Results 241 to 250 of about 526,413 (332)

Genome engineering with Cas9 and AAV repair templates, successes and pitfalls. [PDF]

Mamm Genome
Birling MC, Hérault Y, Pavlovic G.
europepmc   +1 more source

Beyond Nature? Genomic Modification and the Future of Humanity [PDF]

, 2018
Mahoney, Julia D., Siegal, Gil
core   +1 more source

Combinatorial Synthesis of Next Generation Water‐Soluble Quaternized N‐Halamine Oligomers with Long‐Lasting Antiviral Properties

Advanced Functional Materials, EarlyView.
A combinatorial library of dual‐functional antiviral oligomers incorporating N‐halamine and quaternary ammonium functionalities is developed for long‐lasting antiviral activity. The lead materials exhibit rapid and durable antiviral activity against SARS‐CoV‐2 variants and influenza H1N1, with 4 to 5 log reduction in viral copies at 5 mg mL−1 ...
Eid Nassar‐Marjiya, Konda Reddy Kunduru, Krishanu Ghosal, Luna Rizik, Nofar Atari, Mahran Daifa, Neta Kutner, Bassma Khamaisi, Qi Wu, Simran Jindal, Merna Shaheen‐Mualim, Ranabir Majumder, Mahitosh Mandal, Michal Mandelboim, Shady Farah   +14 more
wiley   +1 more source

Dual-pronged genome engineering: Enhancing crop resistance through elite allele pyramiding and susceptibility gene editing. [PDF]

IMetaOmics
Zeng Q, Kang Z.
europepmc   +1 more source

In silico identification of metabolic engineering strategies for improved lipid production in Yarrowia lipolytica by genome-scale metabolic modeling [PDF]

, 2019
Minsuk Kim, Beom Gi Park, Eun-Jung Kim, Joonwon Kim, Byung‐Gee Kim   +4 more
openalex   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Three's company: Simultaneous trimodal genome engineering using orthologous Cas proteins. [PDF]

Mol Ther
Brooks IR, Jacków-Malinowska J.
europepmc   +1 more source

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

Controlling 3D Contractility via Engineered Fibrous Hydrogel Composites

Advanced Functional Materials, EarlyView.
A tunable composite contractile assembly (CCA) is developed that can permit or resist contraction without changing cell‐adhesion and density, unlike collagen whose inherent coupling of these ECM cues limits its use as a platform in contractility studies.
Karen L. Xu, Yuqi Zhang, Alysse DeFoe, Georgios Kotsaris, Brendan Stoeckl, Matthew D. Davidson, Jason A. Burdick, Robert L. Mauck   +7 more
wiley   +1 more source

A rapid and efficient red-light-activated Cre recombinase system for genome engineering in mammalian cells and transgenic mice. [PDF]

Nucleic Acids Res
Zhou Y, Wei Y, Yin J, Kong D, Li W, Wang X, Yao Y, Huang Q, Li L, Liu M, Qiao L, Li H, Zhao J, Zhong TP, Li D, Duan L, Guan N, Ye H.   +17 more
europepmc   +1 more source