, Y Guo, Q Xu, D Canzio, J Shou, J Li   +81 more
openalex   +1 more source

Discovery of Diverse CRISPR-Cas Systems and Expansion of the Genome Engineering Toolbox [PDF]

, 2023
Eugene V. Koonin, Jonathan S. Gootenberg, Omar O. Abudayyeh   +2 more
openalex   +1 more source