Results 41 to 50 of about 437,562 (315)

Where and when to start: Regulating DNA replication origin activity in eukaryotic genomes

open access: yesNucleus, 2023
In eukaryotic genomes, hundreds to thousands of potential start sites of DNA replication named origins are dispersed across each of the linear chromosomes.
Clare S.K. Lee   +2 more
doaj   +1 more source

The First Myriapod Genome Sequence Reveals Conservative Arthropod Gene Content and Genome Organisation in the Centipede Strigamia maritima [PDF]

open access: yes, 2014
Myriapods (e.g., centipedes and millipedes) display a simple homonomous body plan relative to other arthropods. All members of the class are terrestrial, but they attained terrestriality independently of insects. Myriapoda is the only arthropod class not
Capella-Gutiérrez Salvador   +999 more
core   +1 more source

Repetitive DNA is associated with centromeric domains in Trypanosoma brucei but not Trypanosoma cruzi. [PDF]

open access: yes, 2007
BACKGROUND: Trypanosomes are parasitic protozoa that diverged early from the main eukaryotic lineage. Their genomes display several unusual characteristics and, despite completion of the trypanosome genome projects, the location of centromeric DNA has ...
Bot, Christopher   +9 more
core   +1 more source

BAF180 Promotes Cohesion and Prevents Genome Instability and Aneuploidy

open access: yesCell Reports, 2014
BAF180, a subunit of the PBAF chromatin remodeling complex, is frequently mutated in cancer. Although PBAF regulates transcription, it remains unclear whether this is what drives tumorigenesis in cells lacking BAF180.
Peter M. Brownlee   +4 more
doaj   +1 more source

Caloric restriction and genomic stability [PDF]

open access: yesNucleic Acids Research, 2007
Caloric restriction (CR) reduces the incidence and progression of spontaneous and induced tumors in laboratory rodents while increasing mean and maximum life spans. It has been suggested that CR extends longevity and reduces age-related pathologies by reducing the levels of DNA damage and mutations that accumulate with age.
Heydari, Ahmad R.   +3 more
openaire   +2 more sources

ARID1A mutation and genomic stability [PDF]

open access: yesMolecular & Cellular Oncology, 2020
We have recently discovered that AT-rich interactive domain-containing protein 1A (ARID1A) protects telomere cohesion through regulation of the cohesin subunit stromal antigen 1 (STAG1). ARID1A inactivation results in mitotic defects and negatively selects gross chromosomal aberrations, resulting in preservation of genomic stability in ARID1A-mutated ...
Timothy Nacarelli   +3 more
openaire   +3 more sources

Genome Stability Requires p53 [PDF]

open access: yesCold Spring Harbor Perspectives in Medicine, 2016
It is now clear that functional p53 is critical to protect the genome from alterations that lead to tumorigenesis. However, with the myriad of cellular stresses and pathways linked to p53 activation, much remains unknown about how p53 maintains genome stability and the proteins involved. The current understanding of the multiple ways p53 contributes to
openaire   +2 more sources

Genomic stability of Self-inactivating Rabies [PDF]

open access: yeseLife, 2020
Abstract Transsynaptic viral vectors provide means to gain genetic access to neurons based on synaptic connectivity and are essential tools for the dissection of neural circuit function. Among them, the retrograde monosynaptic ΔG-Rabies has been widely used in neuroscience research.
Ernesto Ciabatti   +5 more
openaire   +3 more sources

Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C

open access: yesNature Communications, 2020
Mycobacteria Prim-PolC performs short gap synthesis following removal of lesions during excision repair. Here the authors resolve crystal structures of pre- and post-catalytic Prim-PolC complexes bound to gapped DNA substrates to define its mechanism.
Nigel C. Brissett   +7 more
doaj   +1 more source

The Stability and Evolution of Genes and Genomes

open access: yesGenes, 2023
The existence of current species can be attributed to a dynamic interplay between evolutionary forces and the maintenance of genetic information [...]
Luigi Viggiano   +1 more
openaire   +3 more sources

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