Results 61 to 70 of about 1,157,209 (319)
Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients
Molecular Oncology, EarlyView.Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha +6 more
wiley +1 more source
Modern tools for annotation of small genomes of non-model eukaryotes [PDF]
arXiv, 2021 Nowadays, due to the increasing amount of experimental data obtained by sequencing, the most interest is focused on determining the functions and characteristics of its individual parts of the genome instead of determining the nucleotide sequence of the genome.
arxiv
A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini +11 more
wiley +1 more source
Gene duplication and paleopolyploidy in soybean and the implications for whole genome sequencing
BMC Genomics, 2007 Background Soybean, Glycine max (L.) Merr., is a well documented paleopolyploid. What remains relatively under characterized is the level of sequence identity in retained homeologous regions of the genome.
Nelson Rex T +11 more
doaj +1 more source
Correlation Between GC-content and Palindromes in Randomly Generated Sequences and Viral Genomes [PDF]
arXiv, 2013 GC-content, the ratio of guanine and cytosine bases in an entire nucleotide sequence, and palindromic sequences are unique for every organism due to genomic evolution. The goals of our research was to establish a correlation between GC-content and palindromic densities in wild-type viral and randomly-generated genomes.
arxiv
Screening Genome Sequences for Known RNA Genes and Motifs [PDF]
, 2015 This methods paper presents computational protocols for the identification of non-coding RNA genes or RNA motifs within genomic sequences. An application to bacterial small RNA is proposed.
arxiv +1 more source
Whole genome sequencing in pharmacogenomics [PDF]
Frontiers in Pharmacology, 2015 Pharmacogenomics aims to shed light on the role of genes and genomic variants in clinical treatment response. Although, several drug-gene relationships are characterized to date, many challenges still remain toward the application of pharmacogenomics in the clinic; clinical guidelines for pharmacogenomic testing are still in their infancy, whereas the ...
Theodora Katsila, George P. Patrinos
openaire +4 more sources
Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors
Molecular Oncology, EarlyView.Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi +6 more
wiley +1 more source
Whole genome sequence of a Turkish individual. [PDF]
PLoS ONE, 2014 Although whole human genome sequencing can be done with readily available technical and financial resources, the need for detailed analyses of genomes of certain populations still exists.
Haluk Dogan, Handan Can, Hasan H Otu
doaj +1 more source
The Genome Sequence DataBase (GSDB): meeting the challenge of genomic sequencing [PDF]
Nucleic Acids Research, 1996 The genome sequence database (GSDB) is a complete, publicly available relational database of DNA sequences and annotation maintained by the National Center for Genome Resources (NCGR) under a Cooperative Agreement with the US Department of Energy (DOE).
Jillian Burton +20 more
openaire +2 more sources