Results 51 to 60 of about 437,562 (315)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido +3 morewiley +1 more sourceSpecialized interfaces of Smc5/6 control hinge stability and DNA association
Nature Communications, 2017 Structural Maintenance of Chromosomes (SMC) complexes maintain genome integrity by regulating the segregation of chromosomes. Here, Altet al. describe the structure of the heterodimeric Smc5/6-hinge from fission yeast and define functional features ...Aaron Alt, Hung Q. Dang, Owen S. Wells, Luis M. Polo, Matt A. Smith, Grant A. McGregor, Thomas Welte, Alan R. Lehmann, Laurence H. Pearl, Johanne M. Murray, Antony W. Oliver +10 moredoaj +1 more sourceInsights into the Musa genome: Syntenic relationships to rice and between Musa species [PDF]
, 2008 Background Musa species (Zingiberaceae, Zingiberales) including bananas and plantains are collectively the fourth most important crop in developing countries.Santos, Candice M.R., Sasaki Takuji, Magali Lescot, Matsumoto Takashi, D'Hont Angélique, Erin Hine, Pappas Junior, Georgios, Ciampi, A.Y., Pietro Piffanelli, D'Hont, Angélique, Althoff, Ryan, Manoel T Souza, Lescot Magali, Piffanelli, Pietro, Catherine M Ronning, Leebens-Mack Jim, Souza, M.T., Leebens-Mack, Jim, Ana Y Ciampi, Candice M.R Santos, Vilarinhos, Alberto, Ronning Catherine M, Manuel Ruiz, Vilarinhos Alberto D, Town Christopher D, Ciampi Ana Y, Ronning, Catherine, Santos, Candice Mr, Kanamori Hiroyuki, Ruiz, Manuel, Jim Leebens-Mack, Pappas Georgios J, Vilarinhos, Alberto Duarte, Arbogast, Tammy, Foo Cheung, Cheung, Foo, Ruiz Manuel, Lescot, Magali, Da Silva, Felipe, Town, Christopher, da Silva Felipe R, Matsumoto, Takashi, Haas, Brian, Miller, Robert Ng, Blanc Guillaume, Miller, Roberto Neil Gerard, Takashi Matsumoto, Souza, Manoel, Felipe R da Silva, Guillaume Blanc, Arbogast Tammy, Haas Brian J, Miller Robert NG, Takuji Sasaki, Chris D Town, Garsmeur, Olivier, Piffanelli Pietro, Hiroyuki Kanamori, Robert N. G. Miller, Alberto D Vilarinhos, Ciampi, Ana, Tammy Arbogast, Santos Candice MR, Santos, C.R., Althoff Ryan, Vilarinhos, A., Milller, R.N.G., Sasaki, Takuji, Garsmeur Olivier, Blanc, Guillaume, Angelique D'Hont, Pappas, Georgios, Glaszmann Jean-Christophe, Kanamori, Hiroyuki, Olivier Garsmeur, Souza Manoel T, Pappas, G., Ryan Althoff, Cheung Foo, Piffanelli, P., Dhont, A., Georgios J Pappas, Hine, Erin, Jean-Christophe Glaszmann, Glaszmann, Jean-Christophe, Silva, F.R., Brian J Haas, Hine Erin +87 morecore +1 more sourceDiversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.Ilaria Chiaradia, Madeline A. Lancasterwiley +1 more sourceCentromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex
Nature CommunicationsThe BTRR (BLM/TOP3A/RMI1/RMI2) complex resolves DNA replication and recombination intermediates to maintain genome stability. Alongside PICH, they target mitotic DNA intertwinements, known as ultrafine DNA bridges, facilitating chromosome segregation ...María Fernández-Casañas, Eleftheria Karanika, Umit Aliyaskarova, Tomisin Olukoga, Alex D. Herbert, Antony W. Oliver, Matthew Day, Adrijana Crncec, Kok-Lung Chan +8 moredoaj +1 more sourceMulti-Platform Next-Generation Sequencing of the Domestic Turkey (Meleagris gallopavo): Genome Assembly and Analysis [PDF]
