Results 11 to 20 of about 5,189,630 (339)

Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the Nucleus.

Cell, 2018
Eukaryotic genomes are packaged into a 3-dimensional structure in the nucleus. Current methods for studying genome-wide structure are based on proximity ligation.
Sofia A. Quinodoz, Noah Ollikainen, B. Tabak, Ali Palla, J. Schmidt, Elizabeth Detmar, M. Lai, Alexander A. Shishkin, Prashant Bhat, Yodai Takei, Vickie Trinh, E. Aznauryan, Pamela Russell, Christine S Cheng, M. Jovanović, A. Chow, L. Cai, P. McDonel, Manuel Garber, M. Guttman   +19 more
semanticscholar   +3 more sources

Human topoisomerases and their roles in genome stability and organization

Nature Reviews Molecular Cell Biology, 2022
Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A and TOP3B) topoisomerases.
Y. Pommier, A. Nussenzweig, S. Takeda, C. Austin   +3 more
semanticscholar   +3 more sources

Expression of concern for global biomedical research by the human genome organization (HUGO) [PDF]

Human Genomics
Cuts to US science funding will stall advances in genomics affecting public health, rare disease and cancer diagnostics and therapeutics in the US and around the world.
Ada Hamosh, Fabiana Arzuaga, Karen B. Avraham, Zilfalil Bin Alwi, Anne Bowcock, Sir John Burn, Piero Carninci, Collet Dandara, Iscia Lopes-Cendes, Leon Mutesa, Partha P. Majumder, Juergen K.V. Reichardt, Joris A. Veltman   +12 more
doaj   +2 more sources

The 3D Genome Browser: A web-based browser for visualizing 3D genome organization and long-range chromatin interactions [PDF]

Genome Biology, 2018
Here, we introduce the 3D Genome Browser, http://3dgenome.org, which allows users to conveniently explore both their own and over 300 publicly available chromatin interaction data of different types.
Choudhary, Mayank N.K., Hardison, Ross, Hu, Ming, Kuang, Da, Li, Daofeng, Li, Yun, Song, Fan, Wang, Ting, Wang, Yanli, Xu, Jie, Yue, Feng, Zhang, Bo, Zhang, Lijun   +12 more
core   +3 more sources

Understanding 3D genome organization by multidisciplinary methods

Nature Reviews Molecular Cell Biology, 2021
I. Jerković, Giacomo Cavalli
semanticscholar   +3 more sources

The Sorghum bicolor reference genome: improved assembly, gene annotations, a transcriptome atlas, and signatures of genome organization. [PDF]

bioRxiv, 2017
Sorghum bicolor is a drought tolerant C4 grass used for the production of grain, forage, sugar, and lignocellulosic biomass and a genetic model for C4 grasses due to its relatively small genome (approximately 800 Mbp), diploid genetics, diverse ...
Amirebrahimi, Mojgan, Grimwood, Jane, Jenkins, Jerry, Kennedy, Megan, Mattison, Ashley, McCormick, Ryan F, McKinley, Brian, Morishige, Daryl T, Mullet, John E, Schmutz, Jeremy, Shu, Shengqiang, Sims, David, Sreedasyam, Avinash, Truong, Sandra K, Weers, Brock D   +14 more
core   +3 more sources

Intertwining roles of R-loops and G-quadruplexes in DNA repair, transcription and genome organization. [PDF]

Nat Cell Biol
Wulfridge P, Sarma K.
europepmc   +2 more sources

Monkeypox (mpox) virus: Classification, origin, transmission, genome organization, antiviral drugs, and molecular diagnosis

Journal of Infection and Public Health, 2023
Monkeypox virus (MPXV) is a double-stranded DNA virus belonging to the Poxviridae family of the genus Orthopoxvirus with two different clades known as West African and Congo Basin.
Aysel Karagoz, H. Tombuloglu, Moneerah Alsaeed, G. Tombuloglu, Abdullah A AlRubaish, A. Mahmoud, Samira Smajlović, Sabahudin Ćordić, A. Rabaan, Ebtesam Alsuhaimi   +9 more
semanticscholar   +1 more source

Genome organization controls transcriptional dynamics during development

Science, 2022
Past studies offer contradictory claims for the role of genome organization in the regulation of gene activity. Here, we show through high-resolution chromosome conformation analysis that the Drosophila genome is organized by two independent classes of ...
P. Batut, X. Bing, Zachary L Sisco, J. Raimundo, M. Levo, M. Levine   +5 more
semanticscholar   +1 more source

Entropy-Driven Genome Organization [PDF]

Biophysical Journal, 2006
DNA and RNA polymerases active on bacterial and human genomes in the crowded environment of a cell are modeled as beads spaced along a string. Aggregation of the large polymerizing complexes increases the entropy of the system through an increase in entropy of the many small crowding molecules; this occurs despite the entropic costs of looping the ...
MARENDUZZO D, Micheletti, Cristian, COOK P. R.   +2 more
openaire   +5 more sources