Results 11 to 20 of about 437,562 (315)
HSP70 and Genomic Stability [PDF]
Cell Cycle, 2004 The 70 kDa heat shock proteins (HSP70s) were initially identified by their elevated expression following hyperthermic cell stress, however, these highly conserved proteins also protect critical cellular functions from a wider range of important environmental and physiological stresses.
Tej K, Pandita +2 more
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Chromium and genomic stability [PDF]
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2012 Many metals serve as micronutrients which protect against genomic instability. Chromium is most abundant in its trivalent and hexavalent forms. Trivalent chromium has historically been considered an essential element, though recent data indicate that while it can have pharmacological effects and value, it is not essential.
Sandra S, Wise, John Pierce, Wise
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Echoed induction of nucleotide variants and chromosomal structural variants in cancer cells
Scientific Reports, 2022 Generally, the number of single-nucleotide variants (SNVs) in somatic cells increases with age, which is expected for replication errors. The number of SNVs in cancer cells, however, is often much higher than that in somatic cells, raising the question ...
Yusuke Matsuno +4 more
doaj +1 more source
eLife, 2023 Arrested replication forks, when restarted by homologous recombination, result in error-prone DNA syntheses and non-allelic homologous recombination. Fission yeast RTS1 is a model fork barrier used to probe mechanisms of recombination-dependent restart ...
Alice M Budden +6 more
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CRISPR-Associated Primase-Polymerases are implicated in prokaryotic CRISPR-Cas adaptation
Nature Communications, 2021 CAPPs are putative Primase-Polymerases associated with CRISPR-Cas operons. Here, the authors show CAPPs genetic and physical association with Cas1 and Cas2, their capacity to function as DNA-dependent DNA primases and DNA polymerases, and that Cas1-Cas2 ...
Katerina Zabrady +4 more
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Replication dynamics of recombination-dependent replication forks
Nature Communications, 2021 Replication forks that are stalled at obstacles on the DNA template can be restarted by homologous recombination. Here, the authors show replication dynamics during homologous recombination-dependent replication fork restart by combining polymerase usage
Karel Naiman +5 more
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eLife, 2021 The essential Smc5/6 complex is required in response to replication stress and is best known for ensuring the fidelity of homologous recombination. Using single-molecule tracking in live fission yeast to investigate Smc5/6 chromatin association, we show ...
Thomas J Etheridge +10 more
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Hypoxia stabilizes SETDB1 to maintain genome stability
Nucleic Acids Research, 2023 Abstract Von Hippel–Lindau (VHL) is a tumor suppressor that functions as the substrate recognition subunit of the CRL2VHL E3 complex. While substrates of VHL have been identified, its tumor suppressive role remains to be fully understood.
Sungryul Park +14 more
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Inhibition of MRN activity by a telomere protein motif
Nature Communications, 2021 Telomeres suppress the DNA damage response at chromosome ends. Here the authors show that in budding yeast the activity of the MRX complex in DNA repair and DNA damage signaling is inhibited by telomeric protein Rif2 via a short motif at the N-terminus.
Freddy Khayat +11 more
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Diploid-specific genome stability genes of S. cerevisiae: genomic screen reveals haploidization as an escape from persisting DNA rearrangement stress. [PDF]
, 2011 Maintaining a stable genome is one of the most important tasks of every living cell and the mechanisms ensuring it are similar in all of them. The events leading to changes in DNA sequence (mutations) in diploid cells occur one to two orders of magnitude
Skoneczna, Adrianna +8 more
core +1 more source