, 2010 A synergistic combination of two next-generation sequencing platforms with a detailed comparative BAC physical contig map provided a cost-effective assembly of the genome sequence of the domestic turkey (Meleagris gallopavo).Kent M Reed, Zhang, Liqing, Zhang Hong-Bin, Kim, Heebal, Rami A Dalloul, Langenberger, D., Scheuring, C., Evans, Clive, Crooijmans, R. P. M. A., Lee, Mi-Kyung, Lee, Taeheon, Kim, H., Evans, C., Nefedov Mikhail, Mane, Shrinivasrao, Frederickson, K. M., Crooijmans, Richard P. M. A., Williams, K. P., Marz, M., Liqing Zhang, Paul Flicek, Dodgson, J. B., David Langenberger, Smith Jacqueline, Dodgson, J. B., Flicek, Paul, Dong, J. J., Jiang, A., Kim, K. W., Zhang Yang, Kim, H., Manja Marz, Long, J. A., Williams, Kelly P., Schatz Michael C., Julie A. Long, Raineri Emanuele, Folkerts, O., Otto Folkerts, Zhang, H.-B., McElroy, A. P., Zhang, L., Delany, Mary E., Long, Julie A., Kelly P. Williams, McElroy Audrey P., Paton, I. R., Beal Kathryn, de Jong, P., Vilella, A. J., Yorke, J. A., Vilella Albert J., Salzberg, Steven L., Harkins Tim T., Megens, H.-J., Kim Sungwon, Crasta Oswald, Burt, David W., Bouffard Pascal, Schroeder, S., Albert J. Vilella, Burt, D. W., Liliana Florea, Mane Shrinivasrao, Carl J. Schmidt, Modise, Thero, Harkins, T. T., Jacqueline Smith, Frederickson, Karin M., Kristal Cooper, Stadler Peter F., Martien A. M. Groenen, Steven L. Salzberg, van Tassell, C. P., Smith, E. J., Blomberg, L. A., Modise, T., Tafer, Hakim, Schmidt, C. J., William S Payne, Dong, Jennifer J., Florea Liliana, Vilella, A. J., Notredame, C., Lee, M. K., Smith, J., Kathryn Beal, Jiang, A., Bouffard, Pascal, Geo Pertea, Mi-Kyung Lee, Mane, S., Roberts, Richard J., Delany, M. E., Jerry B. Dodgson, Schmidt, Carl J., Pertea, Geo, Searle Stephen M. J., Williams, K. P., Frederickson Karin M., Beal, K., Tim T Harkins, Lee, T., Langenberger, David, Searle, S. M. J., Ruffier, M., Puiu, D., Dalloul, R. A., Van Tassell, C. P., Schatz, M. C., Julie A Long, Jennifer J Dong, Raineri, E., Modise Thero, Long Julie A., Reed, Kent M., De, Supriyo, Oswald Crasta, Zimin, Aleksey V., Folkerts, O., Zhang, Y., Schroeder Steven, Roger A Coulombe, Hoffmann Steve, Crasta, Oswald, McElroy, Audrey P., Tu, Zhijian Jake, Florea, L., Magali Ruffier, de, J. P., Curtis P. Van Tassell, Williams Kelly P., William S. Payne, Megens, H. J., Zhang, X., Bouffard, P., James A Yorke, Kaiser, Pete, Daniela Puiu, Stephen M. J. Searle, Modise, T., Notredame Cédric, Groenen, M. A. M., Hoffmann, Steve, Notredame, C��dric, Ruffier Magali, Taeheon Lee, Guillaume Marcais, Evans Clive, Le Ann Blomberg, Qioa, Dan, Herrero Javier, Zhang Liqing, Crooijmans, R. P., Kim, S., Evans, C., Prickett, Dennis, Groenen, M. A., Cooper, K., Tu, Z. J., Dalloul, R.A., De Supriyo, Kaiser, P., Schmidt, C. J., Van Tassell Curtis P., Tafer, H., Megens, Hendrik-Jan, Mane, Shrinivasrao P., Tafer, H., Marcais, G., Xiaojun Zhang, Crasta, O., Kyu-Won Kim, Dodgson Jerry B., Aleksey V. Zimin, Reed, K. M., Steve Hoffmann, Tu, Zhijian (Jake), Dalloul, Rami A., Ann Blomberg Le, Hoffmann, S., Zhang, Yang, David W Burt, Kent M. Reed, Pieter de Jong, Aslam, Luqman, Marz, M., Groenen, Martien A. M., Michael C Schatz, Zhijian Jake Tu, Burt David W., Pascal Bouffard, Pertea Geo, Richard P M A Crooijmans, Audrey P. McElroy, David W. Burt, Sonstegard, T. S., Marcais, G., Hakim Tafer, Smith, J., Zhang, H. B., Ruffier, Magali, Mikhail Nefedov, Albert J Vilella, Megens Hendrik-Jan, Clive Evans, Hendrik-Jan Megens, Kaiser Pete, Dennis Prickett, Puiu Daniela, Dan Qioa, Schroeder, S., Zhang, Hong-Bin, Zhang, Xiaojun, Audrey P McElroy, Zimin Aleksey V., Vilella, Albert J., Groenen, M. A. M., Martien A M Groenen, Coulombe, R. A., Supriyo De, Scheuring, C., Qioa, D., Van, T. C. P., Nefedov, M., Kim, K.