Results 51 to 60 of about 784,750 (273)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Chloroplast genome sequence of Solanum demissum, a wild tuber-bearing species was completed

open access: yesMitochondrial DNA. Part B. Resources, 2019
Solanum demissum is a wild tuber-bearing species belonging to Solanaceae family. The complete chloroplast genome of S. demissum was constituted by de novo assembly using a small amount of whole genome sequencing data.
Kwang-Soo Cho   +3 more
doaj   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

The complete chloroplast genome of Solanum berthaultii, one of the potato wild relative species

open access: yesMitochondrial DNA. Part B. Resources, 2017
Solanum berthaultii is a wild species belonging to Solanaceae family. The complete chloroplast genome of S. berthaultii was constituted by de novo assembly using a small amount of whole genome sequencing data. The chloroplast genome of S. berthaultii was
Tae-Ho Park
doaj   +1 more source

A Gapless, Unambiguous Genome Sequence of the Enterohemorrhagic Escherichia coli O157:H7 Strain EDL933. [PDF]

open access: yes, 2014
Escherichia coli EDL933 is the prototypic strain for enterohemorrhagic E. coli serotype O157:H7, associated with deadly food-borne outbreaks. Because the publicly available sequence of the EDL933 genome has gaps and >6,000 ambiguous base calls, we ...
Aziz, Ramy K   +4 more
core   +2 more sources

Social context prevents heat hormetic effects against mutagens during fish development

open access: yesFEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere   +5 more
wiley   +1 more source

Chloroplast genome sequence of the wild tetraploid potato relative Solanum stoloniferum

open access: yesMitochondrial DNA. Part B. Resources, 2018
Solanum stoloniferum is a wild tuber-bearing species belonging to Solanaceae family. The complete chloroplast genome of S. stoloniferum was constituted by de novo assembly using a small amount of whole genome sequencing data. The chloroplast genome of S.
Tae-Ho Park
doaj   +1 more source

A new and improved genome sequence of Cannabis sativa

open access: yesGigaByte, 2020
Cannabis is a diploid species (2n = 20), the estimated haploid genome sizes of the female and male plants using flow cytometry are 818 and 843 Mb respectively.
Shivraj Braich   +3 more
doaj   +1 more source

Evaluation of genome sequencing quality in selected plant species using expressed sequence tags. [PDF]

open access: yesPLoS ONE, 2013
BACKGROUND: With the completion of genome sequencing projects for more than 30 plant species, large volumes of genome sequences have been produced and stored in online databases.
Lingfei Shangguan   +7 more
doaj   +1 more source

Genome sequence of Christensenella minuta DSM 22607T [PDF]

open access: yes, 2017
Obesity influences and is influenced by the human gut microbiome. Here, we present the genome of Christensenella minuta, a highly heritable bacterial species which has been found to be strongly associated with obesity through an unknown biological ...
Hallsworth-Pepin, Kymberlie   +4 more
core   +2 more sources

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