Results 21 to 30 of about 3,499,703 (265)

The Capsaspora genome reveals a complex unicellular prehistory of animals [PDF]

, 2013
To reconstruct the evolutionary origin of multicellular animals from their unicellular ancestors, the genome sequences of diverse unicellular relatives are essential. However, only the genome of the choanoflagellate Monosiga brevicollis has been reported
Chen, Zehua, Kerner, Pierre, Ruiz-Trillo, Iñaki, Vervoort, Michel, Sánchez-Pons, Núria, Russ, Carsten, Kramer, Eric, Carr, Martin, Roger, Andrew J., Suga, Hiroshi, Nusbaum, Chad, de Mendoza, Alex, Haas, Brian J., Lang, B. Franz, Manning, Gerard, Sebé-Pedrós, Arnau, Torruella, Guifré, Derelle, Romain, Brown, Matthew W., Mendoza, Alex de   +19 more
core   +1 more source

Where and when to start: Regulating DNA replication origin activity in eukaryotic genomes

Nucleus, 2023
In eukaryotic genomes, hundreds to thousands of potential start sites of DNA replication named origins are dispersed across each of the linear chromosomes.
Clare S.K. Lee, Matthias Weiβ, Stephan Hamperl   +2 more
doaj   +1 more source

Transcriptome and methylome profiling reveals relics of genome dominance in the mesopolyploid Brassica oleracea [PDF]

, 2014
Background: Brassica oleracea is a valuable vegetable species that has contributed to human health and nutrition for hundreds of years and comprises multiple distinct cultivar groups with diverse morphological and phytochemical attributes.
John Nixon, Denoeud, France, Parkin, Isobel AP, Annaliese S Mason, Town, Chris D, Huebert, Terry, Sharpe, Andrew G., Manoli, Sahana, Bancroft, Ian, France Denoeud, Sateesh Kagale, Just, J\ue9r\ue9my, Robinson, Stephen J., Vivek Krishnakumar, Clarke, Carling, Links, Matthew G., Robinson, Stephen J, Wayne E Clarke, Guy Barker, Barker, Guy C., Shelby L Bidwell, Koh, Chushin, Moore, Jonathan D., Sharpe, Andrew G, Jacqueline Batley, Edwards, David, Clarke, Wayne E., Harry Belcram, Jérémy Just, Bidwell, Shelby L., Just, Jérémy, Carling Clarke, Jonathan Moore, Edwards, Dave, Nelson, Matthew N, David Edwards, Batley, Jacqueline, Matthew N Nelson, Stephen J Robinson, Sahana Manoli, Bidwell, Shelby L, Pires, J. Chris, Parkin, Isobel A. P., Chalhoub, Boulos, Terry Huebert, Andrew H Paterson, Krishnakumar, Vivek, Belcram, Harry, H., Walley, Peter G, Bender, Tricia, Tricia Bender, Town, Chris D., Nelson, Matthew N., King, Graham, J Pires, Mason, Annaliese S., Graham King, Pires, Chris J., Matthew G Links, Nixon, John, Chris D Town, Boulos Chalhoub, Links, Matthew G, Ian Bancroft, Belcram, Harry, Walley, Peter G., Mason, Annaliese S, Paterson, Andrew H, Walley, Peter Glen, Paterson, Andrew H., Moore, Jonathan, Barker, Guy, Kagale, Sateesh, Wang, Xiyin, Tang, Haibao, Pires, J Chris, Isobel AP Parkin, Pires, J., Andrew G Sharpe, Clarke, Wayne E, Xiyin Wang, Haibao Tang, Peter G Walley, Chushin Koh   +83 more
core   +1 more source

BAF180 Promotes Cohesion and Prevents Genome Instability and Aneuploidy

Cell Reports, 2014
BAF180, a subunit of the PBAF chromatin remodeling complex, is frequently mutated in cancer. Although PBAF regulates transcription, it remains unclear whether this is what drives tumorigenesis in cells lacking BAF180.
Peter M. Brownlee, Anna L. Chambers, Ross Cloney, Alessandro Bianchi, Jessica A. Downs   +4 more
doaj   +1 more source

Somatic PMK-1/p38 signaling links environmental stress to germ cell apoptosis and heritable euploidy

Nature Communications, 2022
Here the authors show that elimination of germ cells carrying damaged genomes is regulated by intestinal stress signalling in nematodes. Failure of the intestinal signalling results in stress-induced aneuploidy indicating that environmental stress ...
Najmeh Soltanmohammadi, Siyao Wang, Björn Schumacher   +2 more
doaj   +1 more source

Specialized interfaces of Smc5/6 control hinge stability and DNA association

Nature Communications, 2017
Structural Maintenance of Chromosomes (SMC) complexes maintain genome integrity by regulating the segregation of chromosomes. Here, Altet al. describe the structure of the heterodimeric Smc5/6-hinge from fission yeast and define functional features ...
Aaron Alt, Hung Q. Dang, Owen S. Wells, Luis M. Polo, Matt A. Smith, Grant A. McGregor, Thomas Welte, Alan R. Lehmann, Laurence H. Pearl, Johanne M. Murray, Antony W. Oliver   +10 more
doaj   +1 more source

Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C

Nature Communications, 2020
Mycobacteria Prim-PolC performs short gap synthesis following removal of lesions during excision repair. Here the authors resolve crystal structures of pre- and post-catalytic Prim-PolC complexes bound to gapped DNA substrates to define its mechanism.
Nigel C. Brissett, Katerina Zabrady, Przemysław Płociński, Julie Bianchi, Małgorzata Korycka-Machała, Anna Brzostek, Jarosław Dziadek, Aidan J. Doherty   +7 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex

Nature Communications
The BTRR (BLM/TOP3A/RMI1/RMI2) complex resolves DNA replication and recombination intermediates to maintain genome stability. Alongside PICH, they target mitotic DNA intertwinements, known as ultrafine DNA bridges, facilitating chromosome segregation ...
María Fernández-Casañas, Eleftheria Karanika, Umit Aliyaskarova, Tomisin Olukoga, Alex D. Herbert, Antony W. Oliver, Matthew Day, Adrijana Crncec, Kok-Lung Chan   +8 more
doaj   +1 more source