Results 81 to 90 of about 1,107,385 (165)

HIV-1 Lethality and Loss of Env Protein Expression Induced by Single Synonymous Substitutions in the Virus Genome Intronic-Splicing Silencer

Journal of Virology, 2020
Synonymous substitutions can influence virus phenotype, replication capacity, and virulence. In this study, we explored how synonymous codon mutations impacted HIV-1 Env protein expression and virus replication capacity. We changed a single codon, AGG to
A. Jordan-Paiz, M. Nevot, Kevin Lamkiewicz, M. Lataretu, S. Franco, Manja Marz, M. Martínez   +6 more
semanticscholar   +1 more source

The EUROmediCAT Network and Databases: A Resource for Pharmacovigilance in Pregnancy

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 5, May 2026.
ABSTRACT Background The evidence gap relating to the risk of congenital anomalies (CA) associated with first trimester medication exposure in pregnancy is well recognized. Aims We describe the EUROmediCAT network and databases, and the methodological approach to pregnancy pharmacovigilance.
Helen Dolk, Christine Damase‐Michel, Joan Morris, Amanda Neville, Ester Garne, Sue Jordan, Anke Rissmann, Alessio Coi, Deirdre Folan, Dieuwke Broekstra, Jennifer M. Broughan, Lea Bruneau, Clara Cavero‐Carbonell, Elly den Hond, Miriam Gatt, Mika Gissler, Babak Khoshnood, Anna Latos Bielenska, Hedvig Nordeng, Ljubica Odak, Mary O'Mahony, Isabelle Perthus, J. Luke Richardson, Florence Rouget, Joanna Sichitiu, David Tucker, Natalya Zymak‐Zakutnya, Maria Loane   +27 more
wiley   +1 more source

The effect of increased CpG and UpA dinucleotides in the West Nile virus genome on virus transmission by Culex mosquitoes and pathogenesis in a vertebrate host

bioRxiv
Vertebrate animals and many small DNA and single-stranded RNA viruses that infect vertebrates have evolved to suppress genomic CpG dinucleotides. All organisms and most viruses additionally suppress UpA dinucleotides in protein coding RNA.
J. V. van Bree, Imke Visser, E. M. Marshall, Wessel Willemsen, Carmen van de Waterbeemd, Marleen H. C. Abma-Henkens, G. Pijlman, Monique M. van Oers, Barry Rockx, J. Fros   +9 more
semanticscholar   +1 more source

Glyco-recoded Escherichia coli: Recombineering-based genome editing of native polysaccharide biosynthesis gene clusters.

Metabolic Engineering, 2019
Recombineering-based redesign of bacterial genomes by adding, removing or editing large segments of genomic DNA is emerging as a powerful technique for expanding the range of functions that an organism can perform.
Laura E. Yates, A. Natarajan, Mingji Li, M. E. Hale, D. C. Mills, M. DeLisa   +5 more
semanticscholar   +1 more source

Genomic maps of rescue mutants for wildtype DENV2 and DENV2-rcCap-Env.

, 2023
Approximate location of recapitulatory rescue mutations are shown above the genome. Approximate region of recoding is shown below the genome. (PDF)
Wei-Xin Chin (843752), Xin Jun Hou (17291254), Zi Yun Teo (17291245), Antson Kiat Yee Tan (17291257), Yue Wan (301736), Thinesshwary Yogarajah (7871879), Justin Jang Hann Chu (7310267), Regina Ching Hua Lee (17291251), Roland G. Huber (109002), Hao Yuin Kong (17291239), Yu Cai (112178), Isabelle Xin Yu Zhu (17291242), Bowen Yi (11579422), Si Xian Ho (10125726), Zhen Qin Aw (11828321), Regina Faruk (17291248)   +15 more
core   +1 more source

Rewriting the genome of Escherichia coli

, 2021
Our recently acquired ability to synthesize DNA at large scale is opening the door to writing entire genomes; this constitutes a powerful approach to address fundamental biological questions, and may enable the creation of designer organisms with useful ...

core   +1 more source

Dominis estructurals i noves interaccions proteiques de l'enzim deubiquitinant USP25 [PDF]

, 2011
[cat] La present Tesi Doctoral es presenta com una agrupació de quatre publicacions que resumeixen el treball realitzat al Departament de Genètica de la Facultat de Biologia de la Universitat de Barcelona.
Denuc Isern, Amanda
core  

Genomically recoded Escherichia coli with optimized functional phenotypes

Abstract Genomically recoded organisms hold promise for many biotechnological applications, but they may exhibit substantial fitness defects relative to their non-recoded counterparts. We used targeted metabolic screens, genetic analysis, and proteomics to identify the origins of fitness impairment in a model recoded ...
Colin Hemez, Kyle Mohler, Felix Radford, Jack Moen, Jesse Rinehart, Farren J. Isaacs   +5 more
openaire   +2 more sources

Messenger RNA Sequence Rather than Protein Sequence Determines the Level of Self-synthesis and Antigen Presentation of the EBV-encoded Antigen, EBNA1

, 2012
peer-reviewedViruses establishing persistent latent infections have evolved various mechanisms to avoid immune surveillance. The Epstein-Barr virus-encoded nuclear antigen, EBNA1, expressed in all EBV-associated malignancies, modulates its own protein ...
David J Lynn, Judy T Tellam, Rajiv Khanna, David J. Lynn (107188), Lea Lekieffre, Lynn, David J, Khanna, Rajiv, Judy T. Tellam (107182), Zhong, Jie, Jie Zhong (39213), Tellam, Judy T, Jie Zhong, Rajiv Khanna (107190), Lea Lekieffre (107185), Lekieffre, Lea   +14 more
core   +1 more source

Recoding the gift relationship: views on introducing genomic testing to blood donation

New Genetics and Society
This study examines how the institutional context informs the ways in which healthy recipients relate to genomic information. Through focus group data, it considers the trend of blood collection agencies (BCA) moving to extend donor genotyping. We investigated how receipt of genomic information is viewed as fitting into the contract of altruistic ...
Rachel Thorpe, Vera Raivola, Barbara Masser   +2 more
openaire   +5 more sources