A binary vector for transferring genomic libraries to plants [PDF]
, 1986 The transformation of mutant plants with a complete recombinant library derived from wild-type DNA followed by assay of transformed plants for complementation of the mutant phenotype is a promising method for the isolation of plant genes.
Simoens, Chris +8 more
core +1 more source
Alternative splicing and genomic stability [PDF]
Physical Biology, 2004 6 ...
openaire +3 more sources
BAF180 Promotes Cohesion and Prevents Genome Instability and Aneuploidy
Cell Reports, 2014 BAF180, a subunit of the PBAF chromatin remodeling complex, is frequently mutated in cancer. Although PBAF regulates transcription, it remains unclear whether this is what drives tumorigenesis in cells lacking BAF180.
Peter M. Brownlee +4 more
doaj +1 more source
Keratinocyte differentiation-dependent human papillomavirus gene regulation [PDF]
, 2017 Human papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive cancers. HPVs infect epithelial cells and their replication cycle is tightly linked with the differentiation process of the infected keratinocyte.
Graham, Sheila V.
core +1 more source
Arabidopsis RecQl4A suppresses homologous recombination and modulates DNA damage responses [PDF]
, 2005 The DNA damage response and DNA recombination are two interrelated mechanisms involved in maintaining the integrity of the genome, but in plants they are poorly understood.
Bachrati +64 more
core +3 more sources
GenEpi: gene-based epistasis discovery using machine learning. [PDF]
, 2020 BackgroundGenome-wide association studies (GWAS) provide a powerful means to identify associations between genetic variants and phenotypes. However, GWAS techniques for detecting epistasis, the interactions between genetic variants associated with ...
Alzheimer’s Disease Neuroimaging Initiative +9 more
core
The extent of error-prone replication-restart by homologous recombination is controlled by Exo1 and checkpoint proteins [PDF]
, 2014 Genetic instability, a hallmark of cancer, can occur when the replication machinery encounters a barrier. The intra-S phase checkpoint maintains stalled replication forks in a replication-competent configuration by phosphorylating replisome components ...
Ahn +80 more
core +2 more sources
Clinically Applicable Inhibitors Impacting Genome Stability [PDF]
Molecules, 2018 Advances in technology have facilitated the molecular profiling (genomic and transcriptomic) of tumours, and has led to improved stratification of patients and the individualisation of treatment regimes. To fully realize the potential of truly personalised treatment options, we need targeted therapies that precisely disrupt the compensatory pathways ...
Anu Prakash +3 more
openaire +2 more sources
Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C
Nature Communications, 2020 Mycobacteria Prim-PolC performs short gap synthesis following removal of lesions during excision repair. Here the authors resolve crystal structures of pre- and post-catalytic Prim-PolC complexes bound to gapped DNA substrates to define its mechanism.
Nigel C. Brissett +7 more
doaj +1 more source
Biomimetic hydroxyapatite nanocrystals are an active carrier for Salmonella bacteriophages [PDF]
, 2019 open access articlePurpose: The use of bacteriophages represents a valid alternative to conventional antimicrobial treatments, overcoming the widespread bacterial antibiotic resistance phenomenon.
Capparelli, Rosanna +12 more
core +2 more sources