Results 61 to 70 of about 874,950 (354)

Current status of the multinational Arabidopsis community

Plant Direct, 2020
The multinational Arabidopsis research community is highly collaborative and over the past thirty years these activities have been documented by the Multinational Arabidopsis Steering Committee (MASC). Here, we (a) highlight recent research advances made
Geraint Parry, Nicholas J. Provart, Siobhan M. Brady, Baris Uzilday, The Multinational Arabidopsis Steering Committee   +4 more
doaj   +1 more source

Evolution of genome sequencing techniques [PDF]

, 2016
The quality and the speed for genome sequencing has advanced at the same time that technology boundaries are stretched. This advancement has been divided so far in three generations.
Goebel Vázquez, Cristina, Henao Mejía, Luisa Maria   +1 more
core  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Factors driving metabolic diversity in the budding yeast subphylum

BMC Biology, 2018
Background Associations between traits are prevalent in nature, occurring across a diverse range of taxa and traits. Individual traits may co-evolve with one other, and these correlations can be driven by factors intrinsic or extrinsic to an organism ...
Dana A. Opulente, Emily J. Rollinson, Cleome Bernick-Roehr, Amanda Beth Hulfachor, Antonis Rokas, Cletus P. Kurtzman, Chris Todd Hittinger   +6 more
doaj   +1 more source

Clonal heterogeneity in ER+ breast cancer reveals the proteasome and PKC as potential therapeutic targets

npj Breast Cancer, 2023
Intratumoral heterogeneity impacts the success or failure of anti-cancer therapies. Here, we investigated the evolution and mechanistic heterogeneity in clonal populations of cell models for estrogen receptor positive breast cancer.
Lukas Beumers, Efstathios-Iason Vlachavas, Simone Borgoni, Luisa Schwarzmüller, Luca Penso-Dolfin, Birgitta E. Michels, Emre Sofyali, Sara Burmester, Daniela Heiss, Heike Wilhelm, Yosef Yarden, Dominic Helm, Rainer Will, Angela Goncalves, Stefan Wiemann   +14 more
doaj   +1 more source

Law of Genome Evolution Direction : Coding Information Quantity Grows

, 2008
The problem of the directionality of genome evolution is studied. Based on the analysis of C-value paradox and the evolution of genome size we propose that the function-coding information quantity of a genome always grows in the course of evolution ...
A. F. A. Smit, A. G. Matera, A. Mira, B. Charlesworth, C. L. Organ, C. Nusbaum, D. A. Petrov, D. L. Marais Des, D. R. Scannell, E. Schrodinger, E. T. Dermitzakis, F. Clark, G. Bejerano, G. Liu, G. Storz, H. H. Chou, H. H. Kazazian, H. Ozkan, H. Winter, I. J. Leitch, I. Wapinski, I. Wickelgren, International Human Genome Sequencing Consortium, J. Filkowski, J.M. Aury, K. M. Devos, L. F. Luo, L. F. Luo, L. F. Luo, L. He, L. Patthy, L. R. Zhang, Liao-fu Luo, R. J. Taft, R. P. Bininda-Edmonds, S. E. Peters, T. C. Stadtman, T. Kouzarides, T. R. Gregory, The ENCODE Project Consortium, W. Deng, W. Enard, W. H. Li, W. Makalowski, X. Xu   +44 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Navigating the archaeal frontier: insights and projections from bioinformatic pipelines

Frontiers in Microbiology
Archaea continues to be one of the least investigated domains of life, and in recent years, the advent of metagenomics has led to the discovery of many new lineages at the phylum level.
Val Karavaeva, Val Karavaeva, Filipa L. Sousa   +2 more
doaj   +1 more source

A chemical genetic screen identifies Aurora kinases as a therapeutic target in EGFR T790M negative, gefitinib-resistant head and neck squamous cell carcinoma (HNSCC)

EBioMedicine, 2021
Background: Overexpression of epidermal growth factor receptor (EGFR), and downstream pathway activation appears to be a common oncogenic driver in the majority of head and neck squamous cell cancers (HNSCCs); yet targeting EGFR for the treatment of ...
Joo-Leng Low, Dawn Pingxi Lau, Xiaoqian Zhang, Xue-Lin Kwang, Neha Rohatgi, Jane Vin Chan, Fui-Teen Chong, Stephen Qi Rong Wong, Hui-Sun Leong, Matan Thangavelu Thangavelu, Shivaji Rikka, Anders Martin Jacobsen Skanderup, Daniel Shao Weng Tan, Giridharan Periyasamy, Judice Lie Yong Koh, N Gopalakrishna Iyer, Ramanuj DasGupta   +16 more
doaj   +1 more source

Solving the riddle of codon usage preferences: a test for translational selection [PDF]

, 1998
Translational selection is responsible for the unequal usage of synonymous codons in protein coding genes in a wide variety of organisms. It is one of the most subtle and pervasive forces of molecular evolution, yet, establishing the underlying causes ...
A Kaminskii, AE Siegman, G Lu, JR Leger, K Kubodera, K Kubodera, ME Innocenzi, P Laporta, S Yamaguchi, SC Tidwell, TY Fan, U Brauch, W Koechner, WA Clarkson, WA Clarkson, WA Clarkson, WP Risk, Y Guyot   +17 more
core   +3 more sources