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100K Pathogen Genome Project. [PDF]

open access: yesGenome Announc, 2017
The 100K Pathogen Genome Project is producing draft and closed genome sequences from diverse pathogens. This project expanded globally to include a snapshot of global bacterial genome diversity.
Weimer BC.
europepmc   +3 more sources

The Human Genome Project and the Downside of Federal Technology Transfer [PDF]

open access: green, 1994
Mr. Harnett argues that emphasizing technology transfer at institutions such as the National Institutes of Health will interfere with what should be regarded as their primary mission, basic ...
Harnett, Christopher J.
core   +4 more sources

Epigenetic effects toward new insights as potential therapeutic target in B-thalassemia

open access: yesJournal of Genetic Engineering and Biotechnology, 2021
Background Fetal hemoglobin (HbF) induction has shown promise for the treatment of β-hemoglobinopathies. HbF induction in β-thalassemia could overcome ineffective hematopoiesis and thus terminate transfusion dependency for formerly transfusion dependant ...
Noha Hamdy Eltaweel   +4 more
doaj   +1 more source

Characterization of tumor-associated reactive astrocytes in gliomas by single-cell and bulk tumor sequencing

open access: yesFrontiers in Neurology, 2023
ObjectiveAstrocytes constitute approximately 30% of cells in gliomas and play important roles in synapse construction and survival. Recently, JAK/STAT pathway activation associated with a new type of astrocyte was reported.
Chuan-bao Zhang   +9 more
doaj   +1 more source

Towards the Physical Map of the Trypanosoma cruzi Nuclear Genome: Construction of YAC and BAC Libraries of the Reference Clone T. cruzi CL-Brener [PDF]

open access: yesMemorias do Instituto Oswaldo Cruz, 1997
Strategies to construct the physical map of the Trypanosoma cruzi nuclear genome have to capitalize on three main advantages of the parasite genome, namely (a) its small size, (b) the fact that all chromosomes can be defined, and many of them can be ...
I Ferrari   +31 more
doaj   +1 more source

Importance of HBsAg recognition by HLA molecules as revealed by responsiveness to different hepatitis B vaccines

open access: yesScientific Reports, 2021
Hepatitis B (HB) vaccines (Heptavax-II and Bimmugen) designed based on HBV genotypes A and C are mainly used for vaccination against HB in Japan. To determine whether there are differences in the genetic background associated with vaccine responsiveness,
Nao Nishida   +23 more
doaj   +1 more source

The Deep Genome Project [PDF]

open access: yesGenome Biology, 2020
K. C. Kent Lloyd   +43 more
doaj   +2 more sources

Claspin-Dependent and -Independent Chk1 Activation by a Panel of Biological Stresses

open access: yesBiomolecules, 2023
Replication stress has been suggested to be an ultimate trigger of carcinogenesis. Oncogenic signal, such as overexpression of CyclinE, has been shown to induce replication stress. Here, we show that various biological stresses, including heat, oxidative
Hao-Wen Hsiao   +2 more
doaj   +1 more source

Genome-wide copy number variation analysis of hepatitis B infection in a Japanese population

open access: yesHuman Genome Variation, 2021
Hepatitis B: Gene copy numbers associated with risk of infection The risk of contracting the hepatitis B virus may be linked to the number of copies of certain genes in an individual’s genome.
Masataka Kikuchi   +7 more
doaj   +1 more source

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