Results 31 to 40 of about 437,562 (315)
Genomic stability and tumorigenesis
Seminars in Cancer Biology, 2005 Cancer research needs to explain the observed incidence of cancer. Many factors determine this process, including: the number of susceptible cells in the tissue of origin; the number of normal cell divisions through which susceptible cells pass in normal development and turnover; the number of cell divisions during tumorigenesis; the selective ...Sieber, O, Heinimann, K, Tomlinson, Iopenaire +2 more sourcesImmune Checkpoints in Viral Infections
Viruses, 2020 As evidence has mounted that virus-infected cells, such as cancer cells, negatively regulate the function of T-cells via immune checkpoints, it has become increasingly clear that viral infections similarly exploit immune checkpoints as an immune system ...Huiming Cai, Ge Liu, Jianfeng Zhong, Kai Zheng, Haitao Xiao, Chenyang Li, Xun Song, Ying Li, Chenshu Xu, Haiqiang Wu, Zhendan He, Qinchang Zhu +11 moredoaj +1 more sourceDefending the genome from the enemy within:mechanisms of retrotransposon suppression in the mouse germline [PDF]
, 2013 The viability of any species requires that the genome is kept stable as it is transmitted from generation to generation by the germ cells. One of the challenges to transgenerational genome stability is the potential mutagenic activity of transposable ...Richard R. Meehan, Dunican, Donncha S; id_orcid, Meehan, Richard, Ian R. Adams, Marie MacLennan, James H. Crichton, Crichton, James H, Maclennan, Marie, Adams, Ian R, Donncha S. Dunican +9 morecore +1 more sourceWhole-genome sequence-based analysis of thyroid function. [PDF]
, 2015 Normal thyroid function is essential for health, but its genetic architecture remains poorly understood. Here, for the heritable thyroid traits thyrotropin (TSH) and free thyroxine (FT4), we analyse whole-genome sequence data from the UK10K project (N=2 ...Paternoster, Lavinia, Williamson, Kathleen A., Silvia Naitza (186150), Parthiban Vijayarangakannan (16220357), Jouko Lönnqvist (250763), Peter N. Taylor, Crooks, Lucy, Ward, Kirsten, Down, T, UK0K Consortium, Brown, SJ, Sanna, Serena, Walsh, JP, Ewan Birney (7728), Birney, E, Ciampi, A, Dawn Muddyman (7596470), Flyod, James, Sanna, S, Bolton, P, So-Youn Shin (108976), Clement, Gail, Van Kogelenberg, Margriet, Evans, D, Morris, James, Benjamin H. Mullin, Maslen, John, Beales, P, Sadaf Faroogi (16220294), Foley, A. Reghan, Lu Chen (75170), Benjamin H Mullin (16220249), Edkins, Sarah, Flicek, Paul, Nicola Roberts (2465665), Bochukova, E, UK10K Consortium, Alexandros Onoufriadis (16220324), Richard Durbin (2217), Cirak, Sebhattin, Clapham, Peter, Tian Jing (5683679), Surdulescu, Gabriela L., Wang, Guangbiao, Andrew McIntosh (83234), Holmans, Peter Alan, Barroso, Inês, Chatterjee, Krishna, Kate Northstone (74777), Schoenmakers, Nadia, Jamie Bentham (126369), Panicker, V, Davey Smith, George, Kennedy, Karen, Bell, JT, Curtis, D, John P Beilby (16220255), John Maslen (57613), Perry, John R. B., Dunham, I, Christopher S Franklin (16220303), Danecek, Petr, Kogelenberg, Margriet Van, Metrustry, Sarah, MacArthur, Daniel, Jianping Sun (203689), David K Jackson (16220306), Timpson, Nicholas J, Mullin, BH, Stevens, Elizabeth, Antony, Dinu, Lavinia Paternoster (153181), David Curtis (82224), Jie Huang (104235), Memari, Y, Woltersdorf, W, Toniolo, D, Woltersdorf, Wolfram, Andrew D Johnson (7949558), Min, Josine, Lim, Ee