Results 151 to 160 of about 3,929,879 (390)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

DNA on the move: mechanisms, functions and applications of transposable elements

FEBS Open Bio
Transposons are mobile genetic elements that have invaded all domains of life by moving between and within their host genomes. Due to their mobility (or transposition), transposons facilitate horizontal gene transfer in bacteria and foster the evolution ...
Michael Schmitz, Irma Querques
doaj   +1 more source

Engineering the Drosophila Genome for Developmental Biology

Journal of Developmental Biology, 2017
The recent development of transposon and CRISPR-Cas9-based tools for manipulating the fly genome in vivo promises tremendous progress in our ability to study developmental processes.
Dagmara Korona, Stefan A. Koestler, Steven Russell   +2 more
doaj   +1 more source

Genealogical Distance as a Diversity Estimate in Evolutionary Algorithms

, 2017
The evolutionary edit distance between two individuals in a population, i.e., the amount of applications of any genetic operator it would take the evolutionary process to generate one individual starting from the other, seems like a promising estimate ...
Belzner, Lenz, Gabor, Thomas
core   +1 more source

CRISPR-Cas9 Mediated Gene Editing: A Revolution in Genome Engineering [PDF]

, 2017
Shilpa Sampathi, P Horvath, R Barrangou, J Garneau, M Dupuis, M Villion, D Romero, R Barrangou, Le Cong, F, Ann Ran, David Cox, Shuailiang Lin, Robert Barretto, W Jiang, D Bikard, D Cox, F Zhang, L Marraffini, H Yang, H Wang, C Shivalila, A Cheng, L Shi, J Sander, J Joung, P Mali, K Esvelt, G Church, P Hsu, D Scott, J Weinstein, F Ran, S Konermann, F Ran, P Hsu, C Lin, J Gootenberg, S Konermann, J Kim, D Kim, S Kim, J Kim, I Lokody, Vikram Pattanayak, Steven Lin, John Guilinger, Enbo Ma, Jennifer Doudna, Abba Malina, John Mills, Regina Cencic, Yifei Yan, James Fraser, A Xiao, Z Wang, Y Hu, Y Wu, Z Luo, G Amitai, R Sorek, M Bolukbasi, A Gupta, S Wolfe, T Auer, K Duroure, A De Cian, J Concordet, Del Bene, F, R Deans, D Morgens, A kesli, S Pillay, M Horlbeck, D Du, L Qi, Y Guo, Q Xu, D Canzio, J Shou, J Li   +81 more
openalex   +1 more source

Engineering modification of genome-reduced strain Bacillus amyloliquefaciens for enhancing surfactin production [PDF]

, 2020
Fang Zhang, Kaiyue Huo, Xingyi Song, Yufen Quan, Weixia Gao, Shufang Wang, Chao Yang   +6 more
openalex   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Production of Living Nanoparticles for Blood Cancer Therapy [PDF]

, 2018
Current cancer therapies leave much to be desired because they are very harmful to the patient and cause a significant decrease in quality of life. Chimeric Antigen Receptors (CAR) are a promising novel approach for treating specific types of leukemia ...
Mitchell, Peter, Pierotti, Michael, Piro, Matthew   +2 more
core   +1 more source

Engineering the Direct Repeat Sequence of crRNA for Optimization of FnCpf1-Mediated Genome Editing in Human Cells [PDF]

, 2018
Lin Li, Xiubin He, Tianyuan Zhao, Lingkai Gu, Yeqing Liu, Xiaoyu Liu, Hongyan Liu, Fayu Yang, Mengjun Tu, Lianchao Tang, Xianglian Ge, Changbao Liu, Junzhao Zhao, Zongming Song, Jia Qu, Feng Gu   +15 more
openalex   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source