Results 321 to 330 of about 4,923,579 (336)
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RAD51, genomic stability, and tumorigenesis
Cancer Letters, 2005Genomic instability is characteristic of malignant cells, and a strong correlation exists between abnormal karyotype and tumorigenicity. Increased expression of the homologous recombination and DNA repair protein Rad51 has been reported in immortalized cell lines and multiple primary tumor cell types which could alter recombination pathways to ...
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Systemic silencing: Mobile sRNA stabilizes genomes
Nature Plants, 2016Transcriptional gene silencing is a pivotal mechanism for regulating gene expression and genome stability. In Arabidopsis, combined analyses of small RNAs (sRNAs) and DNA methylation reveals that mobile 24-nt sRNAs are involved in reinforcing genome-wide silencing of transposons through DNA methylation.
Zhaoliang, Zhang +2 more
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Menopause: Genome stability as new paradigm
Maturitas, 2016Menopause is defined as the age-dependent permanent cessation of menstruation and ovulation due to ovarian failure. Menopause occurs on average around the age of 51 years. Recent genome-wide association studies (GWAS) have identified over 44 genetic variants that are associated with age of onset of natural menopause.
Joop S.E. Laven +4 more
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Iron and genome stability: An update
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2012Iron is an essential micronutrient which is required in a relatively narrow range for maintaining metabolic homeostasis and genome stability. Iron participates in oxygen transport and mitochondrial respiration as well as in antioxidant and nucleic acid metabolism.
Daniel, Prá +3 more
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2016
Ageing is defined as the progressive attrition of tissue/organ function resulting in an increased susceptibility to disease and death. The DNA mutation and damage theory of ageing posits that the accrual of genetic damage over time is the underlying cause of ageing.
Aditi U. Gurkar +2 more
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Ageing is defined as the progressive attrition of tissue/organ function resulting in an increased susceptibility to disease and death. The DNA mutation and damage theory of ageing posits that the accrual of genetic damage over time is the underlying cause of ageing.
Aditi U. Gurkar +2 more
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DNA precursor metabolism and genomic stability
The FASEB Journal, 2006ABSTRACT Intracellular concentrations of the four deoxyribonucleoside triphosphates (dNTPs) are closely regulated, and imbalances in the four dNTP pools have genotoxic consequences. Replication errors leading to mutations can occur, for example, if one dNTP in excess drives formation of a non‐Watson‐Crick base ...
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[BRCA1 and genomic stability].
Ai zheng = Aizheng = Chinese journal of cancer, 2003BRCA1 is a 220kDa nuclear protein with multiple functional domains. It interacts directly or indirectly with a variety of important proteins, including oncogene proteins (c-myc, E2F), tumor suppressor proteins (p53, RB, BRCA2), DNA damage repair proteins (RAD50, RAD51), cell-cycle regulators (cyclin, CDK), transcriptional regulators (RNA polymerase II)
Wen-Hong, Fan, Qi-Min, Zhan
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