Results 111 to 120 of about 176,908 (324)
Development of Dimethylsulfonium Probes for Broad Profiling of Methyllysine Reader Proteins
Advanced Science, EarlyView.Development of oligoglycine‐based dimethylsulfonium probes for unbiased crosslinking to methyllysine readers. The general probe facilitates profiling of site‐specific methyllysine readers, evaluation of selectivity and activity of reader inhibitors, and global profiling of methyllysine readers.
Jinyu Yang +3 more
wiley +1 more source
Genome Mining of Fungal Unique Trichodiene Synthase-like Sesquiterpene Synthases
Journal of FungiSesquiterpenoids served as an important source for natural product drug discovery. Although genome mining approaches have revealed numerous novel sesquiterpenoids and biosynthetic enzymes, the comprehensive landscape of fungal sesquiterpene synthases ...
Zhanren Cong +8 more
doaj +1 more source
CACLENS: A Multitask Deep Learning System for Enzyme Discovery
Advanced Science, EarlyView.CACLENS, a multimodal and multi‐task deep learning framework integrating cross‐attention, contrastive learning, and customized gate control, enables reaction type classification, EC number prediction, and reaction feasibility assessment. CACLENS accelerates functional enzyme discovery and identifies efficient Zearalenone (ZEN)‐degrading enzymes.
Xilong Yi +5 more
wiley +1 more source
The Metabolic Potential of the Human Lung Microbiome
MicroorganismsThe human lung microbiome remains largely underexplored, despite its potential implications in the pharmacokinetics of inhaled drugs and its involvement in lung diseases.
Florian Semmler +3 more
doaj +1 more source
Genome mining for new enediyne antibiotics. [PDF]
Curr Opin Chem BiolEnediyne antibiotics epitomize nature's chemical creativity. They contain intricate molecular architectures that are coupled with potent biological activities involving double-stranded DNA scission. The recent explosion in microbial genome sequences has revealed a large reservoir of novel enediynes. However, while hundreds of enediyne biosynthetic gene
Han EJ, Seyedsayamdost MR.
europepmc +3 more sources
Advanced Science, EarlyView.Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang +7 more
wiley +1 more source
Mining the Genome for Therapeutic Targets [PDF]
Diabetes, 2017 Current pharmacological options for type 2 diabetes do not cure the disease. Despite the availability of multiple drug classes that modulate glycemia effectively and minimize long-term complications, these agents do not reverse pathogenesis, and in practice they are not selected to correct the molecular profile specific to the patient.
openaire +2 more sources
Advanced Science, EarlyView.This study identifies a conserved CsdA‐LaeB hub in Aspergillus fumigatus that regulates secondary metabolite fumiquinazoline C (FqC). Disrupting this hub enhances FqC production and virulence, shedding new light on the post‐transcriptional regulatory logic linking secondary metabolism to pathogenicity and offering alternative strategies for diagnostic ...
Zili Song +14 more
wiley +1 more source
Fully Online Grammar Compression in Constant Space
, 2014 We present novel variants of fully online LCA (FOLCA), a fully online grammar compression that builds a straight line program (SLP) and directly encodes it into a succinct representation in an online manner. FOLCA enables a direct encoding of an SLP into
Maruyama, Shirou, Tabei, Yasuo
core +1 more source