Results 61 to 70 of about 1,743,586 (380)

A Cell‐Free Platform Based on Nisin Biosynthesis for Discovering Novel Lanthipeptides and Guiding their Overproduction In Vivo

Advanced Science, 2020
Lanthipeptides have extensive therapeutic and industrial applications. However, because many are bactericidal, traditional in vivo platforms are limited in their capacity to discover and mass produce novel lanthipeptides as bacterial organisms are often ...
Ran Liu, Yuchen Zhang, Guoqing Zhai, Shuai Fu, Yao Xia, Ben Hu, Xuan Cai, Yan Zhang, Yan Li, Zixin Deng, Tiangang Liu   +10 more
doaj   +1 more source

Use of whole-genus genome sequence data to develop a multilocus sequence typing tool that accurately identifies Yersinia isolates to the species and subspecies levels [PDF]

, 2015
The genus Yersinia is a large and diverse bacterial genus consisting of human-pathogenic species, a fish-pathogenic species, and a large number of environmental species.
Carniel, Elisabeth, Chattaway, Marie A., Connor, Thomas Richard, Hall, Miquette, Jenkins, Claire, Ledeboer, N. A., McNally, Alan, Rajakaruna, Lakshani, Rajendram, Dunstan, Reuter, Sandra, Savin, Cyril, Strauch, Eckhard, Thomson, Nicholas R., Van Damme, Inge   +13 more
core   +1 more source

Targeted Genome Mining Reveals the Biosynthetic Gene Clusters of Natural Product CYP51 Inhibitors.

Journal of the American Chemical Society, 2021
Lanosterol 14α-demethylase (CYP51) is an important target in the development of antifungal drugs. The fungal-derived restricticin 1 and related molecules are the only examples of natural products that inhibit CYP51.
Nicholas Liu, Elizabeth D Abramyan, Wei Cheng, Bruno Perlatti, Colin J. B. Harvey, G. Bills, Yi Tang   +6 more
semanticscholar   +1 more source

Mining Indonesian Microbial Biodiversity for Novel Natural Compounds by a Combined Genome Mining and Molecular Networking Approach

Marine Drugs, 2021
Indonesia is one of the most biodiverse countries in the world and a promising resource for novel natural compound producers. Actinomycetes produce about two thirds of all clinically used antibiotics.
Ira Handayani, Hamada H. Saad, S. Ratnakomala, P. Lisdiyanti, W. Kusharyoto, Janina Krause, A. Kulik, W. Wohlleben, S. Aziz, H. Gross, A. Gavriilidou, N. Ziemert, Yvonne Mast   +12 more
semanticscholar   +1 more source

Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi

Frontiers in Microbiology, 2015
Genomics has revolutionized the research on fungal secondary metabolite biosynthesis. To elucidate the molecular and enzymatic mechanisms underlying the biosynthesis of a specific secondary metabolite compound, the important first step is often to find ...
Ralph A Cacho, Yi eTang, Yi eTang, Yit-Heng eChooi   +3 more
doaj   +1 more source

Mining Natural Product Biosynthesis in Eukaryotic Algae

Marine Drugs, 2020
Eukaryotic algae are an extremely diverse category of photosynthetic organisms and some species produce highly potent bioactive compounds poisonous to humans or other animals, most notably observed during harmful algal blooms.
Ellis O’Neill
doaj   +1 more source

Underexplored bacteria as reservoirs of novel antimicrobial lipopeptides

Frontiers in Chemistry, 2022
Natural products derived from microorganisms play a prominent role in drug discovery as potential anti-infective agents. Over the past few decades, lipopeptides produced by particularly Bacillus, Pseudomonas, Streptomyces, Paenibacillus, and ...
Tanya Clements-Decker, Megan Kode, Sehaam Khan, Wesaal Khan   +3 more
doaj   +1 more source

Mining microbial genomes for new natural products and biosynthetic pathways [PDF]

, 2008
Analyses of microbial genome sequences have revealed numerous examples of ‘cryptic’ or ‘orphan’ biosynthetic gene clusters, with the potential to direct the production of novel, structurally complex natural products.
Austin, Austin, Banskota, Banskota, Barona-Gómez, Barona-Gómez, Bentley, Bergmann, Bok, Caffrey, Chain, Challis, Challis, Challis, Challis, Chen, Chen, Corre, de Bruijn, Drake, Erb, Fischbach, Fleischmann, Fleming, Funa, Gregory L. Challis, Gross, Gross, Grüschow, Gust, Günter, Haydock, Haynes, Hojati, Hornung, Ikeda, Izumikawa, Kadi, Keller, Koehn, Larsen, Lautru, Lautru, Li, Li, Lin, Lin, McAlpine, Miethke, Minowa, Miyanaga, Muller, Nguyen, Oliynyk, Omura, Paulsen, Petersen, Pfeifer, Rausch, Reid, Song, Stachelhaus, Sudek, Tohyama, Udwary, Wilkinson, Zhao, Zirkle   +67 more
core   +1 more source

Mining the Genome for Therapeutic Targets [PDF]

Diabetes, 2017
Current pharmacological options for type 2 diabetes do not cure the disease. Despite the availability of multiple drug classes that modulate glycemia effectively and minimize long-term complications, these agents do not reverse pathogenesis, and in practice they are not selected to correct the molecular profile specific to the patient.
openaire   +3 more sources

SolRgene: an online database to explore disease resistance genes in tuber-bearing Solanum species [PDF]

, 2011
Background The cultivated potato (Solanum tuberosum L.) is an important food crop, but highly susceptible to many pathogens. The major threat to potato production is the Irish famine pathogen Phytophthora infestans, which causes the devastating late ...
Bakker, E.H., Berloo, R., van, Budding, D.J., Champouret, N., Finkers, H.J., Goverse, A., Hoekstra, R., Huigen, D.J., Jacobs, M.M.J., Jacobsen, E., Krenek, P., Pel, M., Rietman, H., Visser, R.G.F., Vissers, M., Vleeshouwers, V.G.A.A., Vosman, B.   +16 more
core   +2 more sources