Results 51 to 60 of about 1,107,385 (165)
Assembly of Radically Recoded E. coli Genome Segments [PDF]
, 2016 Abstract The large potential of radically recoded organisms (RROs) in medicine and industry depends on improved technologies for efficient assembly and testing of recoded genomes for biosafety and functionality. Here we describe a next generation platform for conjugative assembly genome engineering, termed CAGE 2.0 ...
Norville, Julie E. +18 more
openaire +1 more source
Characterisation of DENV2 genome recoding.
, 2023 (a) Genomic maps showing regions of the DENV2-EGFP genome recoded with silent mutations. DENV2-EGFP is a dengue reporter virus that expresses EGFP. (b) Genomic maps of DENV2 FLuc translation reporter construct and subgenomic replicon.
Wei-Xin Chin (843752) +15 more
core +1 more source
RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging
Biological Reviews, EarlyView.ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad +5 more
wiley +1 more source
Attenuation of Viruses by Large-Scale Recoding of their Genomes: the Selection Is Always Biased [PDF]
Current Clinical Microbiology Reports, 2018 This review summarizes the current understanding of virus attenuation by large-scale recoding of viral genomes and discusses what would ultimately be necessary for construction of better and safer live modified virus vaccines.It has been shown that codon and codon pair deoptimization are rapid and robust methods that can be used for the development of ...
Osterrieder, Nikolaus, Kunec, Dusan
openaire +2 more sources
Synonymous genome recoding : a tool to explore microbial biology and new therapeutic strategies
, 2021 Synthetic genome recoding is a new means of generating designed organisms with altered phenotypes. Synonymous mutations introduced into the protein coding region tolerate modifications in DNA or mRNA without modifying the encoded proteins.
Franco Cirera, Sandra +4 more
core
Resolving tricky nodes in the tree of life through amino acid recoding [PDF]
, 2022 Genomic data allowed a detailed resolution of the Tree of Life, but "tricky nodes" such as the root of the animals remain unresolved. Genome-scale datasets are heterogeneous as genes and species are exposed to different pressures, and this can negatively
Giacomelli, M. +13 more
core +1 more source
Interdisciplinary Medicine, EarlyView.Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi +13 more
wiley +1 more source
Journal of Animal Breeding and Genetics, EarlyView.ABSTRACT The pressing requirement for agricultural systems to adopt climate change adaptation strategies specifically designed for tropical environments underscores the significance of implementing sustainable bull breeding practices in beef cattle operations.
Antonio Reverter +3 more
wiley +1 more source
Journal of Integrative Plant Biology, EarlyView.The rice aldehyde dehydrogenase OsALDH2B1 enhances grain size and tolerance to alkaline soil by repressing GRAIN SIZE 3 and activating catalases. SERL1‐mediated phosphorylation stabilizes OsALDH2B1 under stress, establishing a signaling axis that overcomes growth‐defense trade‐offs and provides a direct target for breeding high‐yield, alkaline ...
Zemin Ma +13 more
wiley +1 more source
Journal of Integrative Plant Biology, EarlyView.Pentatricopeptide repeat proteins coordinate nucleus‐organelle communication by modulating RNA metabolism within chloroplasts and mitochondria. This review highlights how they control critical processes like photosynthesis, seed development, fertility restoration, and stress survival in crops, and explores their potential as programmable tools for RNA ...
Mingming Wu +7 more
wiley +1 more source