Results 21 to 30 of about 437,562 (315)
Draft genome sequence of the Daphnia pathogen Octosporea bayeri: insights into the gene content of a large microsporidian genome and a model for host-parasite interactions [PDF]
, 2009 Background: The highly compacted 2.9-Mb genome of Encephalitozoon cuniculi placed the microsporidia in the spotlight, encoding a mere 2,000 proteins and a highly reduced suite of biochemical pathways.
Ebert, Dieter +10 more
core +1 more source
Royal Society Open Science, 2021 Unlike bacteria, mammalian cells need to complete DNA replication before segregating their chromosomes for the maintenance of genome integrity. Thus, cells have evolved efficient pathways to restore stalled and/or collapsed replication forks during S ...
Camelia Mocanu, Kok-Lung Chan
doaj +1 more source
Genes and Environment, 2021 Background Stress response is mediated by the transcription of stress-responsive genes. The F-box motif protein Saf1p is involved in SCF-E3 ligase mediated degradation of the adenine deaminase, Aah1p upon nutrient stress.
Meenu Sharma +2 more
doaj +1 more source
SIRT7: a sentinel of genome stability [PDF]
Open Biology, 2021 SIRT7 is a class III histone deacetylase that belongs to the sirtuin family. The past two decades have seen numerous breakthroughs in terms of understanding SIRT7 biological function. We now know that this enzyme is involved in diverse cellular processes, ranging from gene regulation to genome stability, ageing and tumorigenesis. Genomic instability is
Ming Tang +3 more
openaire +3 more sources
Ku and the Stability of the Genome [PDF]
BioMed Research International, 2002 Ku proteins are associated with a variety of cellular processes such as repair of DNA‐double‐strand breaks, telomere maintenance and retrotransposition. In recent years, we have learned a lot about their cellular and molecular functions and it has turned out that Ku‐dependent processes affect the stability of the genome, both positively and negatively,
openaire +2 more sources
A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome
Nature Communications, 2019 Topoisomerase 2 (Top2) is known to resolve DNA topological stress through double strand breaks (DSBs), yet Top2 inhibition has been reported to result in a significant amount of single-strand breaks (SSBs).
William H. Gittens +5 more
doaj +1 more source
Nature Communications, 2019 The kinase PLK1 has important roles during cell division, including mitotic entry and bipolar spindle formation. Here, the authors show that PLK1 also functions in centromere protection, with loss leading to DNA unwinding by Bloom’s syndrome helicase and
Owen Addis Jones +4 more
doaj +1 more source
Maintenance of Genome Stability
Genomics, Proteomics & Bioinformatics, 2016 It was ever thought that genomic information is transmitted faithfully from generation to generation. But our current knowledge does not indicate that it is the case. For example, genomic variations can be generated from DNA replication infidelity and unequal chromosome segregation.
Jiadong Wang, Tomas Lindahl
openaire +4 more sources
Nature Communications, 2018 Chromosome instability is associated with cancer formation. Here the authors identify in cultured human cancer cells a non-canonical DNA bridge breakage pathway leading to chromosome missegregation and rearrangements triggered by sister DNA ...
Ankana Tiwari +2 more
doaj +1 more source
Nature Communications, 2016 Werner syndrome is a progeroid disease characterised by genetic instability due to mutations to the WRN helicase/exonuclease. Here the authors define a novel Ku binding motif (KBM) and show that two such motifs facilitate the involvement of WRN in DNA ...
Gabrielle J. Grundy +7 more
doaj +1 more source