M, Blackwood, Douglas, Bounds, R, Mangino Massimo (16220315), Julia Keogh (16220309), Klaudia Walter, Brown, Suzanne J., Mitchison, Hannah, Walsh, John P, Smith, GD, Aarno Palotie (41342), Day-Williams, Aaron, Karim Oualkacha (698776), Senduran Balasubramaniam (16220273), Holmans, Peter, Pingbo Zhang (467521), Serena Sanna (145737), Stephen Schiffels (16220336), Francesco Cucca (145742), Sebhattin Cirak (16220285), Cosgrove, Catherine, Tom Gaunt, Calissano, M, Bounds, Rebecca, Spector, Tim, Wilson, SG, Barrett, Jeffrey C., Flicek, P, Balasubramaniam, S, Consortium, U, Ian N M Day (16220291), Tachmazidou, Ionna, Shane McCarthy (67911), ?, ?, Hysi, Pirro, Shoumo Bhattacharya (126386), Campbell, Purdey J., Michela Traglia (123821), Sun, Jianping, Yang, Jian, Hart, Deborah, Min, J, Wilson, Scott G, Andrew D. Johnson, Daniela Toniolo, Matthias Geihs (4445731), Ciampi, Antonio, McQuillin, Andrew, McKechanie, Andrew G., Sally I Sharp (16220342), Ionna Tachmazidou (16220351), Taylor, Peter N, Dayan, Colin M., Steve E Humphries (13598860), Frank Dudbridge, Roberts, Nicola, Kathleen A Williamson (16220366), Yasin Memari, Rehnström, Karola, Cox, T, Chris Joyce (8053256), John P. Beilby, Du, Y, James Flyod (16220300), Cosgrove, C, Peter McGuffin (51507), Zheng, Hou Feng, Peter Scambler (192613), Matthew E Hurles (9130769), Jackson, David K., Yuanping Du (2577718), Eleftheria Zeggini, Marchini, Jonathan, Bentham, J, Cox, Tony, Guo, Xueqin, Guy Coates (16220288), George Davey Smith, Huang, J, Coates, G, Liren Huang (14079870), Chen, Lu, Traglia, Michela, Catherine Cosgrove (126371), Beate St Pourcian (16220348), Panicker, Vijay, Gabriela L. Surdulescu, Caroline Relton (3457379), Stephen O'Rahilly (2152), Francesco Muntoni (228210), Howie, Bryan, Turki, SA, Nicholas J. Timpson, Eleftheria Zeggini (21702), Memari, Yasin, Collier, David, Chatterjee, K, Silvia Naitza, Barnes, Michael R, Detelina Grozeva (4799844), Xu, Chang Jiang, Ana Valdes (169895), Walsh, John P., Ian Dunham (6370), O'Rahilly, Stephen, Vijay Panicker (271958), Liu, Ryan, Wain, Louise V., Naitza, S, Lek, Monkol, Sarah Metrustry (346411), Edkins, S, Walter, Klaudia, Serra, Eva, Danecek, P, Guangbiao Wang (3531449), Collier, D, Yu Wang (12152), Faroogi, Sadaf, Walters, James Tynan Rhys, Keogh, Julia, Carl Anderson (3469508), Antony, D, James Morris (202908), Robert K Semple (9104531), Taylor, Peter N., Shihab, Hashem A., Jennie Hui, Scambler, Peter, Daniel Geschwind (406536), Raymond, Lucy, Vincenzo Forgetta (756326), Karola Rehnström (177204), Artigas, Maria Soler, Ee M Lim (16220258), Schiffels, Stephen, Whyte, Tamieka, Oualkacha, Karim, Bhattacharya, Shoumo, Peter Clapham (14318958), O'Donovan, Michael Conlon, Fend Zhang (16220372), Brent Richards, J., Deborah Hart (567519), Crispian Wilson (16220369), Walters, James T.R., Allan Daly (16063727), Yuan, Wei, Northstone, Kate, Spasic-Boskovic, Olivera, Traglia, M, Yuan, W, Grundberg, E, Anderson, C, Michael J Owen (12557113), Curran, S, Jeffrey C Barrett (12832976), Wolfram Woltersdorf (16220264), Du, Yuanping, Taylor, PN, Antonio Ciampi (144369), Pimphen Charoen (252479), Wei Yuan (64653), Margarida Lopes (10108799), Chew, S, Kirsten Ward (3417971), Mattia Calissano (489523), Mullin, Benjamin H., Liang, Jieqin, Goncalo Abecasis (3159045), Chris Boustred (16220282), Gail Clement (211087), Graham R S Ritchie (16220333), Breen, Gerome, Shin, So Youn, Evans, David, Dayan, Colin