Results 101 to 110 of about 176,908 (324)

Unveiling combinatorial regulation through the combination of ChIP information and in silico cis-regulatory module detection [PDF]

, 2012
Computationally retrieving biologically relevant cis-regulatory modules (CRMs) is not straightforward. Because of the large number of candidates and the imperfection of the screening methods, many spurious CRMs are detected that are as high scoring as ...
Fierro, Ana Carolina, Guns, Tias, Marchal, Kathleen, Nijssen, Siegfried, Sun, Hong, Thorrez, Lieven   +5 more
core   +2 more sources

The Microbiota Shapes Central Nervous System Myelination in Early Life

Advanced Science, EarlyView.
Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch, Emily G. Knox, Daniel Soong, Thomaz F. S. Bastiaanssen, Kalevi Trontti, Gabriel S. S. Tofani, Sophia Ivaschuk, Michael K. Collins, Donia Arafa, Jatin Nagpal, Iiris Hovatta, David A. Lyons, Gerard Clarke, John F. Cryan   +13 more
wiley   +1 more source

Overview of Random Forest Methodology and Practical Guidance with Emphasis on Computational Biology and Bioinformatics [PDF]

, 2012
The Random Forest (RF) algorithm by Leo Breiman has become a standard data analysis tool in bioinformatics. It has shown excellent performance in settings where the number of variables is much larger than the number of observations, can cope with ...
Boulesteix, Anne-Laure, Janitza, Silke, Kruppa, Jochen, König, Inke R.   +3 more
core   +1 more source

Comparative genomics using data mining tools

Journal of Biosciences, 2002
We have analysed the genomes of representatives of three kingdoms of life, namely, archaea, eubacteria and eukaryota using data mining tools based on compositional analyses of the protein sequences. The representatives chosen in this analysis were Methanococcus jannaschii, Haemophilus influenzae and Saccharomyces cerevisiae.
Tannistha, Nandi, Chandrika, B-Rao, Srinivasan, Ramachandran   +2 more
openaire   +2 more sources

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

High-Throughput Mining of Novel Compounds from Known Microbes: A Boost to Natural Product Screening

Molecules
Advanced techniques can accelerate the pace of natural product discovery from microbes, which has been lagging behind the drug discovery era. Therefore, the present review article discusses the various interdisciplinary and cutting-edge techniques to ...
Surya Nandan Meena, Anna Wajs-Bonikowska, Savita Girawale, Md Imran, Preethi Poduwal, Kisan M. Kodam   +5 more
doaj   +1 more source

Pseudomonas cyclic lipopeptides suppress the rice blast fungus Magnaporthe oryzae by induced resistance and direct antagonism [PDF]

, 2019
Beneficial Pseudomonas spp. produce an array of antimicrobial secondary metabolites such as cyclic lipopeptides (CLPs). We investigated the capacity of CLP-producing Pseudomonas strains and their crude CLP extracts to control rice blast caused by ...
Batool, Humaira, De Mot, Rene, Höfte, Monica, Omoboye, Olumide Owolabi, Oni, Feyisara Eyiwumi, Yimer, Henok Zimene   +5 more
core   +1 more source

From Natural Discovery to AI‐Guided Design: A Curated Collection of Compact Enhancers for Crop Engineering

Advanced Science, EarlyView.
ABSTRACT Precise transgene‐free gene upregulation remains a challenge in crop biotechnology, as conventional enhancers often exceed CRISPR‐mediated knock‐in size constraints and face regulatory hurdles. Here we establish a foundational cross‐species resource of compact transcriptional enhancers developed via STEM‐seq, a high‐throughput screening ...
Qi Yao, Jin Gao, Keling Wang, Yufeng Liu, Peijin Han, Hong Pan, Xiaofeng Yang, Qianlan Yin, Dating Zhong, Lu Ye, Qi Deng, Lingling Gao, Xiaoyu Tu, Dequan Wang, Yuming Lu   +14 more
wiley   +1 more source

Genome-inspired molecular identification in organic matter via Raman spectroscopy

, 2016
Rapid, non-destructive characterization of molecular level chemistry for organic matter (OM) is experimentally challenging. Raman spectroscopy is one of the most widely used techniques for non-destructive chemical characterization, although it currently ...
Bryndzia, L. Taras, Ferralis, Nicola, Grossman, Jeffrey C., Liu, Yun   +3 more
core   +1 more source

Mining the genome for lipid genes

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014
Mining of the genome for lipid genes has since the early 1970s helped to shape our understanding of how triglycerides are packaged (in chylomicrons), repackaged (in very low density lipoproteins; VLDL), and hydrolyzed, and also how remnant and low-density lipoproteins (LDL) are cleared from the circulation.
Kuivenhoven, Jan Albert, Hegele, Robert A.   +1 more
openaire   +2 more sources