Results 201 to 210 of about 3,929,879 (390)

Lean-proteome strains – next step in metabolic engineering

Frontiers in Bioengineering and Biotechnology, 2015
Kaspar eValgepea, Karl ePeebo, Karl ePeebo, Kaarel eAdamberg, Kaarel eAdamberg, Raivo eVilu, Raivo eVilu   +6 more
doaj   +1 more source

Bioinformatics-Based Identification of Human B-Cell Receptor (BCR) Stimulation-Associated Genes and Putative Promoters

BioMedInformatics
Genome engineered B-cells are being developed for chronic, systemic in vivo protein replacement therapies and for localized, tumor cell-actuated anticancer therapeutics.
Ethan Deitcher, Kirk Trisler, Branden S. Moriarity, Caleb J. Bostwick, Fleur A. D. Leenen, Steven R. Deitcher   +5 more
doaj   +1 more source

Discovery of Diverse CRISPR-Cas Systems and Expansion of the Genome Engineering Toolbox [PDF]

, 2023
Eugene V. Koonin, Jonathan S. Gootenberg, Omar O. Abudayyeh   +2 more
openalex   +1 more source

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering.

Cell, 2013
Haoyi Wang, Hui Yang, C. Shivalila, Meelad M. Dawlaty, A. Cheng, Feng Zhang, R. Jaenisch   +6 more
semanticscholar   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Alpha-synuclein in Parkinson's disease: molecular pathogenesis and development of genome engineering-based silencing approaches

, 2015
Sabrina M. Heman-Ackah
openalex   +1 more source

Genetic Engineering and Genome Editing Advances to Enhance Floral Attributes in Ornamental Plants: An Update [PDF]

, 2023
Manjulatha Mekapogu, Hyun-Young Song, So-Hyeon Lim, Jae‐A Jung   +3 more
openalex   +1 more source

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering.

Trends in Biotechnology, 2013
T. Gaj, C. Gersbach, C. Barbas
semanticscholar   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source