Results 21 to 30 of about 3,886,811 (311)
The genome as a developmental organ [PDF]
The Journal of Physiology, 2014 AbstractThis paper applies the conceptual toolkit of Evolutionary Developmental Biology (evo‐devo) to the evolution of the genome and the role of the genome in organism development. This challenges both the Modern Evolutionary Synthesis, the dominant view in evolutionary theory for much of the 20th century, and the typically unreflective analysis of ...
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Regional regulation of transcription in the chicken genome [PDF]
, 2010 Background Over the past years, the relationship between gene transcription and chromosomal location has been studied in a number of different vertebrate genomes. Regional differences in gene expression have been found in several different species.
Nie, H. +9 more
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Radial genome organization [PDF]
Nature Methods, 2020 Sequencing gradually digested chromatin along the nuclear radius enables the mapping of radial organization of chromatin in human cells.
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Chromatin conformation regulates the coordination between DNA replication and transcription
Nature Communications, 2018 The maintenance of chromatin integrity during replication is critical for cell viability. Here the authors study how dividing cells respond to alterations in chromatin structure and find that these elicit a range of responses in the dynamics of DNA ...
Ricardo Almeida +8 more
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Generation of genetic constructs that simultaneously express several shRNAs
BioTechniques, 2012 RNAi has potential as an antiviral gene therapy strategy. Cassette constructs simultaneously expressing several siRNAs could prove to be the most efficient technique in developing gene therapy approaches for highly mutable viruses such as HIV-1.
Olga V. Kretova +2 more
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Specificity, propagation, and memory of pericentric heterochromatin
Molecular Systems Biology, 2014 The cell establishes heritable patterns of active and silenced chromatin via interacting factors that set, remove, and read epigenetic marks. To understand how the underlying networks operate, we have dissected transcriptional silencing in pericentric ...
Katharina Müller‐Ott +11 more
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MGERT: a pipeline to retrieve coding sequences of mobile genetic elements from genome assemblies
Mobile DNA, 2019 Background Genomes of eukaryotes are inhabited by myriads of mobile genetic elements (MGEs) – transposons and retrotransposons - which play a great role in genome plasticity and evolution.
Andrei S. Guliaev +1 more
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Transcriptionally Driven DNA Replication Program of the Human Parasite Leishmania major
Cell Reports, 2016 Faithful inheritance of eukaryotic genomes requires the orchestrated activation of multiple DNA replication origins (ORIs). Although origin firing is mechanistically conserved, how origins are specified and selected for activation varies across different
Rodrigo Lombraña +8 more
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Aurora Kinase B Regulates Telomerase Activity via a Centromeric RNA in Stem Cells
Cell Reports, 2015 Non-coding RNAs can modulate histone modifications that, at the same time, affect transcript expression levels. Here, we dissect such a network in mouse embryonic stem cells (ESCs). It regulates the activity of the reverse transcriptase telomerase, which
Jan-Philipp Mallm, Karsten Rippe
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The Plant Pathology Journal, 2020 Sugarcane yellow leaf virus (SCYLV) is a distinct member of the Polerovirus genus of the Luteoviridae family. SCYLV is the major limitation to sugarcane production worldwide and presently occurring in most of the sugarcane growing countries. SCYLV having
Somnath Kadappa Holkar +10 more
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