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, 1988 The human genome contains 3 billion base pairs of DNA, sufficient to encode 100,000 to 300,000 genes. Since the number of genes that make up a human being is not known, this estimate is based upon a national average size for a mammalian gene. If the average gene is 30,000 bases long, there will be about 100,000 genes.
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2010
Whole genome sequencing provides the most comprehensive collection of an individual's genetic variation. With the falling costs of sequencing technology, we envision paradigm shift from microarray-based genotyping studies to whole genome sequencing. We review methodologies for whole genome sequencing.
Pauline C. Ng, Ewen F. Kirkness
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Whole genome sequencing provides the most comprehensive collection of an individual's genetic variation. With the falling costs of sequencing technology, we envision paradigm shift from microarray-based genotyping studies to whole genome sequencing. We review methodologies for whole genome sequencing.
Pauline C. Ng, Ewen F. Kirkness
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Whole-Exome/Genome Sequencing and Genomics
Pediatrics, 2013As medical genetics has progressed from a descriptive entity to one focused on the functional relationship between genes and clinical disorders, emphasis has been placed on genomics. Genomics, a subelement of genetics, is the study of the genome, the sum total of all the genes of an organism.
Barry H. Thompson +2 more
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Genome Sequencing and Annotation
2003The availability of complete microbial genome sequences enormously facilitates experimental molecular investigations of the respective organisms by providing complete lists of genes, their genetic contexts, and their predicted functions. This can be used in a number of ways to focus studies on bacterial pathogenesis and also vaccine development (1,2 ...
Alex C. Jeffries +2 more
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Nature Medicine, 1995
Full analysis of two microbial genomes points towards complete catalogues of virulence and disease genes while tracking the course of evolution.
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Full analysis of two microbial genomes points towards complete catalogues of virulence and disease genes while tracking the course of evolution.
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The GeneCards Suite: From Gene Data Mining to Disease Genome Sequence Analyses
Current Protocols in Bioinformatics, 2016Gil Stelzer +17 more
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Gene, 2012
The existence of fractal sets of DNA sequences have long been suspected on the basis of statistical analyses of genome data. In this article we identify for the first time explicitly the GA-sequences as a class of fractal genomic sequences that are easy to recognize and to extract, and are scattered densely throughout the chromosomes of a large number ...
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The existence of fractal sets of DNA sequences have long been suspected on the basis of statistical analyses of genome data. In this article we identify for the first time explicitly the GA-sequences as a class of fractal genomic sequences that are easy to recognize and to extract, and are scattered densely throughout the chromosomes of a large number ...
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Genome sequencing: Illuminating the sunflower genome
Nature Plants, 2017A high-quality sunflower genome provides insight into Asterid genome evolution. Moreover, integrative analyses based on quantitative genetics, expression and diversity data uncover the gene networks and candidate genes for oil metabolism and flowering time, two important agronomic traits for sunflowers.
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The complete genome sequence of Escherichia coli K-12.
Science, 1997F. Blattner +16 more
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