Results 171 to 180 of about 3,929,879 (390)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

E-TALEN: a web tool to design TALENs for genome engineering [PDF]

, 2013
Florian Heigwer, Gráinne Kerr, Nike Walther, Kathrin Glaeser, Oliver Pelz, Marco Breinig, Michael Boutros   +6 more
openalex   +1 more source

Review of: "RNA targeting with CRISPR-Cas13a facilitates bacteriophage genome engineering" [PDF]

, 2022
David Parker
openalex   +1 more source

Bacteriophage genome engineering with CRISPR–Cas13a

Nature Microbiology, 2022
J. Guan, Agnès Oromí-Bosch, Senén D Mendoza, Shweta Karambelkar, Joel D. Berry, Joseph Bondy-Denomy   +5 more
semanticscholar   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Molecular Engineering of the Autographa californica Nuclear Polyhedrosis Virus Genome: Deletion Mutations Within the Polyhedrin Gene [PDF]

, 1983
Gale Smith, Malcolm J. Fraser, Max D. Summers   +2 more
openalex   +1 more source

A multiplex guide RNA expression system and its efficacy for plant genome engineering [PDF]

, 2020
Youngbin Oh, Hyeonjin Kim, Bora Lee, Sang‐Gyu Kim   +3 more
openalex   +1 more source

Multiplex Genome Engineering Using CRISPR/Cas Systems

Science, 2013
Le Cong, F. Ran, David B. T. Cox, Shuailiang Lin, Robert Barretto, Naomi Habib, P. Hsu, Xuebing Wu, Wenyan Jiang, L. Marraffini, Feng Zhang   +10 more
semanticscholar   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

New Scientific and Technological Developments of Relevance to the Fifth Review Conference [PDF]

, 2001
Ye
Pearson, Graham S.
core