Results 171 to 180 of about 105,282 (228)

Bottom–up and top–down diversification: asymmetric processes over space and time

Oikos, EarlyView.
Coevolution in trophic interactions is often considered as a major factor underlying diversification in interacting species. Most focus hitherto has however been on bottom–up processes where host‐associated differentiation drives diversification, and less on top–down processes through enemy‐associated differentiation.
Peter A. Hambäck, Niklas Janz
wiley   +1 more source

Comprehensive Insights into Natural Bioactive Compounds: From Chemical Diversity and Mechanisms to Biotechnological Innovations and Applications

ChemistryOpen, EarlyView.
Natural products derived from plants, animals, fungi, bacteria, and minerals contain diverse bioactive classes such as alkaloids, flavonoids, terpenoids, saponins, tannins, and phenolics. These natural products work through different mechanisms, including ROS inhibition, NF‐κB suppression, and cytokine regulation, and exhibit wide applications across ...
Sajid Ali, Atif Ali Khan Khalil, Muhammad Saeed Akhtar, Adnan Amin, Wajid Zaman   +4 more
wiley   +1 more source

Global Delivery of Foetal Sequencing: Do We Need Some Standardisation?

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective The development of sequencing technologies has resulted in rapid expansion in the testing available for foetuses with structural anomalies to diagnose monogenic disorders. To understand the variability in how foetal sequencing services are delivered, we developed a survey that focussed on the scope of testing, any parallel testing ...
Natalie J. Chandler, Zandra C. Deans
wiley   +1 more source

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

The Cinderella tree, Quillaja saponaria – A soap story

PLANTS, PEOPLE, PLANET, EarlyView.
Our current understanding of plants has been shaped by the entwining of different cultures. The Chilean soapbark tree, traditionally valued as a source of natural soap, was shown by serendipitous research in France in the 1900s to produce compounds that can boost the immune response to vaccines.
Anne Osbourn
wiley   +1 more source

Rhizosphere microbial detoxification and phosphorus solubilization drive ecological remediation of Pb–Zn contaminated soils

PLANTS, PEOPLE, PLANET, EarlyView.
Heavy metal contamination of soils poses a serious threat to ecosystem health and food security worldwide. This study investigated how native plants, such as Artemisia annua and Buddleja davidii, interact with soil microbes in Pb–Zn waste slag areas. We found that these plants stimulate microbes, which improve phosphorus availability and reduce metal ...
Caili Sun, Yajuan Yao, Yongwei Liu, Xiaoyu Lu   +3 more
wiley   +1 more source

Comparative lipidomic and proteomic analysis reveals species‐specific differences in midgut composition and insecticide absorption between Apis mellifera and Bombus terrestris

Pest Management Science, EarlyView.
Lipidomic and proteomic analysis revealed large‐scale differences in the midgut composition of the honeybee Apis mellifera and the buff‐tailed bumblebee Bombus terrestris. These differences correlated to increased insecticide absorption in the bumblebee when using an ex vivo Ussing chamber and subsequently in vivo feeding assay (created in Biorender ...
Emmanouil Kokkas, Joseph Hawkins, Lauraine Swindale, Aniko Kende, John Sinclair, Jacob M Riveron, Helen Thompson, Adam Pym   +7 more
wiley   +1 more source

Stimuli‐responsive systems: A focus on controlled drug delivery for posterior segment ocular disease

Responsive Materials, EarlyView.
This review highlights recent advances in stimuli‐responsive drug delivery for posterior segment diseases, focusing on mechanisms and potential. It also explores mechanically interlocked molecules and bioorthogonal reactions as novel approaches. Challenges and future perspectives are discussed, aiming to bridge the gap between research and clinical ...
Chengzhi Zhang, Jiayi Hou, Yameng Zhao, Yiwen Wang, Kexin Wang, Siyu Li, Yange Wang, Jiehao Zhang, Shenao Ding, Chenxu Zhang, Zongming Song, Ye Tao   +11 more
wiley   +1 more source

BMDx2: A Tool for Integrating Toxicogenomics‐Based Dose‐Dependency Analysis and AOP‐Based Mechanistic Insights

Small Methods, EarlyView.
BMDx2 is an open‐source tool that integrates benchmark‐dose modeling with Adverse Outcome Pathway (AOP) enrichment to convert omics data into quantitative, mechanistic evidence. Case studies on rigid multi‐walled carbon nanotubes and bleomycin demonstrate its ability to reveal fibrosis‐related mechanisms, supporting both mechanistic discovery and ...
Angela Serra, Michele Fratello, Giorgia Migliaccio, Emanuele Di Lieto, Marcella Torres Maia, Laura Aliisa Saarimäki, Alisa Pavel, Alexandra Schaffert, Andreas Tsoumanis, Antreas Afantitis, Jack Morikka, Giusy del Giudice, Dario Greco   +12 more
wiley   +1 more source

Neural mechanisms and clinical features of anti‐influenza drug‐related psychiatric adverse events

VIEW, EarlyView.
Anti–influenza drugs, while essential, have been increasingly associated with psychiatric adverse events (pAEs). Our study systematically investigated these pAEs by utilizing large pharmacovigilance databases and animal models, thereby revealing key clinical features and underlying neural mechanisms.
Anqi Lin, Tong Jiang, Chaofan Fan, Yihan Gao, Dan Shan, Qingxi Zhang, Kun Huang, Peng Luo, Shuofeng Yuan, Xin Chen   +9 more
wiley   +1 more source