Results 171 to 180 of about 1,743,586 (380)
Microbial Biotechnology, 2019 For over seven decades, bacteria served as a valuable source of bioactive natural products some of which were eventually developed into drugs to treat infections, cancer and immune system‐related diseases.
O. Sekurova, Olha Schneider, S. Zotchev
semanticscholar +1 more source
Construction of Large‐Scale Bioengineered Hair Germs and In Vivo Transplantation
Advanced Science, Volume 12, Issue 16, April 24, 2025.Here, a novel bioengineered hair germ (BHG) system is developed using thermodynamically incompatible mucopolysaccharides for efficient hair follicle regeneration. The BHG microspheres, produced via microfluidic technology, encapsulate Wnt3a for sustained release, enhancing mesenchymal stem cell differentiation and activating key regeneration pathways ...
Yangpeng Chen +8 more
wiley +1 more source
yMGV: a database for visualization and data mining of published genome-wide yeast expression data [PDF]
, 2001 Philippe Marc
openalex +1 more source
Redesigning pattern mining algorithms for supercomputers [PDF]
arXiv, 2015 Upcoming many core processors are expected to employ a distributed memory architecture similar to currently available supercomputers, but parallel pattern mining algorithms amenable to the architecture are not comprehensively studied. We present a novel closed pattern mining algorithm with a well-engineered communication protocol, and generalize it to ...
arxiv
An Engineered PfAgo with Wide Catalytic Temperature Range and Substrate Spectrum
Advanced Science, EarlyView.This work presents a strategy for engineering thermophilic Ago proteins to obtain wide catalytic temperature range and broad substrate spectrum. This strategy is applied to engineer PfAgo and TtdAgo, and the biochemical properties of the engineered PfAgo are systematically characterized. The study further elucidates the structural differences involved.
Longyu Wang +11 more
wiley +1 more source
Autonomous Self‐Evolving Research on Biomedical Data: The DREAM Paradigm
Advanced Science, EarlyView.DREAM is a fully autonomous, self‐evolving biomedical research system capable of independently formulating scientific questions, performing analyses, and making new discoveries without human intervention. Validated in biomedical studies, DREAM significantly outperforms human scientists in research efficiency, accelerating scientific discovery and ...
Luojia Deng +3 more
wiley +1 more source
Data-Mining Approaches Reveal Hidden Families of Proteases in the Genome of Malaria Parasite [PDF]
, 2003 Yimin Wu +3 more
openalex +1 more source
, 2014 Pathogenic bacteria present a large disease burden on human health. Control of these pathogens is hampered by rampant lateral gene transfer, whereby pathogenic strains may acquire genes conferring resistance to common antibiotics. Here we introduce tools
A. Holzinger +13 more
core +1 more source
Mining Functional Modules by Multiview-NMF of Phenome-Genome Association [PDF]
arXiv, 2017 Background: Mining gene modules from genomic data is an important step to detect gene members of pathways or other relations such as protein-protein interactions. In this work, we explore the plausibility of detecting gene modules by factorizing gene-phenotype associations from a phenotype ontology rather than the conventionally used gene expression ...
arxiv
Advanced Science, EarlyView.Salt stress endangers coastal cereal crops, requiring resilient crop solutions. This study employs machine learning (KANMB) to analyze multi‐omics data from halophyte Spartina alterniflora, revealing 226 salt‐stress biomarkers and linking them to tolerance pathways. The MYB gene SaMYB35 regulates flavonoid biosynthesis under salinity.
Shoukun Chen +7 more
wiley +1 more source