Results 141 to 150 of about 105,282 (228)

Homoterpene Biosynthesis in Fungi

Angewandte Chemie International Edition, EarlyView.
The first homoterpene biosynthetic pathway in the fungal kingdom is reported. A methyltransferase–terpene cyclase pair produces a unique heptamethyl bicyclo[3.3.1]nonane homoterpene via presodorifen, demonstrating that homoterpene biosynthesis via the addition of a C1 unit to terpene diphosphate precursors prior to scaffold formation extends beyond the
Lin Zhou, Tatjana Reuter, Kiara Schumann, Markus Mayer, Dominik Matthias Hanauska, Lena Barra   +5 more
wiley   +1 more source

Identifying Predictive Biomarkers of Response in Patients With Rheumatoid Arthritis Treated With Adalimumab Using Machine Learning Analysis of Whole‐Blood Transcriptomics Data

Arthritis &Rheumatology, EarlyView.
Objective Tumornecrosis factor inhibitors (TNFi) have significantly improved rheumatoid arthritis (RA) management, yet variability in patient response remains a substantial challenge, with approximately 40% of patients discontinuing TNFi due to nonresponse or adverse effects.
Chuan Fu Yap, Nisha Nair, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme Hyrich, Guillermo Barturen, María Riva‐Torrubia, Marta Gut, Ivo Gut, Marta E. Alarcón Riquelme, Anne Barton, Darren Plant   +12 more
wiley   +1 more source

Flow Cytometry: Advances, Challenges and Trends

BioEssays, EarlyView.
Recent advances in flow cytometry span hardware, data processing, and AI‐driven analytics. Emerging modalitiesincluding spectral, imaging, mass, and nano/EV cytometryenable higher‐parameter and small‐particle detection. Integrated machine learning drives a shift from manual gating toward automated multi‐omics workflows.
J. Paul Robinson, Grzegorz B. Gmyrek, Bartek Rajwa   +2 more
wiley   +1 more source

Artificial intelligence‐assisted design, synthesis and analysis of smart biomaterials

BMEMat, EarlyView.
Smart biomaterials are rapidly emerging as tools for tissue engineering, and artificial intelligence has played essential roles in biomaterial studies. By bridging the literature gap in AI‐based design, synthesis and analysis of smart biomaterials, the current review shares perspectives on how biomaterial scientists can practically incorporate AI for ...
Pengfei Jiang, Yefei Dai, Yujun Hou, Joshua Stein, Shichen Steven Lin, Chaochen Zhou, Yannan Hou, Rongrong Zhu, Ki‐Bum Lee, Letao Yang   +9 more
wiley   +1 more source

Genome Sequencing and Characterization of Bacillus velezensis N23 as Biocontrol Agent against Plant Pathogens

Microorganisms
The overuse of chemical fungicides against fungal pathogens adversely affects soil and plant health, resulting in environmental problems and food safety.
Panlei Yang, Qingchao Zeng, Wenxiao Jiang, Luotao Wang, Jie Zhang, Zhenshuo Wang, Qi Wang, Yan Li   +7 more
doaj   +1 more source

Common but Least Noticed: Diversity of the Mangrove Fern Acrostichum aureum in Hainan Island, China

Biological Diversity, EarlyView.
Acrostichum aureum across nine coastal sites in Hainan Island was examined using morphological, cytometric, and genomic approaches. Three priority conservation areas are proposed to preserve extant genetic diversity and maintain habitat connectivity. ABSTRACT Acrostichum aureum across nine coastal sites in Hainan Island was examined using morphological,
Bingyan Guo, Rui Guo, Hongjuan Zhu, Changwang Ma, Dan He, Xialan Cheng, Yougen Wu, Ya Liu, Jing Yu, Dongmei Yang   +9 more
wiley   +1 more source

Manganese‐Induced Production of Antioxidant Polyene Steroids in the Extremophile Fungus Talaromyces fuscoviridis Isolated From Copper‐Mine Soil

Chemistry &Biodiversity, EarlyView.
ABSTRACT The fungus Talaromyces fuscoviridis was isolated from soil collected in a copper‐mine tailings basin in Pará State, Brazil, an extreme environment that can induce the production of bioactive secondary metabolites. Extracts and fractions obtained after cultivation were analyzed by liquid chromatography coupled to high‐resolution mass ...
Mauricio Augusto Pinto Moreno da Silva Alves, Alef dos Santos, Eduardo Jorge Pilau, Pedro Henrique de Oliveira Santiago, Javier Alcides Ellena, Marilene Nunes Oliveira, Edson Rodrigues Filho   +6 more
wiley   +1 more source

Biological Conversion of Formate to Organic Compounds: Toward a Sustainable Formate Bioeconomy

Carbon Energy, EarlyView.
Formate bioconversion plays a crucial role in achieving renewable resource utilization and sustainable development. To tap its full potential, it is important to identify the most appropriate microbial hosts for incorporating formate into building blocks, design the most promising metabolic pathways for transmitting formate into central carbon ...
Jinyi Qian, Tiantian Chai, Chunlei Zhao, Xiulai Chen   +3 more
wiley   +1 more source

Selective Modification of the Product Profile of Biocatalytic Hydrolyzed PET via Product‐Specific Medium Engineering

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
The product profile of enzymatically hydrolyzed PET can be modified by medium engineering and thereby adapted to a desired product. TPA, MHET or BHET can be forced as the predominant product using a basic pH (blue), 25 % ethylene glycol (EG) and IsPETasewt (green) or ≥25 % EG and LCCICCG (pink), respectively.
Tobias Heinks, Katrin Hofmann, Simon Last, Igor Gamm, Luise Blach, Ren Wei, Uwe T. Bornscheuer, Christof Hamel, Jan von Langermann   +8 more
wiley   +1 more source

Toward the Bioremediation of Nylon Waste Materials: Genome Mining Leads to the Identification of a Thermostable Laurolactamase From Thermopolyspora flexuosa

ChemSusChem, EarlyView.
To enhance nylon waste remediation, genome mining was used to identify a thermostable laurolactam hydrolase from Thermopolyspora flexuosa with activity against an important cyclic nylon derivative. Substrate scope analysis and structural modeling revealed key features controlling enzyme‐substrate compatibility, providing a promising foundation for ...
Maria E. Cleveland, Amir R. Bunyat‐zada, Esther R. Hoffman, Graeme W. Howe   +3 more
wiley   +1 more source