Results 181 to 190 of about 1,940,445 (217)

Decontamination of DNA sequences from a Streptomyces genome for optimal genome mining. [PDF]

Braz J Microbiol
de Oliveira RVF, Garrido LM, Padilla G.
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Development of a bioassay guided genome mining approach for antifungal natural product discovery from pseudomonads

Lund G, Mosquito S, Withall DM, Caulfield J, Hughes D, Clark IM, Rudd J, Mauchline TH.   +7 more
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Discovery of a Unique Flavonoid Biosynthesis Mechanism in Fungi by Genome Mining.

Angewandte Chemie, 2023
Flavonoids are important plant natural products with variable structures and bioactivities. All known plant flavonoids are generated under the catalysis of type III PKS followed by chalcone isomerase (CHI) and flavone synthase (FNS).
Wei Zhang, Xuan Zhang, Dandan Feng, Yajing Liang, Zhenying Wu, Siyu Du, Y. Zhou, Ce Geng, P. Men, C. Fu, Xuenian Huang, Xuefeng Lu   +11 more
semanticscholar   +1 more source

Mining the Pseudomonas Genome

2014
Pseudomonas species were targeted early for genomic studies since they were noted for their diverse metabolic capacity, ability to inhabit a wide range of environments and hosts, and include notable human and agriculturally relevant pathogens. As more genomes are sequenced, the power of genome-scale analyses are increasing and a wide range of analyses ...
Geoffrey L, Winsor, Fiona S L, Brinkman
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MINING THE GENOME

Chemical & Engineering News Archive, 2002
Having tackled the human genome, Celera's Gene Myers is now advancing on proteins and drug development. This article discusses Myers' work on developing computational biology for the human genome project. The further development of computational biology for the pharmaceutical industry is also discussed.
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Expanding the Chemical Diversity of Fasamycin Via Genome Mining and Biocatalysis.

Journal of Natural Products, 2022
Genome mining and biocatalytic modification of chemical structures are critical methods to develop new antibiotics. In this study, eight new fasamycins (3, 4, 6, and 8-12) along with five known analogues (1, 2, 5, 7, and 13) were obtained by the ...
Kai Jiang, Xiaoli Yan, Z. Deng, Chun Lei, X. Qu   +4 more
semanticscholar   +1 more source

Mining microsatellites in eukaryotic genomes

Trends in Biotechnology, 2007
During recent decades, microsatellites have become the most popular source of genetic markers. More recently, the availability of enormous sequence data for a large number of eukaryotic genomes has accelerated research aimed at understanding the origin and functions of microsatellites and searching for new applications.
Prakash C, Sharma, Atul, Grover, Günter, Kahl   +2 more
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Genome mining with hypothetical proteins.

Methods in Enzymology
Grace E. Kenney
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A Combination of Genome Mining with an OSMAC Approach Facilitates the Discovery of and Contributions to the Biosynthesis of Melleolides from the Basidiomycete Armillaria tabescens.

Journal of Agricultural and Food Chemistry, 2022
Genome mining revealed that the genomes of basidiomycetes may include a considerable number of biosynthetic gene clusters (BGCs), yet numerous clusters remain unidentified.
Tao Zhang, Guowei Cai, Xiaoting Rong, Yuquan Wang, Kaikai Gong, Wancang Liu, Lü-ya Wang, Xu Pang, Liyan Yu   +8 more
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Genome Mining Reveals a Multiproduct Sesterterpenoid Biosynthetic Gene Cluster in Aspergillus ustus.

Organic Letters, 2021
Genome mining of Aspergillus ustus 094102 enabled the discovery of a multiproduct bifunctional terpene synthase (BTS), AuAS. Heterologous expression of AuAS led to the discovery of five new sesterterpenes, and coexpression of the upstream CYP450 ...
Jingjing Guo, You-sheng Cai, Fangcai Cheng, Chenjie Yang, Wenqi Zhang, Wulin Yu, Jingjing Yan, Z. Deng, K. Hong   +8 more
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