Results 211 to 220 of about 105,282 (228)
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Mining microsatellites in eukaryotic genomes
Trends in Biotechnology, 2007During recent decades, microsatellites have become the most popular source of genetic markers. More recently, the availability of enormous sequence data for a large number of eukaryotic genomes has accelerated research aimed at understanding the origin and functions of microsatellites and searching for new applications.
Prakash C, Sharma +2 more
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Nature, 2000
The level of iron in our blood is controlled by tightly regulating the amount of iron that is absorbed through the gut wall. This is a two-step process — iron is taken up in cells called enterocytes that line the gut, and then exported from the enterocytes into the bloodstream.
Jerry Kaplan, James P. Kushner
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The level of iron in our blood is controlled by tightly regulating the amount of iron that is absorbed through the gut wall. This is a two-step process — iron is taken up in cells called enterocytes that line the gut, and then exported from the enterocytes into the bloodstream.
Jerry Kaplan, James P. Kushner
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Mining proteases in the genome databases
Essays in Biochemistry, 2002Protease data mining can take advantage both of the many specialist, Web-available databases that cover the genetic, protein and nucleic acid sequence information that is specific to a variety of organisms, and of a flexible, but defined, classification system. However, precomputed data, such as gene predictions, should be used with care.
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Mining the Mammalian Genome for Artiodactyl Systematics
Systematic Biology, 2001A total of 7,806 nucleotide positions derived from one mitochondrial and eight nuclear DNA segments were used to provide a robust phylogeny for members of the order Artiodactyla. Twenty-four artiodactyl and two cetacean species were included, and the horse (order Perissodactyla) was used as the outgroup.
C A, Matthee +3 more
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Mining genomes and ‘metagenomes’ for novel catalysts
Current Opinion in Biotechnology, 2005Advances in the field of genomics and 'metagenomics' have dramatically revised our view of microbial biodiversity and its potential for biotechnological applications. Considering the estimation that >99% of microorganisms in most environments are not amenable to culturing, very little is known about their genomes, genes and encoded enzymatic activities.
Manuel, Ferrer +2 more
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Science, 1999
SCIENCE AND BUSINESSPartly because of its early association with The Institute for Genomic Research, a company started by researchers who had devised an efficient way of finding genes, Human Genome Sciences Inc. of Rockville, Maryland, has a leg up on other biotech companies in current efforts to use modern genomics to find and develop new protein ...
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SCIENCE AND BUSINESSPartly because of its early association with The Institute for Genomic Research, a company started by researchers who had devised an efficient way of finding genes, Human Genome Sciences Inc. of Rockville, Maryland, has a leg up on other biotech companies in current efforts to use modern genomics to find and develop new protein ...
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Antimicrobials, drug discovery, and genome mining
Applied Microbiology and Biotechnology, 2012Over the years, antibiotics have provided an effective treatment for a number of microbial diseases. However recently, there has been an increase in resistant microorganisms that have adapted to our current antibiotics. One of the most dangerous pathogens is methicillin-resistant Staphylococcus aureus (MRSA).
R J, Scheffler +4 more
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Using Proteomics to Mine Genome Sequences
Journal of Proteome Research, 2004We present a method for mining unannotated or annotated genome sequences with proteomic data to identify open reading frames. The region of a genome coding for a protein sequence is identified by using information from the analysis of proteins and peptides with MALDI-TOF mass spectrometry.
Jonathan W, Arthur, Marc R, Wilkins
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Repeats in genomic DNA: mining and meaning
Current Opinion in Structural Biology, 1998For hundreds of millions of years, perhaps from the very beginning of their evolutionary history, eukaryotic cells have been habitats and junkyards for countless generations of transposable elements, preserved in repetitive DNA sequences. Analysis of these sequences, combined with experimental research, reveals a history of complex 'intracellular ...
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Mining bacterial genomes for antimicrobial targets
Molecular Medicine Today, 2000The elucidation of whole-genome sequences is expected to have a revolutionary impact on the discovery of novel medicines. With the availability of complete genome sequences of more than 30 different species, the field of antimicrobial drug discovery has the opportunity to access a remarkable diversity of genomic information. In this review, I summarize
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