Results 71 to 80 of about 80,951 (303)
A novel approach for mining polymorphic microsatellite markers in silico [PDF]
, 2011 Hoffman J, Nichols HJ. A novel approach for mining polymorphic microsatellite markers in silico. PLoS ONE. 2011;6(8): e23283.Abstract:
An important emerging application of high-throughput 454 sequencing is the isolation of molecular markers such as ...Joseph I. Hoffman, Hoffman, Joseph ; https://orcid.org/, Hazel Nichols, Nichols, H. J., Nichols Hazel J., Hazel J. Nichols, Joseph I Hoffman, Hazel J Nichols, Hoffman Joseph I. +8 morecore +2 more sourcesUSP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra +16 morewiley +1 more sourceEuroPineDB: a high-coverage web database for maritime pine transcriptome [PDF]
, 2011 Pinus pinaster is an economically and ecologically important species that is becoming a woody gymnosperm model. Its enormous genome size makes whole-genome sequencing approaches are hard to apply.Guevara Morato, Ángeles, Noé Fernández-Pozo, Soto de Viana, Álvaro, Claros, M. Gonzalo, Cervera, Teresa, Fernández-Pozo Noé, Arantxa Flores-Monterroso, Pedro Perdiguero, Ordás, Ricardo,, Perdiguero, Pedro, Carmen Collada, Francisco M Cánovas, Guerrero Fernández, Dario, Álvaro Soto, Perdiguero, Pedro,, Bautista, Rocio, Avila, Concepcion, Díaz-Moreno Sara M, Villalobos David P, Rocío Bautista, Guerrero-Fernández, Darío,, Flores Monterroso, Arantxa, Flores-Monterroso Arantxa, Canales, Javier, Canovas, Francisco M., Collada Carmen, Bautista Rocío, Guerrero-Fernández, Darío, Ordás Ricardo, Avila, C., Diaz Moreno, Sara M., Gonzalo Claros, M., Sara M Díaz-Moreno, Avila, Concepción,, Perdiguero Pedro, Javier Canales, Guerrero Fernandez, Daro, Cervera Goy, María Teresa, Ordás Fernández, Ricardo Javier, Flores-Monterroso, Arantxa,, Cánovas, Francisco M,, Canton, Francisco R., Soto, T., Villalobos, David P,, Villalobos, David P., Concepción Avila, Canales Javier, Cervera, M Teresa,, Cervera M Teresa, Bautista, R., Cantón, Francisco, Guevara M Ángeles, Flores-Monterroso, Arantxa, Francisco R Cantón, Fernández-Pozo, Noé, Collada, Carmen,, Guevara, M. Ángeles, Fernández-Pozo, Noé,, Bautista, Rocío,, Cervera, María Teresa, Soto Álvaro, Cantón, Francisco R,, Collada, Carmen, Díaz-Moreno, Sara M,, Díaz-Moreno, Sara M., Claros, M Gonzalo,, Guerrero-Fernández, D., Soto, Alvaro,, Perdiguero Jimenez, Pedro, Canales, Javier,, Guevara, Ángeles, Cantón Francisco R, M Gonzalo Claros, Guevara, M Ángeles, Cánovas, F. M., Cánovas, Francisco, Claros, Gonzalo, Guevara, M Ángeles,, Ordas, Ricardo, Darío Guerrero-Fernández, Claros M Gonzalo, Ordás, R., Collada Collada, Maria Carmen, David P Villalobos, Soto, Álvaro, Guerrero-Fernández Darío, Villalobos, D. P., M Ángeles Guevara, Avila Concepción, M Teresa Cervera, Fernandez Pozo, Noe, Cánovas Francisco M, Ricardo Ordás +92 morecore +2 more sourcesFinding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer +10 morewiley +1 more sourceThe undiscovered biosynthetic potential of the Greenland Ice Sheet microbiome
Frontiers in Microbiology, 2023 The Greenland Ice Sheet is a biome which is mainly microbially driven. Several different niches can be found within the glacial biome for those microbes able to withstand the harsh conditions, e.g., low temperatures, low nutrient conditions, high UV ...Ate H. Jaarsma, Athanasios Zervas, Katie Sipes, Francisco Campuzano Jiménez, Andrea Claire Smith, Liessel Victoria Svendsen, Mariane S. Thøgersen, Peter Stougaard, Liane G. Benning, Liane G. Benning, Martyn Tranter, Alexandre M. Anesio +11 moredoaj +1 more sourceGenome mining strategies for metallophore discovery