M, Shelby Chew (16220240), Muntoni, Francesco, Andrew McQuillin (82209), Gaunt, Tom, Semple, Robert K., Saeed Al Turki (16220270), Zhang, Fend, Day-Williams, A, Ellis, P, Lee, Irene, Lim, Ee M., Turki, Saeed Al, Coates, Guy, Xu, ChangJiang, Lorraine Southam (802549), Thomas Keane (225299), Cirak, S, Campbell, Purdey J, Monkol Lek (287026), Eleonora Porcu, Surdulescu, GL, Hugh Gurling (237385), Hong Lin (46089), David Skuse (184848), Anderson, Carl, Klaudia Walter (5179), Louise V Wain (7795652), Celia Greenwood (650459), Tim Hubbard (26509), Daniel Lawson (5778), Curran, Sarah, Olli Pietilainen (5482613), Mathieson, Iain, Schmidts, Miriam, Lotchkova, Valentina, Shihab, Hashem A, Cucca, Francesco, Timpson, Nicholas J., David Collier (231300), Purdey J Campbell (16220243), Schlessinger, David, Vijayarangakannan, Parthiban, Lin, Hong, Chen, L, Richards, Brent, Sharp, Sally I., Hannah Mitchison (4520041), Lucy Crooks (3622238), Sarah Edkins (203067), Ayub, M, Shane Mccarthy, Vincent Plagnol (50600), Bobrow, Martin, Day, Ian N M, Dunham, Ian, Jim Stalker (84935), Visscher, Peter M., Moayyeri, Alireza, Jonathan Marchini (21497), Lydia Quaye (262803), Bhattacharya, S, John P Walsh (14569251), Purdey J. Campbell, Stalker, Jim, Richard Anney (394309), Peter Ellis (15708), Caroline Relton, Hou-Feng Zheng (152901), Brown, Suzanne J, Lucy Raymond (16220330), Elin Grundberg, Peter N Taylor (4001915), Hubbard, Tim, The Ukk Consortiumz, Johnson, Andrew D., Genevieve Lachance (13615720), Muhammad Ayub (582672), Johnson, Andrew D, Frank Dudbridge (102283), Tim Spector, Jamshidi, Yalda, Wheeler, Elanor, Maria Soler Artigas (5649805), Margriet Van Kogelenberg (16220354), Beilby, John P, Jun Wang (5906), Craddock, Nicholas John, Anney, Richard, Inês Barroso (2144), Gurling, Hugh, Lim, EM, Richards, J Brent, Douglas Blackwood (3464456), Skuse, David, O'Donnovan, Michael, Forgetta, V, Crooks, L, Paunio, Tiina, Clement, G, Suzanne J. Brown, Xiaosen Guo (7389236), David B Savage (12418102), Barnes, Michael R., Serena Sanna, Balasubramaniam, Senduran, Colin M Dayan (13752040), Greenwood, Celia, Joyce, Chris, Yasin Memari (108933), Martin Bobrow (316697), Ryan Liu (10197214), Naitza, Silvia, Iain Mathieson (113513), Beales, Phil, Alireza Moayyeri (2885609), Bobrow, M, Josine Min, Bentham, Jamie, Wilson, Scott G., Marenne, Gaëlle, Keren Carss (6062465), Francesco Cucca, Paul Flicek (77154), Hywel Williams (411033), Soranzo, N, Quaye, Lydia, Patrick Bolton (184868), Carss, Keren, Wang, Yu, Kemp, John, Craddock, N, Rebecca Bounds (6260324), Geschwind, Daniel, Petr Danecek, Relton, Caroline, Pourcian, Beate St, Zhang, Pingbo, Palotie, Aarno, Fatemifar, G, Zeggini, E, Tom Gaunt (448068), Valentina Lotchkova (16220312), Grundberg, Elin, Bryan Howie (218844), Owen, Michael J., John Kemp (7068905), Eleonora Porcu (186153), Charoen, Pimphen, Irene Lee (1882873), Zheng, Hou-Feng, Daly, Allan, Felicity Payne (262626), Yingrui Li (149030), Ritchie, Graham R.S., Anja Kolb-Kokocinski (15987), George Davey Smith (82619), Vincenzo Forgetta, Massimo, Mangino, Elin Grundberg (116416), Daniela Toniolo (74637), Zeggini, Eleftheria, Southam, Lorraine, Artigas, MS, Hou-feng Zheng, Spector, T, Chew, Shelby, Suzanne J Brown (16220246), Elizabeth Stevens (435621), Jordana T. Bell, James T R Walters (12040898), Celia Greenwood, Blackwood, D, Gaëlle Marenne (456680), Greenwood, C, Barnes, MR, Walter, K, Boustred, C, Jane