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2006
The genomic data mine represents a fundamental shift from genetics to genomics, essentially from the study of one gene at a time to the study of entire genetic metabolic networks and whole genomes. Experimental laboratory data are deposited into large public repositories and a wealth of computational data mining algorithms and tools are applied to mine
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The genomic data mine represents a fundamental shift from genetics to genomics, essentially from the study of one gene at a time to the study of entire genetic metabolic networks and whole genomes. Experimental laboratory data are deposited into large public repositories and a wealth of computational data mining algorithms and tools are applied to mine
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Genome mining for new enediyne antibiotics
Current Opinion in Chemical BiologyEnediyne antibiotics epitomize nature's chemical creativity. They contain intricate molecular architectures that are coupled with potent biological activities involving double-stranded DNA scission. The recent explosion in microbial genome sequences has revealed a large reservoir of novel enediynes. However, while hundreds of enediyne biosynthetic gene
Esther J. Han +1 more
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Genome mining and prospects for antibiotic discovery
Current Opinion in Microbiology, 2019Natural products are a rich source of bioactive compounds that have been used successfully in the areas of human health from infectious disease to cancer; however, traditional fermentation-based screening has provided diminishing returns over the last 20-30 years.
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Bovine Genome Database: Tools for Mining the Bos taurus Genome
2018The Bovine Genome Database (BGD; http://bovinegenome.org ) is a web-accessible resource that supports bovine genomics research by providing genome annotation and data mining tools. BovineMine is a tool within BGD that integrates BGD data, including the genome, genes, precomputed gene expression levels and variant consequences, with external data ...
Darren E, Hagen +4 more
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Data mining in genomics and proteomics
Artificial Intelligence in Medicine, 2004openaire +1 more source