Results 91 to 100 of about 1,743,586 (380)

Interpreting Microbial Biosynthesis in the Genomic Age: Biological and Practical Considerations

Marine Drugs, 2017
Genome mining has become an increasingly powerful, scalable, and economically accessible tool for the study of natural product biosynthesis and drug discovery.
Ian J. Miller, Marc G. Chevrette, Jason C. Kwan   +2 more
doaj   +1 more source

Increased Biological Activity of Aneurinibacillus migulanus Strains Correlates with the Production of New Gramicidin Secondary Metabolites [PDF]

, 2017
Acknowledgments This project was funded by the Government of Kuwait (to FA) and the European Union Seventh Framework Programme under grant agreement 245268 (ISEFOR; to LB and SW).
Alenezi, Faizah N., Belbahri, Lassaad, Bouket, Ali Chenari, Jaspars, Marcel, Luptakova, Lenka, Rateb, Mostafa E., Rekik, Imen, Weitz, Hedda, Woodward, Stephen   +8 more
core   +1 more source

Mining the Bovine Genome with the “Bovine SNP Retriever” [PDF]

Journal of Heredity, 2008
Online resources for the bovine genome analysis are provided at the most important Web sites. Nonetheless, retrieval of single-nucleotide polymorphism (SNP)-related information is not always easy when searches must focus on complementary features. In this work, we present the Bovine SNP Retriever: a user-friendly tool for bovine SNP retrieval that also
Panzitta Francesca, Caprera Andrea, Merelli Ivan, Milanesi Luciano, Williams John L, Lazzari Barbara, Stella Alessandra   +6 more
openaire   +8 more sources

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

Molecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou, Aliki Ntzifa, Victoria Tserpeli, Ioanna Balgkouranidou, Alkistis Papatheodoridi, Evangelia Razis, Helena Linardou, Christos Papadimitriou, Amanda Psyrri, Flora Zagouri, Stylianos Kakolyris, Evi Lianidou   +11 more
wiley   +1 more source

Expanding the Utility of Bioinformatic Data for the Full Stereostructural Assignments of Marinolides A and B, 24- and 26-Membered Macrolactones Produced by a Chemically Exceptional Marine-Derived Bacterium

Marine Drugs, 2023
Marinolides A and B, two new 24- and 26-membered bacterial macrolactones, were isolated from the marine-derived actinobacterium AJS-327 and their stereostructures initially assigned by bioinformatic data analysis.
Min Cheol Kim, Jaclyn M. Winter, Reiko Cullum, Alexander J. Smith, William Fenical   +4 more
doaj   +1 more source

Towards knowledge-based gene expression data mining [PDF]

, 2007
The field of gene expression data analysis has grown in the past few years from being purely data-centric to integrative, aiming at complementing microarray analysis with data and knowledge from diverse available sources. In this review, we report on the
Allison, Andersson, Ashburner, Bar-Joseph, Bar-Joseph, Batagelj, Bernard, Blaž Zupan, Bolshakova, Brown, Cheng, Cheng, Cho, Clayton, Cooper, Curk, Datta, de Jong, D’Haeseleer, Eisen, Falcon, Friedman, Gamberger, Gavin, Geiger, Guo, Hand, Hand, Hastie, Huang, Hughes, Hughes, Hvidsten, Imoto, Jeffery, Jiang, Khan, Khatri, King, Kong, Lai, Le Phillip, Li, Liang, Lin, Mewes, Mitchell, Moskovitch, Nariai, Pan, Prelic, Qin, Raftery, Resnik, Riccardo Bellazzi, Riva, Rousu, Ruepp, Sacchi, Schlitt, Sebastiani, Shahar, Simon, Statnikov, Stuart, Subramanian, Tamada, Tamayo, Troyanskaya, van de Peppel, Van Driessche, Wang, Witten, Xing, Zupan   +74 more
core   +1 more source

Genome Mining of Three Plant Growth-Promoting Bacillus Species from Maize Rhizosphere

Applied Biochemistry and Biotechnology, 2021
Bacillus species genomes are rich in plant growth-promoting genetic elements. Bacillus subtilis and Bacillus velezensis are important plant growth promoters; hence, to further improve their abilities, the genetic elements responsible for these traits ...
O. S. Olanrewaju, M. Ayilara, A. Ayangbenro, O. Babalola   +3 more
semanticscholar   +1 more source

Burkholderia genome mining for nonribosomal peptide synthetases reveals a great potential for novel siderophores and lipopeptides synthesis [PDF]

MicrobiologyOpen, 2016, 5 (3), pp.512 - 526, 2016
Burkholderia is an important genus encompassing a variety of species, including pathogenic strains as well as strains that promote plant growth. We have carried out a global strategy, which combined two complementary approaches. The first one is genome guided with deep analysis of genome sequences and the second one is assay guided with experiments to ...
arxiv   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Genomic Based Analysis of the Biocontrol Species Trichoderma harzianum: A Model Resource of Structurally Diverse Pharmaceuticals and Biopesticides

Journal of Fungi, 2023
Fungi represents a rich repository of taxonomically restricted, yet chemically diverse, secondary metabolites that are synthesised via specific metabolic pathways.
Suhad A. A. Al-Salihi, Fabrizio Alberti
doaj   +1 more source