Results 81 to 90 of about 5,239,885 (381)

Linking the International Wheat Genome Sequencing Consortium bread wheat reference genome sequence to wheat genetic and phenomic data

Genome Biology, 2018
The Wheat@URGI portal has been developed to provide the international community of researchers and breeders with access to the bread wheat reference genome sequence produced by the International Wheat Genome Sequencing Consortium. Genome browsers, BLAST,
M. Alaux, J. Rogers, T. Letellier, Raphael Flores, Françoise Alfama, C. Pommier, N. Mohellibi, Sophie Durand, Erik Kimmel, Célia Michotey, Claire Guerche, M. Loaec, Mathilde Lainé, Delphine Steinbach, F. Choulet, Hélène Rimbert, P. Leroy, N. Guilhot, J. Salse, C. Feuillet, E. Paux, K. Eversole, A. Adam-Blondon, H. Quesneville   +23 more
semanticscholar   +1 more source

The Genome Sequence DataBase [PDF]

Nucleic Acids Research, 2000
The Genome Sequence DataBase (GSDB) is a database of publicly available nucleotide sequences and their associated biological and bibliographic information. Several notable changes have occurred in the past year: GSDB stopped accepting data submissions from researchers; ownership of data submitted to GSDB was transferred to GenBank; sequence analysis ...
M. P. Skupski, Carol Harger, Wen Huang, Andrew Farmer, Jeff T. Inman, Jennifer W. Weller, Faye D. Schilkey, Donald Kiphart, Guanghong Chen   +8 more
openaire   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Whole Genome Mapping with Feature Sets from High-Throughput Sequencing Data. [PDF]

PLoS ONE, 2016
A good physical map is essential to guide sequence assembly in de novo whole genome sequencing, especially when sequences are produced by high-throughput sequencing such as next-generation-sequencing (NGS) technology.
Yonglong Pan, Xiaoming Wang, Lin Liu, Hao Wang, Meizhong Luo   +4 more
doaj   +1 more source

The complete genome sequence of a Neandertal from the Altai Mountains

Nature, 2013
We present a high-quality genome sequence of a Neanderthal woman from Siberia. We show that her parents were related at the level of half-siblings and that mating among close relatives was common among her recent ancestors.
Kay Prüfer, F. Racimo, N. Patterson, F. Jay, S. Sankararaman, S. Sawyer, Anja Heinze, Gabriel Renaud, Peter H. Sudmant, C. D. Filippo, Heng Li, Swapan Mallick, M. Dannemann, Qiaomei Fu, Martin Kircher, Martin Kuhlwilm, M. Lachmann, M. Meyer, M. Ongyerth, Michael F. Siebauer, Christoph Theunert, Arti Tandon, Priya Moorjani, Joseph K. Pickrell, J. Mullikin, Samuel H. Vohr, R. Green, Ines Hellmann, Philip L. F. Johnson, H. Blanché, H. Cann, J. Kitzman, J. Shendure, E. Eichler, E. Lein, Trygve E Bakken, L. Golovanova, V. Doronichev, M. Shunkov, A. Derevianko, B. Viola, M. Slatkin, D. Reich, J. Kelso, S. Pääbo   +44 more
semanticscholar   +1 more source

Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution

FEBS Letters, EarlyView.
The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai, Richard J. McDowell, Robert J. Lucas   +2 more
wiley   +1 more source

ntEdit: scalable genome sequence polishing

bioRxiv, 2019
In the modern genomics era, genome sequence assemblies are routine practice. However, depending on the methodology, resulting drafts may contain considerable base errors.
R. Warren, Lauren Coombe, H. Mohamadi, Jessica Zhang, B. Jaquish, N. Isabel, Steven J. M. Jones, J. Bousquet, J. Bohlmann, I. Birol   +9 more
semanticscholar   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Genome-Tools: A Flexible Package for Genome Sequence Analysis

BioTechniques, 2002
Genome-tools is a Perl module, a set of programs, and a user interface that facilitates access to genome sequence information. The package is flexible, extensible, and designed to be accessible and useful to both nonprogrammers and programmers.
William Lee, Swaine L. Chen
doaj   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source