Results 21 to 30 of about 5,189,630 (339)

Phase Separation in Genome Organization across Evolution.

Trends in Cell Biology, 2021
Phase separation is emerging as a paradigm to explain the self-assembly and organization of membraneless bodies in the cell. Recent advances show that this principle also extends to nucleoprotein complexes, including DNA-based structures. We discuss here
Marina Feric, T. Misteli
semanticscholar   +1 more source

Radial genome organization [PDF]

Nature Methods, 2020
Sequencing gradually digested chromatin along the nuclear radius enables the mapping of radial organization of chromatin in human cells.
openaire   +2 more sources

Super-Enhancers, Phase-Separated Condensates, and 3D Genome Organization in Cancer

Cancers, 2022
Simple Summary Gene expression is primarily controlled at the level of transcription, largely due to binding of transcription factors to specific sites on DNA, namely super-enhancers and promoters. Super-enhancers and enhancers can regulate distal target
Seng Chuan Tang, Udhaya Vijayakumar, Ying Zhang, M. Fullwood   +3 more
semanticscholar   +1 more source

The Myc-associated zinc finger protein (MAZ) works together with CTCF to control cohesin positioning and genome organization

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance The protein CTCF plays a major role in large-scale organization of the genome. Binding sites for the protein MAZ are found adjacent to many CTCF sites. We show that, at such double sites, MAZ stabilizes CTCF binding.
Tiaojiang Xiao, Xin Li, G. Felsenfeld
semanticscholar   +1 more source

Multiscale modeling of genome organization with maximum entropy optimization

Journal of Chemical Physics, 2021
Three-dimensional (3D) organization of the human genome plays an essential role in all DNA-templated processes, including gene transcription, gene regulation, and DNA replication. Computational modeling can be an effective way of building high-resolution
Xingcheng Lin, Yifeng Qi, Andrew P. Latham, Bin Zhang   +3 more
semanticscholar   +1 more source

DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity.

Cell Reports, 2021
DNA replication timing and three-dimensional (3D) genome organization are associated with distinct epigenome patterns across large domains. However, whether alterations in the epigenome, in particular cancer-related DNA hypomethylation, affects higher ...
Q. Du, Grady C. Smith, Phuc-Loi Luu, James M. Ferguson, Nicola J. Armstrong, C. Caldon, Elyssa M. Campbell, Shalima Nair, E. Zotenko, Cathryn M. Gould, Michael Buckley, K. Chia, N. Portman, E. Lim, D. Kaczorowski, Chia-Ling Chan, K. Barton, I. Deveson, Martin A. Smith, J. Powell, Ksenia Skvortsova, C. Stirzaker, Joanna Achinger-Kawecka, S. Clark   +23 more
semanticscholar   +1 more source

Machine learning methods for exploring sequence determinants of 3D genome organization.

Journal of Molecular Biology, 2022
In higher eukaryotic cells, chromosomes are folded inside the nucleus. Recent advances in whole-genome mapping technologies have revealed the multiscale features of 3D genome organizations that are intertwined with fundamental genome functions.
Muyu Yang, Jian-xing Ma
semanticscholar   +1 more source

Lamin C is required to establish genome organization after mitosis

Genome Biology, 2021
The dynamic 3D organization of the genome is central to gene regulation and development. The nuclear lamina influences genome organization through the tethering of lamina-associated domains (LADs) to the nuclear periphery. Evidence suggests that lamins A
X. Wong, Victoria E. Hoskins, Ashley J Melendez-Perez, Jennifer C. Harr, M. Gordon, K. Reddy   +5 more
semanticscholar   +1 more source

Understanding 3D Genome Organization and Its Effect on Transcriptional Gene Regulation Under Environmental Stress in Plant: A Chromatin Perspective

Frontiers in Cell and Developmental Biology, 2021
The genome of a eukaryotic organism is comprised of a supra-molecular complex of chromatin fibers and intricately folded three-dimensional (3D) structures.
Suresh Kumar, S. Kaur, K. Seem, Santosh Kumar, T. Mohapatra   +4 more
semanticscholar   +1 more source

Organization of the Pluripotent Genome [PDF]

Cold Spring Harbor Perspectives in Biology, 2020
In the past several decades, the establishment of in vitro models of pluripotency has ushered in a golden era for developmental and stem cell biology. Research in this arena has led to profound insights into the regulatory features that shape early embryonic development.
Lim, Patrick S.L., Meshorer, Eran
openaire   +2 more sources