Results 31 to 40 of about 5,189,630 (339)

The stochastic nature of genome organization and function.

Current Opinion in Genetics and Development, 2021
Genomes have complex three-dimensional structures. High-resolution population-based biochemical studies over the last decade have painted a mostly static picture of the genome characterized by universal organizational features, such as chromatin domains ...
Varun Sood, T. Misteli
semanticscholar   +1 more source

Environmental Enrichment Induces Epigenomic and Genome Organization Changes Relevant for Cognition

Frontiers in Molecular Neuroscience, 2021
In early development, the environment triggers mnemonic epigenomic programs resulting in memory and learning experiences to confer cognitive phenotypes into adulthood. To uncover how environmental stimulation impacts the epigenome and genome organization,
S. Espeso-Gil, A. Holik, Sarah Bonnin, S. Jhanwar, Sandhya Chandrasekaran, R. Pique-Regi, Júlia Albaigès-Ràfols, Michael Maher, Jon Permanyer, M. Irimia, M. Friedländer, Meritxell Pons-Espinal, S. Akbarian, M. Dierssen, P. Maass, Charlotte N. Hor, S. Ossowski   +16 more
semanticscholar   +1 more source

Enhanced FnCas12a-Mediated Targeted Mutagenesis Using crRNA With Altered Target Length in Rice

Frontiers in Genome Editing, 2020
The CRISPR/Cas12a (Cpf1) system utilizes a thymidine-rich protospacer adjacent motif (PAM) and generates DNA ends with a 5′ overhang. These properties differ from those of CRISPR/Cas9, making Cas12a an attractive alternative in the CRISPR toolbox ...
Katsuya Negishi, Masafumi Mikami, Masafumi Mikami, Seiichi Toki, Seiichi Toki, Seiichi Toki, Masaki Endo, Masaki Endo   +7 more
doaj   +1 more source

The CACTA transposon Bot1 played a major role in Brassica genome divergence and gene proliferation [PDF]

, 2008
We isolated and characterized a Brassica C genome-specific CACTA element, which was designated Bot1 (Brassica oleracea transposon 1). After analysing phylogenetic relationships, copy numbers and sequence similarity of Bot1 and Bot1 analogues in B ...
AGI, Arabidopsis Genome Initiative, Alix, Alix, Alix, Bandelt, Bateman, Bennetzen, Brunner, Casacuberta, Cui, Darling, DeMarco, Deragon, Edgar, Eichler, Fedoroff, Feschotte, Gaeta, Gish, Grandbastien, Hawkins, He, Heslop-Harrison, IHGSC, Inaba, Inagaki, Itoh, Jacobs, Jiang, Johnston, Kapitonov, Kapitonov, Kawasaki, Kazazian, Kubis, Kubis, Kuhn, Kurtz, Le, Leflon, Lenoir, Lysak, Maddison, Meyers, Miura, Morgante, Morgante, Nacken, Nicolas, Ozeki, O’Neill, Pereira, Peterson, Posada, Rocarro, Rodríguez, Schwarzacher, Shiba, Snowden, Snowdon, Sonnhammer, Strachan, Suzuki, Swofford, Talbert, Town, Turcotte, U, Vicient, Walbot, Wang, Wendel, Wicker, Wicker, Yang, Yang, Yu, Zabala, Zabala, Zhang, Zhang   +80 more
core   +1 more source

Regulation of mammalian 3D genome organization and histone H3K9 dimethylation by H3K9 methyltransferases

Communications Biology, 2021
Histone H3 lysine 9 dimethylation (H3K9me2) is a highly conserved silencing epigenetic mark. Chromatin marked with H3K9me2 forms large domains in mammalian cells and overlaps well with lamina-associated domains and the B compartment defined by Hi-C ...
Kei Fukuda, Chikako Shimura, Hisashi Miura, Akie Tanigawa, Takehiro Suzuki, N. Dohmae, I. Hiratani, Y. Shinkai   +7 more
semanticscholar   +1 more source

Genomic organization of microRNAs [PDF]

Journal of Cellular Physiology, 2009
AbstractmicroRNAs (miRNAs) are small (∼22 nt) noncoding RNAs that have been shown to regulate gene expression post‐transcriptionally. They function by pairing with the 3′ UTR of target mRNAs and repressing translation or by targeting the mRNA for degradation.
Abigail F, Olena, James G, Patton
openaire   +2 more sources

Generation of genetic constructs that simultaneously express several shRNAs

BioTechniques, 2012
RNAi has potential as an antiviral gene therapy strategy. Cassette constructs simultaneously expressing several siRNAs could prove to be the most efficient technique in developing gene therapy approaches for highly mutable viruses such as HIV-1.
Olga V. Kretova, Ildar R. Alembekov, Nickolai A. Tchurikov   +2 more
doaj   +1 more source

Chromatin conformation regulates the coordination between DNA replication and transcription

Nature Communications, 2018
The maintenance of chromatin integrity during replication is critical for cell viability. Here the authors study how dividing cells respond to alterations in chromatin structure and find that these elicit a range of responses in the dynamics of DNA ...
Ricardo Almeida, José Miguel Fernández-Justel, Cristina Santa-María, Jean-Charles Cadoret, Laura Cano-Aroca, Rodrigo Lombraña, Gonzalo Herranz, Alessandra Agresti, María Gómez   +8 more
doaj   +1 more source

Complete Genome Sequence of Diaphorina citri-associated C virus, a Novel Putative RNA Virus of the Asian Citrus Psyllid, Diaphorina citri. [PDF]

, 2016
We present here the complete nucleotide sequence and genome organization of a novel putative RNA virus identified in field populations of the Asian citrus psyllid, Diaphorina citri, through sequencing of the transcriptome followed by reverse ...
Falk, Bryce W, Nouri, Shahideh, Salem, Nidà   +2 more
core   +1 more source

MGERT: a pipeline to retrieve coding sequences of mobile genetic elements from genome assemblies

Mobile DNA, 2019
Background Genomes of eukaryotes are inhabited by myriads of mobile genetic elements (MGEs) – transposons and retrotransposons - which play a great role in genome plasticity and evolution.
Andrei S. Guliaev, Seraphima K. Semyenova   +1 more
doaj   +1 more source