Current Opinion in Biotechnology, 2022 Many bacteria use small-molecule chelators called metallophores to acquire trace metals from their environment. These molecules play a central role in interactions between bacteria, plants, and animals. Hence, knowing their full diversity is key to combatting infectious diseases as well as harnessing beneficial microbial communities.Reitz, Zachary L., Medema, Marnix H.openaire +3 more sourcesThe genome of the obligate intracellular parasite Trachipleistophora hominis : new insights into microsporidian genome dynamics and reductive evolution [PDF]
, 2012 The dynamics of reductive genome evolution for eukaryotes living inside other eukaryotic cells are poorly understood compared to well-studied model systems involving obligate intracellular bacteria.Thomas Weinmaier (124598), Hall, Neil (Department of Functional and Comparative Genomics, School of Biological Sciences, University of Liverpool), Bernhardt Jörg, Robert P Hirt, Hacker Christian, Swan, Daniel C., Robert P. Hirt (124609), Weinmaier, Thomas, Nakjang, Sirintra, Rattei, Thomas, Harris, Simon R. (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Noël Christophe J., Noel, Christophe J., Embley, T. Martin, John M. Lucocq (124603), Christian Hacker (124601), Hirt, Robert P. (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Christophe J. Noël (124592), Lucocq, John M., Stephanie Markert, Tom A. Williams, Embley T. Martin, Neil Hall, Nakjang Sirintra, Williams Tom A., Sirintra Nakjang (124590), Dagan Tal, Martin Embley, John M Lucocq, Rattei, Thomas (University of Vienna), Goldberg Alina V., Tom A Williams, Dagan, Tal (Institute for Molecular Evolution, Heinrich Heine University Düsseldorf), Lucocq John M., Hall Neil, Bernhardt, Jörg, Heinz Eva, Simon R. Harris, Neil Hall (12782), Lucocq, John M. (School of Medicine, University of St Andrews), Noël, Christophe J. (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Weinmaier, Thomas (University of Vienna), Markert, Stephanie (Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald), Tal Dagan, Daniel C. Swan, Sirintra Nakjang, John M. Lucocq, Dörte Becher, Rattei Thomas, Harris Simon R., Daniel C Swan, Christian Hacker, Thomas Rattei (13991), Becher, Dörte, Swan Daniel C., Heinz, Eva (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Weinmaier Thomas, Eva Heinz, Hacker, Christian, Alina V. Goldberg, Simon R Harris, Christophe J. Noël, Thomas Rattei, Eva Heinz (105025), Swan, Daniel C. (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Thomas Weinmaier, Simon R. Harris (124597), Schweder, Thomas (Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald), T Martin Embley, Becher, Doerte, Harris, Simon R., Hacker, Christian (School of Medicine, University of St Andrews), Alina V. Goldberg (124596), Heinz, Eva, Dagan, Tal, Becher Dörte, Markert, Stephanie, Bernhardt, Jörg (Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald), Goldberg, Alina V. (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Schweder Thomas, Hirt, Robert P., T. Martin Embley (124611), Nakjang, Sirintra (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Dörte Becher (90765), Tom A. Williams (124587), Thomas Schweder (124606), Markert Stephanie, Bernhardt, Joerg, Embley, T. Martin (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Williams, Tom A., Hirt Robert P., Alina V Goldberg, Williams, Tom A. (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Jörg Bernhardt (124600), Jörg Bernhardt, Goldberg, Alina V., Schweder, Thomas, Tal Dagan (68513), Robert P. Hirt, Lucocq, John Milton, Hall, Neil, Christophe J Noël, Thomas Schweder, Becher, Dörte (Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald), Daniel C. Swan (124594), Stephanie Markert (124599) +105 morecore +1 more sourceZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach +11 morewiley +1 more source
