Results 11 to 20 of about 105,282 (228)
Journal of Fungi, 2023 Fungi represents a rich repository of taxonomically restricted, yet chemically diverse, secondary metabolites that are synthesised via specific metabolic pathways.
Suhad A. A. Al-Salihi, Fabrizio Alberti
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Mining the draft human genome [PDF]
Nature, 2001 Now that the draft human genome sequence is available, everyone wants to be able to use it. However, we have perhaps become complacent about our ability to turn new genomes into lists of genes. The higher volume of data associated with a larger genome is accompanied by a much greater increase in complexity.
Birney, E +3 more
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Genome Mining as New Challenge in Natural Products Discovery
Marine Drugs, 2020 Drug discovery is based on bioactivity screening of natural sources, traditionally represented by bacteria fungi and plants. Bioactive natural products and their secondary metabolites have represented the main source for new therapeutic agents, used as ...
Luisa Albarano +3 more
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Microorganisms, 2021 A promising keratin-degrading strain from the genus Chryseobacterium (Chryseobacterium sp. KMC2) was investigated using comparative genomic tools against three publicly available reference genomes to reveal the keratinolytic potential for biosynthesis of
Dingrong Kang +4 more
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Underexplored bacteria as reservoirs of novel antimicrobial lipopeptides
Frontiers in Chemistry, 2022 Natural products derived from microorganisms play a prominent role in drug discovery as potential anti-infective agents. Over the past few decades, lipopeptides produced by particularly Bacillus, Pseudomonas, Streptomyces, Paenibacillus, and ...
Tanya Clements-Decker +3 more
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Diversity, 2022 A yellow bacterium from marine agar, strain WHA3T, was isolated from the mantel of the Pacific oysters Crassostrea gigas in the Wilhelmshaven Sea in northern Germany.
Hani Pira +4 more
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Mining for viral fragments in methylation enriched sequencing data [PDF]
, 2015 Most next generation sequencing experiments generate more data than is required for the experimental set up. For example, methyl-CpG binding domain (MBD) affinity purification based sequencing is often used for DNA-methylation profiling, but up to 30% of
Ed eSchuuring +7 more
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Reference Based Genome Compression [PDF]
, 2012 DNA sequencing technology has advanced to a point where storage is becoming the central bottleneck in the acquisition and mining of more data. Large amounts of data are vital for genomics research, and generic compression tools, while viable, cannot ...
Chern, Bobbie +5 more
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Strain prioritization and genome mining for enediyne natural products [PDF]
, 2016 The enediyne family of natural products has had a profound impact on modern chemistry, biology, and medicine, and yet only 11 enediynes have been structurally characterized to date.
Ben Shen +18 more
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Marine Drugs, 2022 Culturing ascidian-derived fungus Amphichorda felina SYSU-MS7908 under standard laboratory conditions mainly yielded meroterpenoid, and nonribosomal peptide-type natural products.
Siwen Yuan +8 more
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