Results 61 to 70 of about 1,940,445 (217)

How to Completely Squeeze a Fungus—Advanced Genome Mining Tools for Novel Bioactive Substances

Pharmaceutics, 2022
Fungal species have the capability of producing an overwhelming diversity of bioactive substances that can have beneficial but also detrimental effects on human health.
Andreas Schüller, Lena Studt-Reinhold, Joseph Strauss   +2 more
doaj   +1 more source

De Novo Assembly of Nucleotide Sequences in a Compressed Feature Space [PDF]

, 2017
Sequencing technologies allow for an in-depth analysis of biological species but the size of the generated datasets introduce a number of analytical challenges.
Robertson, David L., Tapinos, Avraam
core   +1 more source

Mining Unique-m Substrings from Genomes [PDF]

Journal of Proteomics & Bioinformatics, 2010
Unique substrings in genomes may indicate high level of specificity which is crucial and fundamental to many genetics studies, such as PCR, microarray hybridization, Southern and Northern blotting, RNA interference (RNAi), and genome (re)sequencing. However, being unique sequence in the genome alone is not adequate to guaranty high specificity.
Ye, Kai, Jia, Zhenyu, Wang, Yipeng, Flicek, Paul, Apweiler, Rolf   +4 more
openaire   +2 more sources

Web2.0 paves new ways for collaborative and exploratory analysis of Chemical Compounds in Spectrometry Data

Journal of Integrative Bioinformatics, 2011
In nowadays life science projects, sharing data and data interpretation is becoming increasingly important. This considerably calls for novel information technology approaches, which enable the integration of expert knowledge from different disciplines ...
Loyek Christian, Bunkowski Alexander, Vautz Wolfgang, Nattkemper Tim W.   +3 more
doaj   +1 more source

Mining Natural Product Biosynthesis in Eukaryotic Algae

Marine Drugs, 2020
Eukaryotic algae are an extremely diverse category of photosynthetic organisms and some species produce highly potent bioactive compounds poisonous to humans or other animals, most notably observed during harmful algal blooms.
Ellis O’Neill
doaj   +1 more source

Gene Loss and Horizontal Gene Transfer Contributed to the Genome Evolution of the Extreme Acidophile “Ferrovum” [PDF]

, 2016
Indexación: Web of Science. Scopus.Acid mine drainage (AMD), associated with active and abandoned mining sites, is a habitat for acidophilic microorganisms that gain energy from the oxidation of reduced sulfur compounds and ferrous iron and that thrive ...
Daniel, Rolf, González, Carolina, Holmes, David S., Mühling, Martin, Poehlein, Anja, Schlömann, Michael, Tischler, Judith S., Ullrich, Sophie R.   +7 more
core   +2 more sources

Genome-Guided Investigation Provides New Insights into Secondary Metabolites of Streptomyces parvulus SX6 from Aegiceras corniculatum

Polish Journal of Microbiology, 2022
Whole-genome sequencing and genome mining are recently considered an efficient approach to shine more light on the underlying secondary metabolites of Streptomyces.
Quach Ngoc Tung, Nguyen Vu Thi Hanh, Bui Thi Lien, Pham Anh Tuan, An Nguyen Thi Thu, Xuan Le Thi Thanh, Thuy Ta Thi Thu, Dudhagara Pravin, Phi Quyet-Tien   +8 more
doaj   +1 more source

Targeted Genome Mining Reveals the Biosynthetic Gene Clusters of Natural Product CYP51 Inhibitors.

Journal of the American Chemical Society, 2021
Lanosterol 14α-demethylase (CYP51) is an important target in the development of antifungal drugs. The fungal-derived restricticin 1 and related molecules are the only examples of natural products that inhibit CYP51.
Nicholas Liu, Elizabeth D Abramyan, Wei Cheng, Bruno Perlatti, Colin J. B. Harvey, G. Bills, Yi Tang   +6 more
semanticscholar   +1 more source

Mining Pure, Strict Epistatic Interactions from High-Dimensional Datasets: Ameliorating the Curse of Dimensionality [PDF]

, 2012
Background: The interaction between loci to affect phenotype is called epistasis. It is strict epistasis if no proper subset of the interacting loci exhibits a marginal effect.
Richard E. Neapolitan, Xia Jiang, Xiaofeng Wang   +2 more
core   +3 more sources

Genome Mining of Chryseobacterium proteolyticum for Keratinolytic Properties and Prospective Applications

Journal of Pure and Applied Microbiology
The manipulation of keratinolytic determinants provides an avenue for enhancing keratinase output, thereby facilitating the conversion of wasted chicken feathers into valuable products.
Lindelwa Mpaka, Nonso E. Nnolim, Uchechukwu U. Nwodo   +2 more
doaj   +1 more source