Results 221 to 230 of about 3,929,879 (390)

Author Correction: Engineering monocyte/macrophage−specific glucocerebrosidase expression in human hematopoietic stem cells using genome editing [PDF]

, 2020
Samantha G. Scharenberg, Édina Poletto, Katherine L. Lucot, Pasqualina Colella, Adam Sheikali, Thomas J. Montine, Matthew H. Porteus, Natalia Gomez‐Ospina   +7 more
openalex   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Efficient engineering of a bacteriophage genome using the type I-E CRISPR-Cas system [PDF]

, 2014
Ruth Kiro, Dror Shitrit, Udi Qimron
openalex   +1 more source

Hybrid ssDNA repair templates enable high yield genome engineering in primary cells for disease modeling and cell therapy manufacturing [PDF]

, 2021
Brian R. Shy, Vivasvan S. Vykunta, Alvin Ha, Theodore L. Roth, Alexis Talbot, David N. Nguyen, Yan Yi Chen, Franziska Blaeschke, Shane Vedova, Murad R. Mamedov, Jing-Yi Chung, Hong Li, Jeffrey L. Wolf, Thomas Martin, Lumeng Ye, Justin Eyquem, Jonathan H. Esensten, Alexander Marson   +17 more
openalex   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

A compact Cascade–Cas3 system for targeted genome engineering

Nature Methods, 2020
Bálint Csörgő, Lina M. Leon, Ilea J. Chau-Ly, Alejandro Vasquez-Rifo, Joel D. Berry, C. Mahendra, E. Crawford, J. D. Lewis, Joseph Bondy-Denomy   +8 more
semanticscholar   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Editorial: Forest genomics and biotechnology [PDF]

, 2019
Allona, Isabel, Boerjan, Wout, Kirst, Matias, Sederoff, Ronald, Strauss, Steven   +4 more
core   +1 more source

Engineering the Delivery System for CRISPR-Based Genome Editing

, 2018
Zachary Glass, Matthew Lee, Yamin Li, Qiaobing Xu   +3 more
openalex   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source