Kaye (377943), Beilby, JP, Surdulescu, Gabriela L, Brent Richards (6033746), Shelby Chew, Nicholas J Timpson (11501651), Clair, David St, Griffin, Heather, Day, Ian N.M., Elena Bochukova (16220279), Pietilainen, Olli, Curtis, David, Victoria Parker (7055579), Birney, Ewan, Langford, Cordelia, Keane, Thomas, Davey Smith, G, ChangJiang Xu (144365), Williams, Hywel, Olivera Spasic-Boskovic (6881501), Perry, John R.B., Richards, J. Brent, Clapham, P, Johnson, AD, Small, Kerrin, Huang, Jie, Kerrin Small (174643), Wang, Jun, Michael O'Donnovan (16220321), Tamieka Whyte (16220363), Savage, David B., Forgetta, Vincenzo, Richard Durbin, Charoen, P, Daly, A, Kaye, Jane, David St Clair (16220345), Li, Rui, Hashem A Shihab (16220252), Ellis, Peter, Down, Thomas, Cordelia Langford (77345), David Schlessinger, Franklin, Christopher S., J Brent Richards (16220267), Timpson, NJ, Tony Cox (45594), Michael A Quai (16220327), Martin D Tobin (7795649), Ayub, Muhammad, Mullin, Benjamin H, Toniolo, Daniela, Walters, James T R, Plagnol, Vincent, Porcu, Eleonora, John P. Walsh, Hendricks, Audrey, Muddyman, Dawn, Jie Huang, Payne, Felicity, Susan Ring (119324), Phil Beales (16220276), Fatemifar, Ghazaleh, Shihab, HA, Owen, Michael John, Lawson, Daniel, Parr, Jeremy R., Elanor Wheeler (16220360), Campbell, PJ, Nicole Soranzo (12361), J. Brent Richards, Bolton, Patrick, Josine Min (3457367), Smith, George Davey, David Evans (41081), Kim Wong (262770), Dawn Muddyman, Futema, Marta, Lopes, Margarida, Porcu, E, Peter M Visscher (12557107), Nadia Schoenmakers (3929258), Wolfram Woltersdorf, Perry, JRB, Michael R Barnes (7949537), Grozeva, Detelina, Scott G Wilson (13533670), Geihs, Matthias, Onoufriadis, Alexandros, Soranzo, Nicole, Goncalo Abecasis, McCarthy, Shane, Muddyman, D, David Schlessinger (2399), Gabriela L Surdulescu (3810061), Lönnqvist, Jouko, Daniel MacArthur (3577367), Hashem A. Shihab, Quail, Michael A., Krishna Chatterjee (7753232), Jeremy R Parr (5622233), Andrew G McKechanie (16220318), McIntosh, Andrew, Jennie Hui (220409), Audrey Hendricks (6260327), Wei Yuan, Scott G. Wilson, Tim Spector (153290), Boustred, Chris, Parker, Victoria, Petr Danecek (570012), Jordana T Bell (16220261), Ghazaleh Fatemifar (206274), Huang, Liren, Gaunt, T, Jian Yang (12136), Jaana Suvisaari (364516), Nicole Soranzo, Shin, So-Youn, Guo, Xiaosen, Li, Yingrui, Xueqin Guo (783421), Cucca, F, Miriam Schmidts (166276), Yalda Jamshidi (262159), Dudbridge, F, Hui, Jennie, Nick Craddock (170215), Hui, J, Rui Li (4631), Gerome Breen (15025), Ring, Susan, Gallagher, Louise, Zheng, HF, Louise Gallagher (3879160), Barroso, I, Fitzpatrick, David R., Eva Serra (16220339), John R. B. Perry, Flyod, J, Aaron Day-Williams (174547), Breen, G, Calissano, Mattia, Marta Futema (12325427), Zheng, H-F, Anney, R, Pirro Hysi (247490), Dinu Antony (572707), Schlessinger, D, Jieqin Liang (3134550), Bell, Jordana T., Bochukova, Elena, McCarthy, S, Kalliope Panoutsopoulou (174570), Heather Griffin (295945), Thomas Down (174882), Wong, Kim, Perry, John RB, Perry, John R B, Ee M. Lim, David R Fitzpatrick (16220297), Abecasis, G, Suvisaari, Jaana, Fitzpatrick, DR, Hurles, Matthew E., Quai, Michael A., Ritchie, Graham R S, Lachance, Genevieve, Wilson, Crispian, Durbin, R, Brent Richards, J, Michela Traglia, Peter Holmans (28936), Abecasis, Goncalo, Vijay Panicker, Durbin, Richard, John R B Perry (3810094), Beilby, John P., Colin M. Dayan, Pimphen Charoen, Kolb-Kokocinski, Anja, Tiina Paunio (130281), Day, INM, Barrett, JC, Tobin, Martin D., Jing, Tian, Faroogi, S, Dudbridge, Frank, Valdes, Ana, Richards, JB, McGuffin, Peter, Karen Kennedy (2088841), Michael R. Barnes, Craddock, Nick, Panoutsopoulou, Kalliope, Relton, C, Sarah Curran (184863), Humphries, Steve E., Bell, Jordana T, Dayan, CM, A. Reghan Foley (10279212), Carss, K +635 morecore +1 more sourceSTUbLs in chromatin and genome stability [PDF]
