Results 21 to 30 of about 1,118,249 (314)

Application of massive parallel sequencing to whole genome SNP discovery in the porcine genome [PDF]

open access: yes, 2009
Background Although the Illumina 1 G Genome Analyzer generates billions of base pairs of sequence data, challenges arise in sequence selection due to the varying sequence quality.
Kerstens Hindrik HD   +24 more
core   +1 more source

Genomic sequencing in cancer [PDF]

open access: yesCancer Letters, 2013
Genomic sequencing has provided critical insights into the etiology of both simple and complex diseases. The enormous reductions in cost for whole genome sequencing have allowed this technology to gain increasing use. Whole genome analysis has impacted research of complex diseases including cancer by allowing the systematic analysis of entire genomes ...
Musaffe, Tuna, Christopher I, Amos
openaire   +2 more sources

Identifying predictive features of Clostridium difficile infection recurrence before, during, and after primary antibiotic treatment

open access: yesMicrobiome, 2017
Background Colonization by the pathogen Clostridium difficile often occurs in the background of a disrupted microbial community. Identifying specific organisms conferring resistance to invasion by C.
Sepideh Pakpour   +7 more
doaj   +1 more source

Routine use of microbial whole genome sequencing in diagnostic and public health microbiology [PDF]

open access: yes, 2012
This work is partly supported by funding from the Medical Research Council, the European Developing Country Clinical Trials Partnership, the Global Alliance for TB Drug Development, and the European Union.Whole genome sequencing (WGS) promises to be ...
Holden, MTG   +43 more
core   +1 more source

Four chromosome scale genomes and a pan-genome annotation to accelerate pecan tree breeding

open access: yesNature Communications, 2021
Pecan is an important specialty crop that has experienced extensive interspecific hybridization and nearly-obligate outcrossing. Here, the authors assemble diploid genomes of four outbred genotypes, identify interspecific introgressions through ...
John T. Lovell   +34 more
doaj   +1 more source

A Complete Mitochondrial Genome Sequence from a Mesolithic Wild Aurochs (Bos primigenius) [PDF]

open access: yes, 2010
Background The derivation of domestic cattle from the extinct wild aurochs (Bos primigenius) has been well-documented by archaeological and genetic studies.
Finlay Emma K.   +53 more
core   +1 more source

Of Mice and Genome Sequence [PDF]

open access: yesCell, 2001
Availability of the mouse genome sequence will have a major impact on the study of vertebrate evolution, mammalian biology, and animal models of human disease. Resources to explore genome biology in mice will maximize the effect of this watershed event.
Hamilton, B A, Frankel, W N
openaire   +2 more sources

Hidden biases in germline structural variant detection

open access: yesGenome Biology, 2021
Background Genomic structural variations (SV) are important determinants of genotypic and phenotypic changes in many organisms. However, the detection of SV from next-generation sequencing data remains challenging.
Michael M. Khayat   +10 more
doaj   +1 more source

The South Asian Genome [PDF]

open access: yes, 2014
The genetic sequence variation of people from the Indian subcontinent who comprise one-quarter of the world's population, is not well described. We carried out whole genome sequencing of 168 South Asians, along with whole-exome sequencing of 147 South ...
Li Yingrui   +200 more
core   +1 more source

Multi-Platform Next-Generation Sequencing of the Domestic Turkey (Meleagris gallopavo): Genome Assembly and Analysis [PDF]

open access: yes, 2010
A synergistic combination of two next-generation sequencing platforms with a detailed comparative BAC physical contig map provided a cost-effective assembly of the genome sequence of the domestic turkey (Meleagris gallopavo).
Kent M Reed   +405 more
core   +1 more source

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