Results 1 to 10 of about 707,839 (119)

The International Human Genome Project [PDF]

Human Molecular Genetics, 2021
Ewan Birney, Birney Ewan
exaly   +2 more sources

Epigenetic effects toward new insights as potential therapeutic target in B-thalassemia

Journal of Genetic Engineering and Biotechnology, 2021
Background Fetal hemoglobin (HbF) induction has shown promise for the treatment of β-hemoglobinopathies. HbF induction in β-thalassemia could overcome ineffective hematopoiesis and thus terminate transfusion dependency for formerly transfusion dependant ...
Noha Hamdy Eltaweel, Ghada Youssef ElKamah, Rabab Khairat, Hanan Abd Elmawgoud Atia, Khalda S. Amr   +4 more
doaj   +1 more source

Characterization of tumor-associated reactive astrocytes in gliomas by single-cell and bulk tumor sequencing

Frontiers in Neurology, 2023
ObjectiveAstrocytes constitute approximately 30% of cells in gliomas and play important roles in synapse construction and survival. Recently, JAK/STAT pathway activation associated with a new type of astrocyte was reported.
Chuan-bao Zhang, Chuan-bao Zhang, Zhi-liang Wang, Zhi-liang Wang, Han-jie Liu, Han-jie Liu, Zheng Wang, Zheng Wang, Wang Jia, Wang Jia   +9 more
doaj   +1 more source

Towards the Physical Map of the Trypanosoma cruzi Nuclear Genome: Construction of YAC and BAC Libraries of the Reference Clone T. cruzi CL-Brener [PDF]

Memorias do Instituto Oswaldo Cruz, 1997
Strategies to construct the physical map of the Trypanosoma cruzi nuclear genome have to capitalize on three main advantages of the parasite genome, namely (a) its small size, (b) the fact that all chromosomes can be defined, and many of them can be ...
I Ferrari, H Lorenzi, MR Santos, S Brandariz, JM Requena, A Schijman, M Vázquez, JF da Silveira, C Ben-Dov, C Medrano, S Ghío, P López Bergami, I Cano, B Zingales, TP Urmenyi, E Rondinelli, A González, A Cortes, MC Lopez, MC Thomas, C Alonso, JL Ramírez, MA Chiurrillo, R Rangel Aldao, A Brandão, W Degrave, V Perrot, M Saumier, A Billaut, D Cohen, D Le Paslier, MJ Levin   +31 more
doaj   +1 more source

Importance of HBsAg recognition by HLA molecules as revealed by responsiveness to different hepatitis B vaccines

Scientific Reports, 2021
Hepatitis B (HB) vaccines (Heptavax-II and Bimmugen) designed based on HBV genotypes A and C are mainly used for vaccination against HB in Japan. To determine whether there are differences in the genetic background associated with vaccine responsiveness,
Nao Nishida, Masaya Sugiyama, Jun Ohashi, Yosuke Kawai, Seik-Soon Khor, Sohji Nishina, Kazumi Yamasaki, Hirohisa Yazaki, Kaori Okudera, Akihiro Tamori, Yuichiro Eguchi, Aiko Sakai, Keisuke Kakisaka, Hiromi Sawai, Takayo Tsuchiura, Miyuki Ishikawa, Keisuke Hino, Ryo Sumazaki, Yasuhiro Takikawa, Tatsuo Kanda, Osamu Yokosuka, Hiroshi Yatsuhashi, Katsushi Tokunaga, Masashi Mizokami   +23 more
doaj   +1 more source

Claspin-Dependent and -Independent Chk1 Activation by a Panel of Biological Stresses

Biomolecules, 2023
Replication stress has been suggested to be an ultimate trigger of carcinogenesis. Oncogenic signal, such as overexpression of CyclinE, has been shown to induce replication stress. Here, we show that various biological stresses, including heat, oxidative
Hao-Wen Hsiao, Chi-Chun Yang, Hisao Masai   +2 more
doaj   +1 more source

Genome-wide copy number variation analysis of hepatitis B infection in a Japanese population

Human Genome Variation, 2021
Hepatitis B: Gene copy numbers associated with risk of infection The risk of contracting the hepatitis B virus may be linked to the number of copies of certain genes in an individual’s genome.
Masataka Kikuchi, Kaori Kobayashi, Nao Nishida, Hiromi Sawai, Masaya Sugiyama, Masashi Mizokami, Katsushi Tokunaga, Akihiro Nakaya   +7 more
doaj   +1 more source

Analysis of SARS-CoV-2 genomic epidemiology reveals disease transmission coupled to variant emergence and allelic variation

Scientific Reports, 2021
The spread of SARS-CoV-2 created a pandemic crisis with > 150,000 cumulative cases in > 65 countries within a few months. The reproductive number (R) is a metric to estimate the transmission of a pathogen during an outbreak.
D J Darwin R. Bandoy, Bart C. Weimer
doaj   +1 more source

Correction: Hsiao et al. Claspin-Dependent and -Independent Chk1 Activation by a Panel of Biological Stresses. Biomolecules 2023, 13, 125

Biomolecules, 2023
In the original publication [...]
Hao-Wen Hsiao, Chi-Chun Yang, Hisao Masai   +2 more
doaj   +1 more source

Molecular tools to monitor health and disease – and lucky coincidences

Upsala Journal of Medical Sciences, 2022
Improved methods for molecular analyses are obviously central for medical research. I will describe herein our work developing tools to reveal molecular states in health and disease.
Ulf Landegren
doaj   +1 more source