Results 191 to 200 of about 5,972,699 (372)

A “Quality-First” Credo for the Human Genome Project [PDF]

, 1998
Maynard V. Olson, Phil Green
openalex   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

The Sphagnum Genome Project [PDF]

, 2016
Altschul, Andrus, Beike, Benfey, Bower, Chiang, Clymo, Cornelissen, Dhondt, Erxleben, Floyd, Gorham, Grabherr, Graham, Granath, Greb, Haas, Haeckel, Haig, Hajek, Hohe, Johnson, Johnson, Kamisugi, Karlin, Kendrick, Knack, Kyrkjeeide, Langmead, Li, Lindo, Liu, McQueen, Qiu, Redecker, Rensing, Ricca, Rubinstein, Rydin, Rydin, Sarnighausen, Shaw, Shaw, Simola, Steemans, Turetsky, van Breemen, Viaene, Vitt, Wang, Waters, Wellman, Weston, Wickett, Wu, Yu   +55 more
core   +1 more source

Decoding psychosis: from national genome project to national brain project. [PDF]

Gen Psychiatr, 2022
Sun L, Xu M, Shi Y, Xu Y, Chen J, He L.
europepmc   +1 more source

Genome projects and gene pools: New germplasm for plant breeding? [PDF]

, 1998
Michael Lee
openalex   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Precision medicine via the integration of phenotype-genotype information in neonatal genome project. [PDF]

Fundam Res, 2022
Dong X, Xiao T, Chen B, Lu Y, Zhou W.
europepmc   +1 more source

The Organelle Genome Database Project (GOBASE) [PDF]

, 1998
Maria Korab-Laskowska, Pierre Rioux, Nicolas Brossard, Timothy G. Littlejohn, Michael W. Gray, B. Franz Lang, Gertraud Burger   +6 more
openalex   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source