Biopolymers, 2012 AbstractChromatin structure and function is based on the dynamic interactions between nucleosomes and chromatin‐associated proteins. In addition to the other post‐translational modifications considered in this review issue of Biopolymers, ubiquitin and SUMO proteins also have prominent roles in chromatin function.Renee, Garza, Lorraine, Pillusopenaire +2 more sourcesGenome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned [PDF]
, 2010 Major depressive disorder (MDD) is a common complex disorder with a partly genetic etiology. We conducted a genome-wide association study of the MDD2000+ sample (2431 cases, 3673 screened controls and >1 M imputed single-nucleotide polymorphisms (SNPs)). D I Boomsma, Maclean, A. W., Sullivan, P.F., Sullivan, P F, G Willemsen, de Geus, E.J.C., D J Statham, Willemsen, G.; id_orcid, Gordon, SD, Penninx, BWJH, Smit, J H, Medland, S E, Maclean, A.W., S E Medland, Penninx, B. W. J. H., van den Oord, E J C G, Montgomery, G W, Pergadia, M L, Byrne, E.M., Heath, A.C., Martin, N.G., MacIntyre, Donald; id_orcid, Hickie, I.B., Statham, D.J., C M Middeldorp, E M Byrne, B W J H Penninx, Nyholt, D.R., J J Hottenga, J H Smit, A K Henders, Blackwood, D.H., Liu, J. Z., N G Martin, A W Maclean, Lewis, C.M., Montgomery, G. W., McGuffin, P, S D Gordon, McEvoy, B.P., MacIntyre, D J, McGhee, K A, P A F Madden, MacIntyre, D J; id_orcid, Pergadia, M. L., van den Oord, E.J., McEvoy, B P, Gordon, S.D., Martin, N. G., D H R Blackwood, P F Sullivan, De Geus, E. J. C., Montgomery, G.W., Hottenga, J.J., Hickie, I. B., McGhee, K.A., Medland, S. E., C M Lewis, J Z Liu, Gordon, S D, Smit, J. H., Boomsma, D. I., Hottenga, J. J., Smit, J.H., Middeldorp, C.M., Ripke, S., M L Pergadia, Hickie, I B, de Geus, E.J., Wray, NR, Van Den Oord, E. J. C. G., Wray, N. R., Blackwood, DHR, de Geus, E J C, Penninx, B.W., B P McEvoy, McGhee, K. A., Middeldorp, C. M., Byrne, E. M., McEvoy, B. P., Macgregor, S, E J C G van den Oord, Statham, D J, Heath, A C, Lewis, C. M., van den Oord, E.J.C.G., I B Hickie, Willemsen, G., Pergadia, M.L., Medland, S.E., Sullivan, P. F., Penninx, B.W.J.H., Heath, A. C., Maclean, AW, Nyholt, D. R., N R Wray, S Macgregor, MacIntyre, DJ, Boomsma, D.I., G W Montgomery, Lewis, C M, Henders, A K, Madden, P. A. F., Madden, P.A.F., Henders, A.K., Hottenga, J J, McGuffin, P., Boomsma, D I, Madden, P.A., de Geus, E.J.C.; id_orcid, Oord, E.J.C.G. van den, Henders, A. K., Wray, N R, Madden, P A F, E J C de Geus, Pergadia, ML, D R Nyholt, Maclean, A W, Ripke, S, A C Heath, Ripke, Stephan, MacIntyre, D. J., Geus, E.J.C. de, Blackwood, D. H. R., Statham, D. J., Penninx, B W J H, Macgregor, S., Gordon, S. D., McGhee, KA, D J MacIntyre, Nyholt, D R, Wray, N.R., Middeldorp, C M, Liu, J Z, S Ripke, K A McGhee, P McGuffin, Nyholt, DR, Willemsen, G, Boomsma, D.I.; id_orcid, Lewis, C. M.; id_orcid, Martin, N G, Blackwood, D H R, Liu, J.Z., Byrne, E M, MacIntyre, D.J. +145 morecore +1 more source
