Results 91 to 100 of about 80,951 (303)
Advanced Science, EarlyView.In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li +10 more
wiley +1 more source
Genome mining for novel natural product discovery [PDF]
, 2008 Genomics has resulted in the deposition of a huge quantity of DNA sequence data from a wide variety of organisms in publicly accessible databases. Such data can be exploited to generate new knowledge in several areas relevant to medicinal chemistry ...
Challis, Gregory L.
core +1 more source
Advanced Science, EarlyView.A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa +8 more
wiley +1 more source
Marine Drugs, 2020 RES-701-3 and RES-701-4 are two class II lasso peptides originally identified in the fermentation broth of Streptomyces sp. RE-896, which have been described as selective endothelin type B receptor antagonists. These two lasso peptides only differ in the
Daniel Oves-Costales +3 more
doaj +1 more source
Frontiers in Microbiology, 2018 Actinobacteria are an important source of commercial (bio)compounds for the biotechnological and pharmaceutical industry. They have also been successfully exploited in the search of novel biocatalysts. We set out to explore a recently identified actinomycete, Streptomyces leeuwenhoekii C34, isolated from a hyper-arid region, the Atacama desert, for ...
Gran-Scheuch, Alejandro +3 more
openaire +1 more source
Mining the chicken genome [PDF]
Genome Biology, 2002 The chicken EST repository gives access to a BLAST server dedicated to mining recently released sequence information from the chick large-scale expressed sequence tag (EST ...
openaire +1 more source
Bioinformatics' approaches to detect genetic variation in whole genome sequencing data [PDF]
, 2010 Current genetic marker repositories are not sufficient or even are completely lacking for most farm animals. However, genetic markers are essential for the development of a research tool facilitating discovery of genetic factors that contribute to ...
Kerstens, H.H.D.
core
Allele Mining for Genome Designing in Pearl Millet [PDF]
Sequencing of different crop genomes resulted into availablilty of massive sequence information in public databases. Now, it is essential to utilize this information to identify and isolate superior and novel alleles of agronomically important traits ...
Sankar, S M +9 more
core +1 more source
De novo sequence assembly of Albugo candida reveals a small genome relative to other biotrophic oomycetes [PDF]
, 2011 Background: Albugo candida is a biotrophic oomycete that parasitizes various species of Brassicaceae, causing a disease (white blister rust) with remarkable convergence in behaviour to unrelated rusts of basidiomycete fungi.
Beynon, E. +29 more
core +1 more source
Transposase‐Assisted Donor Tethering Boosts Large‐Fragment HDR in Plants
Advanced Science, EarlyView.A transposase‐assisted donor tethering strategy is developed to enhance homology‐directed repair in plants. By recruiting donor DNA to double‐strand breaks and synergizing with repair pathway reprogramming and transcription‐coupled donor design, this system markedly improves large‐fragment targeted insertion efficiency, providing a robust platform for ...
Sha Wei +8 more
wiley +1 more source