Results 201 to 210 of about 4,923,579 (336)

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Linking lncRNA to genomic stability [PDF]

Science China Life Sciences, 2016
openaire   +2 more sources

The Role of Mitochondrial Genome Stability and Metabolic Plasticity in Thyroid Cancer. [PDF]

Biomedicines
Ren L, Liu W, Zheng J, Wu Q, Ai Z.
europepmc   +1 more source

Correction to: High-frequency somatic embryogenesis, nuclear DNA estimation of milkweed species (Asclepias latifolia, A. speciosa, and A. subverticillata), and genome size stability of regenerants [PDF]

, 2019
Hamidou F. Sakhanokho, Ebrahiem Babiker, Barbara J. Smith, Patricia R. Drackett   +3 more
openalex   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

A Histone-Fold Complex and FANCM Form a Conserved DNA-Remodeling Complex to Maintain Genome Stability [PDF]

, 2010
Zhijiang Yan, Mathieu Delannoy, Ling Chen, Danielle Daee, Fekret Osman, Parameswary A. Muniandy, Xi Shen, Anneke B. Oostra, Hansen Du, Jûrgen Steltenpool, Ti Lin, Beatrice Schuster, Chantal Décaillet, Andrzej Stasiak, Alicja Z. Stasiak, Stacie Stone, Maureen E. Hoatlin, Detlev Schindler, Christopher L. Woodcock, Hans Joenje, Ranjan Sen, Johan P. de Winter, Lei Li, Michael M. Seidman, Matthew C. Whitby, Kyungjae Myung, Angelos Constantinou, Weidong Wang   +27 more
openalex   +1 more source

Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis Care &Research, EarlyView.
Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla, Robert Lafyatis, Kevin F. Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J. Kass   +13 more
wiley   +1 more source

A SETD2-CDK1-lamin axis maintains nuclear morphology and genome stability. [PDF]

Nat Cell Biol
Khan A, Zhang C, Nguyen PG, Metts JM, Collins LC, Jain K, Mills CA, Vlach L, Li K, Brademeyer AL, Bowman BM, Major MB, Aubé J, Herring LE, Rathmell WK, Mason FM, Davis IJ, Zhang Q, Strahl BD.   +18 more
europepmc   +1 more source

Vertebrate WRNIP1 and BLM are required for efficient maintenance of genome stability

, 2008
Tomoko Hayashi, Masayuki Seki, Eri Inoue, Akari Yoshimura, Yumiko Kusa, Shusuke Tada, Takemi Enomoto   +6 more
openalex   +2 more sources

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source