-W., de Jong Pieter, McElroy, A. P., Folkerts, Otto, Yorke James A., Harkins, Tim T., Rami A. Dalloul, Zhijian (Jake) Tu, Lee Taeheon, Crooijmans, R.P.M.A., Searle, S. M., Megens, H. J., Edward J. Smith, Paton Ian R., Salzberg, S. L., Aleksey V Zimin, Cooper Kristal, Ian R. Paton, Emanuele Raineri, Langenberger David, Tu Zhijian (Jake), Long, J. A., Qioa, D., Coulombe, R. A., Pete Kaiser, Aslam Luqman, Mane, S., Delany, M. E., Schatz, M. C., Sonstegard Tad S., Marz, Manja, Payne, William S., Carl J Schmidt, Andrew Jiang, Tu, Z., James A. Yorke, Long, J.A., Kelly P Williams, Lee, T., Edward J Smith, Notredame, Cédric, Stadler, P. F., Aslam, L., Prickett Dennis, Zimin, A. V., Herrero, J., Searle, S. M. J., Burt, D. W., Luqman Aslam, Crasta, O., Langenberger, D., Kaiser, P., Stadler, P. F., Van Tassell, Curtis P., Schmidt Carl J., Sonstegard, Tad S., Marz Manja, Lee, M. K., Puiu, Daniela, Marcais Guillaume, Crooijmans Richard P. M. A., Blomberg, Le Ann, Groenen Martien A. M., de Jong, P., Ruffier, M., Tad S. Sonstegard, Dalloul, R. A., Jiang Andrew, Frederickson, K. M., Florea, Liliana, Aslam, M.L., Smith Edward J., de Jong, Pieter, Cédric Notredame, Kim, K. W., Searle, Stephen M. J., Smith, Jacqueline, Harkins, T. T., Smith, Edward J., Karin M Frederickson, Chantel Scheuring, Marcais, Guillaume, Dalloul Rami A., Curtis P Van Tassell, Kim, Kyu-Won, Kim, S., Mary E Delany, Hong-Bin Zhang, Michael C. Schatz, Scheuring, Chantel, Kim Kyu-Won, Jiang, Andrew, Payne, W. S., Folkerts Otto, Zhang, H. B., Zimin, A. V., Schroeder, Steven, Yorke, J. A., Megens, H.J.W.C., Heebal Kim, Payne, W. S., Ann Blomberg, Le, Beal, K., Smith, Jacqueline; id_orcid, Puiu, D., Reed, K. M., Crooijmans, R. P. M. A., Qioa Dan, Notredame, C., Pertea, G., Stephen M J Searle, Zhang Xiaojun, Prickett, D., Flicek, P., Salzberg, S. L., Karin M. Frederickson, Florea, L., Coulombe, Roger A., Smith, E. J., Delany Mary E., Scheuring Chantel, Sungwon Kim, Salzberg Steven L., Aslam, L., Jerry B Dodgson, Yang Zhang, Yorke, James A., Raineri, Emanuele, Paton, I. R., Bouffard, P., Tafer Hakim, Cooper, K., Dong, J. J., Nefedov, Mikhail, Kim Heebal, Cooper, Kristal, Roger A. Coulombe, Tim T. Harkins, Tad S Sonstegard, De, S., Nefedov, M., Herrero, Javier, Blomberg, L. A., Lee, M.-K., Mary E. Delany, Raineri, E., Zhang, L., Hoffmann, S., De, S., Peter F Stadler, Kim, Sungwon, Zhang, X., Thero Modise, Beal, Kathryn, Sonstegard, T. S., Richard P. M. A. Crooijmans, Prickett, D., Steven Schroeder, Payne William S., Jennifer J. Dong, Groenen, M., Ann Blomberg, L., Lee Mi-Kyung, Zhang, Y., Flicek, P., Zimin, A.V., Dong Jennifer J., Schatz, Michael C., Coulombe Roger A., Peter F. Stadler, Flicek Paul, Javier Herrero, Paton, Ian R., Herrero, J., Ian R Paton, Dodgson, Jerry B., Steven L Salzberg, Shrinivasrao Mane, Stadler, Peter F., Pertea, G., Reed Kent M. +405 morecore +1 more sourceHyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky +11 morewiley +1 more source
