Results 131 to 140 of about 3,929,879 (390)
Base editors: a powerful tool for generating animal models of human diseases
Cell Stress, 2018 Myriads of genetic mutations, including base substitutions, deletions, and insertions as well as chromosome structural variations, have been detected in many human diseases.
Zongyang Lu, Xingxu Huang
doaj +1 more source
bioRxiv, 2019 Establishment of production platform organisms through prokaryotic engineering represents an efficient means to generate alternatives for yielding renewable biochemicals and biofuels from sustainable resources.
Yanli Zheng +11 more
semanticscholar +1 more source
Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies.
Cell, 2020 Adoptive transfer of genetically modified immune cells holds great promise for cancer immunotherapy. CRISPR knockin targeting can improve cell therapies, but more high-throughput methods are needed to test which knockin gene constructs most potently ...
Theodore L. Roth +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Synthetic and Engineering Biology in Australia: Advances in Infrastructure, Coordination and Impact
Engineering BiologySynthetic and engineering biology in Australia is a vibrant and expanding area, with the potential to contribute to Australian priorities, industry growth and international initiatives.
Robert E. Speight
doaj +1 more source
Synthetic Biology: A Bridge between Artificial and Natural Cells. [PDF]
, 2014 Artificial cells are simple cell-like entities that possess certain properties of natural cells. In general, artificial cells are constructed using three parts: (1) biological membranes that serve as protective barriers, while allowing communication ...
Ding, Yunfeng, Tan, Cheemeng, Wu, Fan
core +2 more sources
Microbial Biotechnology, 2019 Pseudomonas species have become reliable platforms for bioproduction due to their capability to tolerate harsh conditions imposed by large‐scale bioprocesses and their remarkable resistance to diverse physicochemical stresses.
Nicolas T. Wirth +2 more
semanticscholar +1 more source
CRISPR-Cas: Revolutionising genome engineering
South African Medical Journal, 2016 The ability to permanently alter or repair the human genome has been the subject of a number of science fiction films, but with the recent advent of several customisable sequence-specific endonuclease technologies, genome engineering looks set to become a clinical reality in the near future.
Nicholson, S.A., Pepper, Michael Sean
openaire +6 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source