Results 71 to 80 of about 1,107,385 (165)

Sequences Promoting Recoding Are Singular Genomic Elements

, 2009
The distribution of sequences which induce non-standard decoding, especially of shift-prone sequences, is very unusual. On one hand, since they can disrupt standard genetic readout, they are avoided within the coding regions of most genes. On the other hand, they play important regulatory roles for the expression of those genes where they do occur.
Baranov, Pavel V., Gurvich, Olga
openaire   +1 more source

Data_Sheet_1_CpG-Recoding in Zika Virus Genome Causes Host-Age-Dependent Attenuation of Infection With Protection Against Lethal Heterologous Challenge in Mice.PDF

, 2020
Experimental increase of CpG dinucleotides in an RNA virus genome impairs infection providing a promising approach for vaccine development. While CpG recoding is an emerging and promising vaccine approach, little is known about infection phenotypes ...
Colette Wheler (8354508), Marie-Jocelyne Martel (8354511), Volker Gerdts (76764), Ivan Trus (5534489), Daniel Udenze (7039640), Nathalie Berube (7039643), Uladzimir Karniychuk (5577443)   +6 more
core   +1 more source

Genetic architecture of angular leaf spot resistance in cultivated strawberry shaped by epistasis and genotype‐by‐environment interactions

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Angular leaf spot (ALS), caused by Xanthomonas fragariae, is a bacterial disease that limits strawberry (Fragaria × ananassa) productivity worldwide. Although major resistance loci have been identified in wild Fragaria species, their introgression into elite germplasm remains constrained by linkage drag and inconsistent inheritance. To dissect
Shai Torgeman, Dominique D. A. Pincot, Marta Bjornson, Randi A. Famula, Paul Skillin, Allison Krill‐Brown, Mitchell J. Feldmann   +6 more
wiley   +1 more source

The first A-to-I RNA editome of hemipteran species Coridius chinensis reveals overrepresented recoding and prevalent intron editing in early-diverging insects

Cellular and Molecular Life Sciences
Background Metazoan adenosine-to-inosine (A-to-I) RNA editing resembles A-to-G mutation and increases proteomic diversity in a temporal-spatial manner, allowing organisms adapting to changeable environment.
Y. Duan, Ling Ma, Jiyao Liu, Xinzhi Liu, Fan Song, Li Tian, Wanzhi Cai, Hu Li   +7 more
semanticscholar   +1 more source

Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis

Genome Biology, 2017
Adenosine-to-inosine (A-to-I) editing of dsRNA by ADAR proteins is a pervasive epitranscriptome feature. Tens of thousands of A-to-I editing events are defined in the mouse, yet the functional impact of most is unknown.
Jacki E. Heraud-Farlow, A. Chalk, Sandra Linder, Qin Li, Scott Taylor, J. White, Lokman Pang, Brian J. Liddicoat, Ankita Gupte, J. B. Li, Carl R Walkley   +10 more
semanticscholar   +1 more source

Harnessing S. cerevisiae to advance the engineering of pentatricopeptide repeat proteins

The FEBS Journal, Volume 293, Issue 11, Page 3135-3139, June 2026.
Heterologous expression systems have been instrumental in furthering our understanding of plant RNA editing proteins. In this commentary, we discuss how the establishment of yeast as a model for studying plant RNA editing by Ramanathan et al. could advance the engineering of pentatricopeptide repeat proteins, and how in return pentatricopeptide repeat ...
Farley M. Kwok van der Giezen, Ian Small
wiley   +1 more source

Lost in translation : The biogenesis of non-LTR retrotransposon proteins

, 2013
This research was supported by UK Biotechnology and Biological Sciences Research Council (BBSRC) and the Wellcome Trust.“Young” APE-type non-LTR retrotransposons (non-LTRs) typically encode two open reading frames (ORFs 1 and 2).
Roulston, Claire, Odon, Valerie, Odon, V, de Felipe, Pablo, Sukhodub, Andriy, Ryan, MD, Ryan, Martin Denis, Roulston, C, Luke, GA, de Felipe, P, Sukhodub, A, Luke, Garry Alec   +11 more
core   +1 more source

Nucleomorph phylogenomics suggests a deep and ancient origin of cryptophyte plastids within Rhodophyta

New Phytologist, Volume 250, Issue 5, Page 3103-3113, June 2026.
Summary The evolutionary origin of red algae‐derived complex plastids remains obscure. Cryptophyta, one of four eukaryotic lineages harboring these plastids, still contains nucleomorphs, which are highly reduced remnants of red algal nuclei. The genes present on nucleomorph genomes can be used for phylogenomic reconstruction in order to unravel the ...
Lukáš V. F. Novák, Sergio A. Muñoz‐Gómez, Maria Ciobanu, Fabian van Beveren, Laura Eme, Purificación López‐García, David Moreira   +6 more
wiley   +1 more source

Losing genes, gaining edits: how relaxed selection and inverted repeat expansion shape RNA editing in Schizaeaceae plastomes

The Plant Journal, Volume 126, Issue 5, June 2026.
SUMMARY RNA editing is a post‐transcriptional pyrimidine exchange process that alters plastid and mitochondrial transcripts in nearly all land plants. Although confined to organelles, it is directed by nuclear‐encoded PLS‐type pentatricopeptide repeat (PPR) proteins, each typically recognizing a specific RNA target.
Blake D. Fauskee, Li‐Yaung Kuo, Farley Kwok van der Giezen, Kathleen M. Pryer   +3 more
wiley   +1 more source

A safe, effective and adaptable live-attenuated SARS-CoV-2 vaccine to reduce disease and transmission using one-to-stop genome modifications

Nature Microbiology
Approved vaccines are effective against severe COVID-19, but broader immunity is needed against new variants and transmission. Therefore, we developed genome-modified live-attenuated vaccines (LAV) by recoding the SARS-CoV-2 genome, including ‘one-to ...
Jacob Schön, G. Barut, B. Trüeb, N. Halwe, I. Berenguer Veiga, A. Kratzel, Lorenz Ulrich, Jenna N. Kelly, M. Brügger, C. Wylezich, Adriano Taddeo, Etori Aguiar Moreira, Demeter Túrós, Llorenç Grau-Roma, Ann Kathrin Ahrens, Kore Schlottau, T. Britzke, A. Breithaupt, Björn Corleis, Jana Kochmann, Blandina I. Oliveira Esteves, Lea Almeida, Lisa Thomann, C. Devisme, H. Stalder, Silvio Steiner, Sarah Ochsenbein, Kimberly Schmied, Fabien Labroussaa, Jörg Jores, P. V’kovski, Vladimir Cmiljanović, Marco P. Alves, C. Benarafa, N. Ebert, D. Hoffmann, Martin Beer, Volker Thiel   +37 more
semanticscholar   +1 more source