Results 111 to 120 of about 1,940,445 (217)
Comparative genomics using data mining tools
Journal of Biosciences, 2002 We have analysed the genomes of representatives of three kingdoms of life, namely, archaea, eubacteria and eukaryota using data mining tools based on compositional analyses of the protein sequences. The representatives chosen in this analysis were Methanococcus jannaschii, Haemophilus influenzae and Saccharomyces cerevisiae.
Tannistha, Nandi +2 more
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High-Throughput Mining of Novel Compounds from Known Microbes: A Boost to Natural Product Screening
MoleculesAdvanced techniques can accelerate the pace of natural product discovery from microbes, which has been lagging behind the drug discovery era. Therefore, the present review article discusses the various interdisciplinary and cutting-edge techniques to ...
Surya Nandan Meena +5 more
doaj +1 more source
Fully Online Grammar Compression in Constant Space
, 2014 We present novel variants of fully online LCA (FOLCA), a fully online grammar compression that builds a straight line program (SLP) and directly encodes it into a succinct representation in an online manner. FOLCA enables a direct encoding of an SLP into
Maruyama, Shirou, Tabei, Yasuo
core +1 more source
Mining the genome for lipid genes
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014 Mining of the genome for lipid genes has since the early 1970s helped to shape our understanding of how triglycerides are packaged (in chylomicrons), repackaged (in very low density lipoproteins; VLDL), and hydrolyzed, and also how remnant and low-density lipoproteins (LDL) are cleared from the circulation.
Kuivenhoven, Jan Albert +1 more
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Genome Mining of Fungal Unique Trichodiene Synthase-like Sesquiterpene Synthases
Journal of FungiSesquiterpenoids served as an important source for natural product drug discovery. Although genome mining approaches have revealed numerous novel sesquiterpenoids and biosynthetic enzymes, the comprehensive landscape of fungal sesquiterpene synthases ...
Zhanren Cong +8 more
doaj +1 more source
The rice genome annotation project: an updated database for mining the rice genome
Nucleic Acids ResearchRice (Oryza sativa L.) is a major cereal crop that provides calories across the world. With a small genome, rice has been used extensively as a model for genetic and genomic studies in the Poaceae.
John P. Hamilton, Chenxin Li, C. Buell
semanticscholar +1 more source
The Metabolic Potential of the Human Lung Microbiome
MicroorganismsThe human lung microbiome remains largely underexplored, despite its potential implications in the pharmacokinetics of inhaled drugs and its involvement in lung diseases.
Florian Semmler +3 more
doaj +1 more source
Mining the Genome for Therapeutic Targets [PDF]
Diabetes, 2017 Current pharmacological options for type 2 diabetes do not cure the disease. Despite the availability of multiple drug classes that modulate glycemia effectively and minimize long-term complications, these agents do not reverse pathogenesis, and in practice they are not selected to correct the molecular profile specific to the patient.
openaire +2 more sources
Frontiers in Microbiology, 2018 Actinobacteria are an important source of commercial (bio)compounds for the biotechnological and pharmaceutical industry. They have also been successfully exploited in the search of novel biocatalysts. We set out to explore a recently identified actinomycete, Streptomyces leeuwenhoekii C34, isolated from a hyper-arid region, the Atacama desert, for ...
Gran-Scheuch, Alejandro +3 more
openaire +1 more source
Molecules, 2016 Genome mining is an effective tool used to discover novel natural products from actinomycetes. Genome sequence analysis of Streptomyces sp. FJS31-2 revealed the presence of one putative type II polyketide gene cluster (ABX), which may correspond to type ...
Yuhong Lü +10 more
doaj +1 more source