Results 221 to 230 of about 526,413 (332)

Efficient engineering of a bacteriophage genome using the type I-E CRISPR-Cas system [PDF]

, 2014
Ruth Kiro, Dror Shitrit, Udi Qimron
openalex   +1 more source

Diagnostic Utility of the ATG9A Ratio in AP‐4–Associated Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adaptor protein complex 4–associated hereditary spastic paraplegia (AP‐4‐HSP), a childhood‐onset neurogenetic disorder and frequent mimic of cerebral palsy, is caused by biallelic variants in the adaptor protein complex 4 (AP‐4) subunit genes (AP4B1 [for SPG47], AP4M1 [for SPG50], AP4E1 [for SPG51], and AP4S1 [for SPG52]).
Habibah A. P. Agianda, Hyo‐Min Kim, Nicole Battaglia, Joshua Rong, Amy Tam, Enrique Gonzalez Saez‐Diez, Cornelius F. Boerkoel, Afshin Saffari, Vicente Quiroz, Luca Schierbaum, Zainab Zaman, Katerina Bernardi, Darius Ebrahimi‐Fakhari   +12 more
wiley   +1 more source

Programming virulent bacteriophages by developing a multiplex genome engineering method. [PDF]

mBio
Zhang H, Zhu R, Wang Z, He R, Zhang Y, Luan J, Yan Y, Zhang Y, Wang H.   +8 more
europepmc   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Mouse genome engineering uncovers 18 genes dispensable for male reproduction. [PDF]

Andrology
Chang HY, Lu Y, Yamamoto K, Sun J, Shimada K, Hiradate Y, Fujihara Y, Ikawa M.   +7 more
europepmc   +1 more source

659. Precision Genome Engineering in Human Induced Pluripotent Stem Cells Using CRISPR/CAS9 [PDF]

, 2015
Jon P. Connelly, Amber Neilson, Sam T. Peters, Rita Martinez, Jeffrey Milbrandt, Shondra Miller   +5 more
openalex   +1 more source

TBK1‐Associated Primary Lateral Sclerosis Followed by Right Temporal Variant Frontotemporal Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We report a 58‐year‐old woman with a novel splice‐site variant in the TANK‐binding kinase 1 (TBK1:c.993–2A>C p.Ala332TyrfsTer39) who sequentially developed primary lateral sclerosis (PLS) followed by right temporal variant frontotemporal dementia (rtvFTD). Neuroimaging demonstrated right anterior temporal atrophy before cognitive symptoms, and
Tomoyasu Matsubara, Naoki Kihara, Satoko Miyatake, Koji Fujita, Konoka Tachibana, Ryosuke Miyamoto, Hiroki Yamazaki, Yusuke Osaki, Nazere Keyoumu, Yuki Kuwano, Nobutoshi Morimoto, Suzuran Saito, Eriko Koshimizu, Yoichi Otomi, Kenji Ishibashi, Masafumi Harada, Naomichi Matsumoto, Hiroyuki Morino, Yuishin Izumi   +18 more
wiley   +1 more source

Make-or-break prime editing for genome engineering in Streptococcus pneumoniae. [PDF]

Nat Commun
Rengifo-Gonzalez M, Mazzuoli MV, Janssen AB, Rueff AS, Burnier J, Liu X, Veening JW.   +6 more
europepmc   +1 more source

Development of a CRISPR-Cas12a system for efficient genome engineering in clostridia. [PDF]

Microbiol Spectr, 2023
Zhang Y, Kubiak AM, Bailey TS, Claessen L, Hittmeyer P, Dubois L, Theys J, Lambin P.   +7 more
europepmc   +1 more source

Genome Engineering and Agriculture: Opportunities and Challenges

, 2017
Nicholas J. Baltes, Javier Gil‐Humanes, Daniel F. Voytas   +2 more
openalex   +2 more sources