Results 11 to 20 of about 155,866 (241)

Bacterial Genome Instability [PDF]

Microbiology and Molecular Biology Reviews, 2014
SUMMARY Bacterial genomes are remarkably stable from one generation to the next but are plastic on an evolutionary time scale, substantially shaped by horizontal gene transfer, genome rearrangement, and the activities of mobile DNA elements. This implies the existence of a delicate balance between the maintenance of genome stability and the ...
Elise, Darmon, David R F, Leach
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Genome Instability and γH2AX [PDF]

International Journal of Molecular Sciences, 2017
γH2AX has emerged in the last 20 years as a central player in the DDR (DNA damage response), with specificity for DSBs (double-strand breaks). Upon the generation of DSBs, γ-phosphorylation extends along megabase-long domains in chromatin, both sides of the damage.
Georgoulis, A., Vorgias, C.E., Chrousos, G.P., Rogakou, E.P.   +3 more
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Methylation of KRAS by SETD7 promotes KRAS degradation in non-small cell lung cancer

Cell Reports, 2023
Summary: Oncogenic KRAS mutations are a key driver for initiation and progression in non-small cell lung cancer (NSCLC). However, how post-translational modifications (PTMs) of KRAS, especially methylation, modify KRAS activity remain largely unclear ...
Cheng-Yao Chiang, Songqing Fan, Hongmei Zheng, Wenjun Guo, Zehan Zheng, Yihua Sun, Chuanqi Zhong, Juan Zeng, Shuaihu Li, Min Zhang, Tian Xiao, Duo Zheng   +11 more
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Locus specific engineering of tandem DNA repeats in the genome of Saccharomyces cerevisiae using CRISPR/Cas9 and overlapping oligonucleotides

Scientific Reports, 2018
DNA repeats constitute a large part of genomes of multicellular eucaryotes. For a longtime considered as junk DNA, their role in genome organization and tuning of gene expression is being increasingly documented.
Astrid Lancrey, Alexandra Joubert, Jean-Baptiste Boulé   +2 more
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RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma

Nature Communications, 2022
Mutations in RAS oncogenes and related pathways are frequent in lung cancers. Here, the authors derive a RAS gene expression signature and a machine learning classifier to predict drug response and clinical outcomes in lung adenocarcinoma and other solid
Philip East, Gavin P. Kelly, Dhruva Biswas, Michela Marani, David C. Hancock, Todd Creasy, Kris Sachsenmeier, Charles Swanton, TRACERx consortium, Julian Downward, Sophie de Carné Trécesson   +10 more
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Molecular Docking for the Development of Alternative Therapies against Leishmaniasis

Chemistry Proceedings, 2023
Topoisomerases play a pivotal role in regulating the topological structure of DNA during fundamental processes such as transcription, DNA repair, or DNA replication; because of this, topoisomerases are biological targets in pathogenic microorganisms or ...
Juan Diego Guarimata, Christian Alcívar, Martin Lavecchia, Ana Poveda   +3 more
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Escape from nonsense-mediated decay associates with anti-tumor immunogenicity

Nature Communications, 2020
The transcripts generated by frameshifts and indels in cancer are frequently degraded by nonsense mediated decay. Here, the authors show that some of these transcripts can escape this degradation mechanism and their prevalence correlates with tumour ...
Kevin Litchfield, James L. Reading, Emilia L. Lim, Hang Xu, Po Liu, Maise Al-Bakir, Yien Ning Sophia Wong, Andrew Rowan, Samuel A. Funt, Taha Merghoub, David Perkins, Martin Lauss, Inge Marie Svane, Göran Jönsson, Javier Herrero, James Larkin, Sergio A. Quezada, Matthew D. Hellmann, Samra Turajlic, Charles Swanton   +19 more
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Genomic Instability in Cancer [PDF]

Cold Spring Harbor Perspectives in Biology, 2013
One of the fundamental challenges facing the cell is to accurately copy its genetic material to daughter cells. When this process goes awry, genomic instability ensues in which genetic alterations ranging from nucleotide changes to chromosomal translocations and aneuploidy occur.
Tarek, Abbas, Mignon A, Keaton, Anindya, Dutta   +2 more
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Editorial: Genomic Instability and Neurodegeneration [PDF]

Frontiers in Aging Neuroscience, 2022
No abstract ...
Julia Fuchs, Bjoern Schwer, Bjoern Schwer, Bjoern Schwer, Bjoern Schwer, Sherif F. El-Khamisy, Sherif F. El-Khamisy   +6 more
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Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis

Nature Communications, 2020
Targeting self-renewing cancer cells without deleterious side effects in normal tissues has proven challenging. Here, the authors show that the well-tolerated HDAC inhibitor Quisinostat safely inhibits tumor maintenance and disease relapse by restoring ...
Cristina Morales Torres, Mary Y. Wu, Sebastijan Hobor, Elanor N. Wainwright, Matthew J. Martin, Harshil Patel, William Grey, Eva Grönroos, Steven Howell, Joana Carvalho, Ambrosius P. Snijders, Michael Bustin, Dominique Bonnet, Paul D. Smith, Charles Swanton, Michael Howell, Paola Scaffidi   +16 more
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