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100K Pathogen Genome Project. [PDF]
Genome Announc, 2017 The 100K Pathogen Genome Project is producing draft and closed genome sequences from diverse pathogens. This project expanded globally to include a snapshot of global bacterial genome diversity.
Weimer BC.
europepmc +8 more sources
Genome Biology, 2020 In vivo research is critical to the functional dissection of multi-organ systems and whole organism physiology, and the laboratory mouse remains a quintessential animal model for studying mammalian, especially human, pathobiology. Enabled by technological innovations in genome sequencing, mutagenesis and genome editing, phenotype analyses, and ...
K. C. Kent Lloyd +43 more
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Briefings in Functional Genomics and Proteomics, 2008 The medaka Oryzias latipes is a small egg-laying freshwater teleost, and has become an excellent model system for ecotoxicology, developmental genetics, genomics and evolutionary biology studies. A high-quality draft genome sequence (700 Mb) of the medaka inbred strain, Hd-rR, has now been completed. In this review, we present an overview of the medaka
Daisuke, Kobayashi, Hiroyuki, Takeda
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Epigenetic effects toward new insights as potential therapeutic target in B-thalassemia
Journal of Genetic Engineering and Biotechnology, 2021 Background Fetal hemoglobin (HbF) induction has shown promise for the treatment of β-hemoglobinopathies. HbF induction in β-thalassemia could overcome ineffective hematopoiesis and thus terminate transfusion dependency for formerly transfusion dependant ...
Noha Hamdy Eltaweel +4 more
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Frontiers in Neurology, 2023 ObjectiveAstrocytes constitute approximately 30% of cells in gliomas and play important roles in synapse construction and survival. Recently, JAK/STAT pathway activation associated with a new type of astrocyte was reported.
Chuan-bao Zhang +9 more
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Towards the Physical Map of the Trypanosoma cruzi Nuclear Genome: Construction of YAC and BAC Libraries of the Reference Clone T. cruzi CL-Brener [PDF]
Memorias do Instituto Oswaldo Cruz, 1997 Strategies to construct the physical map of the Trypanosoma cruzi nuclear genome have to capitalize on three main advantages of the parasite genome, namely (a) its small size, (b) the fact that all chromosomes can be defined, and many of them can be ...
I Ferrari +31 more
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Scientific Reports, 2021 Hepatitis B (HB) vaccines (Heptavax-II and Bimmugen) designed based on HBV genotypes A and C are mainly used for vaccination against HB in Japan. To determine whether there are differences in the genetic background associated with vaccine responsiveness,
Nao Nishida +23 more
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Genomic Standards Consortium Projects [PDF]
Standards in Genomic Sciences, 2014 The Genomic Standards Consortium (GSC) is an open-membership community that was founded in 2005 to work towards the development, implementation and harmonization of standards in the field of genomics. Starting with the defined task of establishing a minimal set of descriptions the GSC has evolved into an active standards-setting body that currently has
Field D +28 more
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Genome-wide copy number variation analysis of hepatitis B infection in a Japanese population
Human Genome Variation, 2021 Hepatitis B: Gene copy numbers associated with risk of infection The risk of contracting the hepatitis B virus may be linked to the number of copies of certain genes in an individual’s genome.
Masataka Kikuchi +7 more
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Claspin-Dependent and -Independent Chk1 Activation by a Panel of Biological Stresses
Biomolecules, 2023 Replication stress has been suggested to be an ultimate trigger of carcinogenesis. Oncogenic signal, such as overexpression of CyclinE, has been shown to induce replication stress. Here, we show that various biological stresses, including heat, oxidative
Hao-Wen Hsiao +2 more
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